M. Khaled El‐Yousef

Vanderbilt University

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David S. Janowsky

University of California, San Diego

H J Sekerke

Research Institute for Fragrance Materials

John M. Davis

University of Illinois Chicago

D. Hal Manier

Vanderbilt University

Jack E. Rosenblatt

St. Elizabeths Hospital

John M. Davis

Mayo Clinic in Arizona

William E. Bakewell

University of North Carolina at Chapel Hill

JohnM. Davis

University of Illinois Chicago

DavidS. Janowsky

University of California, San Diego

JM Davis

Southern Illinois University Carbondale

Cooperative Institutions

Vanderbilt University

University of North Carolina at Chapel Hill

University of California, San Diego

National Institute of Mental Health

United States Department of Veterans Affairs

University of Illinois Chicago

University of South Carolina

National Institutes of Health

Vanderbilt University Medical Center

Neuropsychiatric Research Institute

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Combined Anticholinergic Agents and Atropine-Like Delirium

American Journal of Psychiatry (1972)

David S. Janowsky John David M. Khaled El‐Yousef H. JOSEPH SERKERKE

10.1176/ajp.129.3.360-a

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Citations (8)

Interpersonal Maneuvers of Manic Patients

FOCUS The Journal of Lifelong Learning in Psychiatry (2003)

David S. Janowsky M. Khaled El‐Yousef John M. Davis

Manic patients, excited schizoaffective patients, and agitated schizophrenic patients were rated using a “manic interpersonal interaction scale” that evaluated a number of interpersonal interactions including testing of limits, projection of responsibility, sensitivity to others’ soft spots, attempts to divide staff, flattering behavior, and ability to evoke anger. Manic patients showed an elevation in each of these items; overall, elevations were greater than those of schizoaffective and schizophrenic patients. The intensity of the manic state also correlated with the degree of elevation of the manic interpersonal interaction scale scores.

10.1176/foc.1.1.58

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Citations (2)

Letter: Tricyclic antidepressants and phenothiazines

JAMA (1974)

M. Khaled El‐Yousef

Tricyclic

10.1001/jama.229.11.1419b

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Citations (20)

Interaction of physostigmine and delta‐9‐tetrahydrocannabinol in man

Clinical Pharmacology & Therapeutics (1975)

Frank R. Freemon Jack E. Rosenblatt M. Khaled El‐Yousef

To investigate the hypothesis that delta‐9‐tetrahydrocannabinol (THC), the major psychoactive ingredient of marihuana, acts by interfering with cholinergic brain mechanisms, 0.75 to 1.25 mg of physostigmine, a centrally active cholinergic drug, was given intravenously to 5 normal volunteers who had ingested 20 to 40 mg of THC 2 hours earlier. Physostigmine decreased the degree of tachycardia and conjunctival injection produced by THC. The major psychologic effects of physostigmine were amplification of the lethargy and somnolence which occur late in the course of THC intoxication. We interpret the lack of physostigmine counteraction of the peak psychologic effects of THC as evidence against the hypothesis that THC acts predominantly by an anticholinergic mechanism.

Physostigmine

Delta-9-tetrahydrocannabinol

Tetrahydrocannabinol

10.1002/cpt1975172121

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Citations (21)

Diagnosis of Cryptococcal Meningitis

New England Journal of Medicine (1972)

David S. Janowsky M. Khaled El‐Yousef JM Davis H J Sekerke D R Morris

Cryptococcal meningitis

10.1056/nejm197204062861425

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Citations (24)

Rapid tolerance to the motor effects of p-chloroamphetamine in rats

Psychopharmacology (1977)

M. Khaled El‐Yousef Larry R. Steranka Elaine Sanders‐Bush

P-Chloroamphetamine

Drug tolerance

Stimulant

10.1007/bf01457844

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Citations (6)

Antagonism of Guanethidine by Chlorpromazine

American Journal of Psychiatry (1973)

David S. Janowsky M. Khaled El‐Yousef John M. Davis William E. Fann

Chlorpromazine was found to reverse the antihypertensive effects of guanethidine six times in use with four moderately or severely hypertensive psychiatric patients. Haloperidol and thiothixene caused similar effects. It is postulated that this drug-drug interaction occurs because chlorpromazine blocks the neuronal amine-guanethidine uptake pump, thereby denying guanethidine access to its site of action.

Guanethidine

10.1176/ajp.130.7.808

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Citations (26)

Cholinergic antagonism of methylphenidate-induced stereotyped behavior

Psychopharmacology (1972)

D. S. Janowksy M. Khaled El‐Yousef J M Davis H J Sekerke

Physostigmine

Stereotypy

10.1007/bf00429382

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Citations (76)

Stress Polycythemia—A Pathophysiologic Study

Southern Medical Journal (1975)

M. Khaled El‐Yousef William E. Bakewell

Two patients with "Gaisböck syndrome" (stress polycythemia) were found to have been under chronic "stress" with REM sleep decrease, decreased nocturnal ADH-like activity and consequent nocturnal water loss. The role of REM decrease with chronic "stress" in causing secondary decrease in nocturnal ADH-like activity was emphasized as the means by which "stress" caused the blood volume changes seen with these two patients. Some factors that possibly could play a role in the pathophysiology of this syndrome were ruled out and other factors not studied here were considered for future investigation.

Pathophysiology

Chronic Stress

10.1097/00007611-197505000-00010

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Citations (2)

Estrogen Effects on Phenothiazine Derivative Blood Levels

JAMA (1974)

M. Khaled El‐Yousef

To the Editor.— A patient having morning sickness developed a dystonic reaction with a single dose of prochlorperazine (Compazine). Estrogens are reportedly increased during that time of pregnancy, and their possible influence on such a reaction was entertained. Utilizing a dependable and sensitive fluorometric method for the assay of plasma butaperazine, 1 the effects of conjugated estrogens on plasma levels of this phenothiazine derivative were studied. Four postmenopausal female schizophrenic patients, having normal blood chemistry (automated multiple analysis system), thyroid, and liver function tests, and following a week on no medication, were randomly assigned to either a seven-day control period of receiving no hormone, or an experimental period of receiving conjugated estrogens (Premarin), 1.25 mg daily, with a crossover design that used subjects as their own controls. On the seventh day of each period, a single oral dose of 40 mg of butaperazine was given to subjects who had fasted

10.1001/jama.1974.03230320015012

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Citations (5)