María Julieta Russo

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

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Ricardo Allegri

Instituto de Neurología Cognitiva

Gustavo Sevlever

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Jorge Campos

Ludwig-Maximilians-Universität München

Gabriela Cohen

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Ezequiel Surace

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Silvia Vázquez

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Gennaro D’Amato

Fatebenefratelli Hospital

Maria D’Amato

Ospedale Monaldi

Patricio Chrem Méndez

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Gennaro Liccardi

University of Rome Tor Vergata

Cooperative Institutions

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Instituto de Neurología Cognitiva

RELX Group (Netherlands)

RELX Group (United States)

University of Naples Federico II

University of Campania "Luigi Vanvitelli"

Istituti di Ricovero e Cura a Carattere Scientifico

Fatebenefratelli Hospital

University of Buenos Aires

Consejo Nacional de Investigaciones Científicas y Técnicas

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Driving and Alzheimer's disease: A neuropsychological screening battery for the elderly

Figshare (2019)

Lucía Crivelli María Julieta Russo Mauricio Farez Mariana Bonetto Cecilia Prado

ABSTRACT As life expectancy increases, there is a marked increase in the elderly population eager to continue driving. A large proportion of these elderly drive safely, however, patients with mild dementia are high-risk drivers. Objective: to identify the cognitive tests that best predict driving ability in subjects with mild dementia. Methods: 28 drivers with mild dementia and 28 healthy elderly subjects underwent an extensive cognitive assessment (NACC Uniform Data Set Neuropsychological Battery), completed an adapted On Road Driving Test (ORDT) and a Driving Simulator assessment. Results: drivers with mild dementia made more mistakes on the ORDT and had slower responses in the simulator tasks. Cognitive tests correlated strongly with on road and simulator driving performance. Age, the Digit Symbol Modalities Test and Boston Naming Test scores were the variables that best predicted performance on the ORDT and were included in a logistic regression model. Conclusion: the strong correlation between driving performance and performance on specific cognitive tests supports the importance of cognitive assessment as a useful tool for deciding whether patients with mild dementia can drive safely. The algorithm including these three variables could be used as a screening tool for the detection of unsafe driving in elderly subjects with cognitive decline.

10.6084/m9.figshare.9900005

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Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy

Allergy (1997)

Gennaro D’Amato Giorgos Chatzigeorgiou R Córsico D. Gioulekas Lothar Jäger

D'Amato G, Chatzigeorgiou G, Corsico R, Gioulekas D, Jäger L, Jäger S, Kontou‐Fili K, Kouridakis S, Liccardi G, Meriggi A, Palma‐Carlos A, Palma‐Carlos ML, Pagan Aleman A, Parmiani S, Puccinelli R Russo M, Spieksma FThM, Torricelli R, Wüthrich B. Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy. A European multicenter study promoted by the Subcommittee on Aerobiology and Environmental Aspects of Inhalant Allergens of the European Academy of Allergology and Clinical Immunology. This trial was undertaken to study, in several geographically spread European countries, the prevalence of skin prick test (SPT) positivity to Alternaria (A) and Cladosporium (C) in subjects with nasal and/or bronchial symptoms of suspected allergic cause. Each patient completed an anamnestic questionnaire and underwent SPT with a panel of common inhalant allergens and also A and C supplied by three different laboratories, to allow for manufacturer bias. Specific scrum IgE determination was carried out only in subjects with SPT positivity to A and/or C with an immunoassay system. In nine European allergology centers, a total of 877 subjects was enrolled in the trial; 83 of them showed SPT positivity to A and/or C; only nine patients showed monosensitization to A , and none to C The highest percentage of positive subjects was found in Spain (20%); the lowest in Portugal (3%). In the other seven centers, the variation was 7–10%. The age range of mold‐positive subjects was 5–60 years. Rhinitis was by far the most common symptom, whether associated or not with asthma and/or conjunctivitis.

Respiratory allergy

Cladosporium

Aeroallergen

10.1111/j.1398-9995.1997.tb01227.x

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Citations (139)

Diagnostic accuracy of biomarker combinations in the A/T/N classification for Alzheimer’s disease (P4.182)

Neurology (2018)

Patricio Chrem Méndez Ismael Luis Calandri Ignacio Demey Lucía Pertierra María Julieta Russo

April 25, 2018April 10, 2018Free AccessDiagnostic accuracy of biomarker combinations in the A/T/N classification for Alzheimer’s disease (P4.182)Patricio Chrem Mendez, Ismael Calandri, Ignacio Demey, Lucia Pertierra, Maria Julieta Russo, Ezequiel Surace, Horacio Martinetto, Jorge Campos, Silvia Vazquez, Gustavo Sevlever, and Ricardo AllegriAuthors Info & AffiliationsApril 10, 2018 issue90 (15_supplement) Letters to the Editor

10.1212/wnl.90.15_supplement.p4.182

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Activation of protease‐activated receptor‐2 reduces airways inflammation in experimental allergic asthma

Clinical & Experimental Allergy (2007)

Bruno D’Agostino Fiorentina Roviezzo Raffaele De Palma Stefania Terracciano Marilisa De Nardo

Proteinase-activated receptors (PAR)-2 are members of the family of G-protein-coupled receptors activated by proteases. These receptors are widely expressed in several tissues and in virtually all cells involved in rhinitis and asthma. In particular, proteinases activating PAR-2 may affect airway functions and play a role in human diseases.Assessment of the role of PAR-2 in bronchoconstriction, airway responsiveness and immune response after allergic challenge, in rabbits sensitized to Par j 1, the major allergen of Parietaria judaica pollen.Evaluation of antigen challenge in rabbits treated with PAR-2-activating peptide (PAR-2AP) (SLIGRL) or the scrambled peptide LSIGRL or vehicle immediately before allergen exposure measuring airway responsiveness. Characterization of bronchoalveolar lavage (BAL) following histamine challenge and phenotype analysis of cells by flow cytometry and analysis of cytokine production by quantitative PCR.PAR-2AP pre-treatment, but not the scrambled peptide, was able to significantly inhibit bronchoconstriction, airway hyper-responsiveness and to modulate the immune response induced by allergic challenge in sensitized rabbits. The phenotype analysis of the cells recovered from BAL showed an increase in RLA-DR-positive cells while RTLA-positive cells were unchanged. IFN-gamma and IL-2 production were inhibited, with a concomitant increase in IL-10 of about 10-fold over the control values.In this experimental model, PAR-2 modulates bronchoconstriction interfering with antigen challenge-induced immune response in rabbits sensitized and challenged to Par j 1.

Allergic Inflammation

10.1111/j.1365-2222.2007.02793.x

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Citations (34)

Cypress pollen: an unexpected major sensitizing agent in different regions of Italy.

PubMed (2014)

Bruno Sposato Gennaro Liccardi María Julieta Russo Ilenia Folletti Andrea Siracusa

In this multicenter survey, we assessed the impact of sensitization to cypress in atopic patients in Italy and determined whether cypress pollen concentration changed over time.Allergists were required to collect the results of 100-200 consecutive skin prick tests (SPTs) performed during 2012. Seasonal symptoms were also recorded, as were airborne cypress pollen concentrations (data from the Italian Aerobiology Association) in 1998-2000 and 2010-2012.We examined 2258 atopic outpatients (56% females; age, 2-84 years) sensitized to at least 1 of the aeroallergens tested (Dermatophagoides species, grass, pellitory, olive, cypress, birch, Alternaria tenuis, and dog and cat dander). We found that 62.9%, 16.1%, and 32.7% of patients living in central, northern, and southern Italy, respectively, were sensitized to cypress (P < .0001). The cypress pollen concentration peak was delayed from February to March in 1998-2000 and 2010-2012 in all 3 regions, with a shift in pollination towards spring. Patients who were monosensitized to cypress reported mainly rhinitis (90.7%-97.6%) and conjunctivitis (38.1%-100%). In polysensitized patients, the prevalence of rhinitis, conjunctivitis, and asthma increased progressively (P < .0001) from southern to northern Italy. The same trend was observed for the prevalence of reported winter symptoms typical of cypress allergy (28%-65%).Today, cypress pollen is the most frequent sensitizing aeroallergen (assessed by SPT) in several areas of central Italy. Variations in the timing of the cypress pollination period may have favored this increased sensitization. Rhinitis and conjunctivitis are the predominant symptoms. The clinical impact of this allergy was poor in southern Italy and increased in central areas before reaching its peak in northern regions.

Cypress

Cupressus

Aeroallergen

Aerobiology

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Citations (18)

MRI Volumetric Analysis, Cognitive Profiles And Biomarkers In A Sample Of Argentina -ADNI Patients (P3.211)

Neurology (2014)

Marcos Fernández Suarez Griselda Russo Patricio Chrem Méndez Fernando Ventrice Ezequiel Surace

OBJECTIVE: Our goal was to analyze MRI brain volumetry and its correlation to clinical impairment, cognitive profiles and other Alzheimer's disease (AD) biomarkers in order to determine useful clinical volumetric cutoff points. BACKGROUND: According to the pathological stages described by Braak and Braak (1991), hippocampic atrophy is one of the earliest findings in AD. MRI volumetry is a low-cost in vivo study to quantify brain atrophy. In contrast to MRI, CSF biomarkers and PET imaging are restricted to small groups of patients. The relationship between multiple AD biomarkers and its relative usefulness is not yet clear. Our evaluation of peer review literature led us to believe that a careful quantitative analysis of brain volumetry in selected patients could make the use of other AD biomarkers unnecessary. DESIGN/METHODS: 45 patients of the Argentina-ADNI database were included (12 controls, 12 early MCI (eMCI), 13 late MCI (lMCI) and 8 dementia AD). All of them had a baseline MRI Brain Volumetry including Absolute Hippocampal volume, whole brain volume and a hippocampal/whole brain ratio (Hi/WBV). A baseline neuropsychological assessment was performed (According ADNI protocol). PET-FDG, PET-Pib, CSF biomarkers. RESULTS: No significant differences between right and left hippocampus were detected. Whole brain volume was similar between groups, but hippocampal volume was inversely related to clinical impairment. Specially Hi/WBV ratio. 88% of AD, 46% of LMCI and 42% of eMCI were below a cutoff point of 0.0025. In addition, 92% of control patients had a Hi/WBV superior to 0.0025 value. On the other hand, 68.4% of patients who had Hi/WBV<0.0025 had another positive AD biomarker (FDG-PET, Pib-PET or CSF profile) versus 34,6% of those >0.0025. A quantitative measurement of hippocampal metabolism (FDG-PET) showed a direct correlation between clinical impairment and hippometabolism. CONCLUSIONS: A reliable cutoff point to measure hypocampal atrophy could be determined using MRI volumetry, this findig correlates with clinical impairment and the presence of other AD biomarkers.

Sample (material)

10.1212/wnl.82.10_supplement.p3.211

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Music Based Assessment for Cognitive Functions for Spanish-Speaking Adults With Acquired Brain Injury (ECMUS): A Pilot-Validation Study.

PubMed (2021)

Camila F. Pfeiffer Suzanne B. Hanser María Julieta Russo Mercedes Goyheneix Miguel Oliva

Acquired brain injury (ABI) commonly causes cognitive dysfunction that needs to be assessed and treated to maximize rehabilitation outcomes. Research suggests that music, emotion, and cognition are intimately linked, and that music can contribute to the assessment and treatment of cognitive functions of adults who have suffered from ABI. To this date, no standardized music based assessment tool exists to identify and measure cognitive functioning and mood states of Spanish-speaking persons with ABI at treatment intake and over time. The objective of this study was to develop such a scale and determine its psychometric properties in terms of internal consistency, reliability, and concurrent validity. The "Evaluación de la Cognición Musical para Adultos con Lesión Cerebral Adquirida" (in English "Music Based Assessment for Cognitive Functions of Adults with Acquired Brain Injury - ECMUS") was developed and tested at a neurorehabilitation institute in Argentina. Twenty-four healthy adults and 20 adults with ABI were recruited and assessed with the ECMUS. Despite the limited number of participants, this preliminary psychometric examination shows promising results. The tool has an acceptable internal consistency, excellent test-retest and inter-rater reliability, and, depending on the subscale, weak to strong correlations to related, nonmusical constructs. Overall, this pilot study opens the possibility to further explore the inclusion of music in assessment procedures of Spanish-speaking individuals with ABI in rehabilitation settings. It is clinically derived and emphasizes evidence-based contributions of the field of music therapy to interdisciplinary assessment and treatment in rehabilitation settings.

Neurorehabilitation

Acquired brain injury

Music Therapy

Cognitive rehabilitation therapy

Cognitive skill

10.1093/jmt/thab011

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Citations (1)

Washing the clothes of cat owners is a simple method to prevent cat allergen dispersal

Journal of Allergy and Clinical Immunology (1998)

Gennaro Liccardi María Julieta Russo Domingo Barber J. Carreira Maria D’Amato

SOCKS

10.1016/s0091-6749(98)70065-x

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Citations (21)

Measurement of serum levels of eosinophil cationic protein to monitor patients with seasonal respiratory allergy induced by Parietaria pollen (treated and untreated with specific immunotherapy)

Allergy (1996)

Gennaro D’Amato Gennaro Liccardi María Julieta Russo Maria Saggese Maria D’Amato

This trial studied the behavior of a marker of eosinophilic inflammation, eosinophil cationic protein (ECP), in the peripheral blood of two groups of subjects with seasonal allergic respiratory symptoms (rhinitis and mild bronchial asthma) induced by pollen allergens of Parietaria, judaica ( P.j .) (one group treated and another untreated with specific immunotherapy [SIT]), to determine what contribution these serial measurements might provide, in comparison with various other tools now available for pollinosis monitoring. In a previously randomized order, we selected 25 patients with monosensitization to P.j . pollen allergens; among them, 12 had started SIT with a P.j . extract in autumn 1993. As a control group, 13 patients were untreated. All patients were studied with various tests at four different times: time I ‐ November 1993; time II ‐ February 1994; time III ‐ end of May 1994; and time IV ‐ September 1994. Blood samples for determination of serum ECP were collected at each time. Methacholine challenge tests were performed at times I and III. A pollen count was also carried out. A statistically significant difference (P<0.05) was observed in mean ECP levels at times I and 111 in SIT treated and untreated patients. The interaction between groups and time was not significant. No statistically significant difference was found between PD 20 FEV 1 values at times I and III in either group. After 1 year of treatment, we did not find any effect of SIT on bronchial hyperresponsiveness or on ECP serum values.

Methacholine

Bronchial hyperresponsiveness

10.1111/j.1398-9995.1996.tb04600.x

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Citations (22)

Discriminability index as a possible measure of Alzheimer’s disease progression validated using the Alzheimer’s Disease Neuroimaging Initiative database (P5.191)

Neurology (2018)

María Julieta Russo Gabriela Cohen Jorge Campos Ricardo Allegri

April 26, 2018April 10, 2018Free AccessDiscriminability index as a possible measure of Alzheimer’s disease progression validated using the Alzheimer’s Disease Neuroimaging Initiative database (P5.191)Maria Julieta Russo, Gabriela Cohen, Jorge Campos, and Ricardo F. AllegriAuthors Info & AffiliationsApril 10, 2018 issue90 (15_supplement) Letters to the Editor

10.1212/wnl.90.15_supplement.p5.191

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