Susan Ienne

Universidade de São Paulo

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Tiago Antônio de Souza

Universidade de São Paulo

Nilton Lincopán

Universidade de São Paulo

Louise Cerdeira

Liverpool School of Tropical Medicine

Bianca Zingales

Universidade de São Paulo

Miriam R. Fernandes

Universidade de São Paulo

Doroti de Oliveira Garcia

Instituto Adolfo Lutz

Gabriela Rodrigues Francisco

Fleury S.A. (Brazil)

Quézia Moura

Instituto Federal do Espírito Santo

Maria Fernanda Campagnari Bueno

Biocor Institute

Herbert Serafim

Universidade de São Paulo

Cooperative Institutions

Universidade de São Paulo

Universidade Brasil

Universidade Federal de São Paulo

Hospital Universitário da Universidade de São Paulo

Instituto Butantan

University of Edinburgh

Universidade Federal de Minas Gerais

Fundação Oswaldo Cruz

Universidade Estadual Paulista (Unesp)

Universidade de Ribeirão Preto

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Genomic organization and transcription analysis of the 195-bp satellite DNA in Trypanosoma cruzi

Molecular and Biochemical Parasitology (2008)

Camila Martins Cassio Silva Baptista Susan Ienne Gustavo Cerqueira Daniella Castanheira Bartholomeu

Satellite DNA

Repeated sequence

Minisatellite

Synteny

genomic DNA

Transcription

10.1016/j.molbiopara.2008.03.004

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Citations (32)

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

Memórias do Instituto Oswaldo Cruz (2015)

Bianca Zingales Rafael Gomes Aquino Araujo Margoth Moreno Jaques F. de Carvalho Pedro Henrique Nascimento de Aguiar

Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzistrains. ATP-binding cassette (ABC) transporters are involved in a variety of translocation processes and some members have been implicated in drug resistance. Here we report the characterisation of the first T. cruzi ABCG transporter gene, named TcABCG1, which is over-expressed in parasite strains naturally resistant to BZ. Comparison ofTcABCG1 gene sequence of two TcI BZ-resistant strains with CL Brener BZ-susceptible strain showed several single nucleotide polymorphisms, which determined 11 amino acid changes. CL Brener transfected with TcI transporter genes showed 40-47% increased resistance to BZ, whereas no statistical significant increment in drug resistance was observed when CL Brener was transfected with the homologous gene. Only in the parasites transfected with TcI genes there was 2-2.6-fold increased abundance of TcABCG1transporter protein. The analysis in wild type strains also suggests that the level of TcABCG1 transporter is related to BZ natural resistance. The characteristics of untranslated regions of TcABCG1genes of BZ-susceptible and resistant strains were investigated by computational tools.

Benznidazole

Kinetoplastida

Efflux

10.1590/0074-02760140407

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Citations (58)

ABCG-like transporter of Trypanosoma cruzi involved in benznidazole resistance: Gene polymorphisms disclose inter-strain intragenic recombination in hybrid isolates

Infection Genetics and Evolution (2015)

Jaques F. de Carvalho Renata C. Ferreira Susan Ienne Bianca Zingales

Benznidazole

Subclade

10.1016/j.meegid.2015.01.030

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Citations (29)

Draft genome sequence of an environmental multidrug-resistant Klebsiella pneumoniae ST340/CC258 harbouring bla CTX-M-15 and bla KPC-2 genes

Journal of Global Antimicrobial Resistance (2017)

Louise Cerdeira Miriam R. Fernandes Susan Ienne Tiago Antônio de Souza Doroti de Oliveira Garcia

Lineage (genetic)

Sequence (biology)

10.1016/j.jgar.2016.12.001

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Citations (12)

Draft genome sequence of a multidrug-resistant CMY-2-producing Salmonella enterica subsp. enterica serovar Minnesota ST3088 isolated from chicken meat

Journal of Global Antimicrobial Resistance (2016)

Quézia Moura Miriam R. Fernandes Louise Cerdeira Susan Ienne Tiago Antônio de Souza

Salmonella enterica

10.1016/j.jgar.2016.10.011

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Citations (9)

Draft Genome Sequence of a Hospital-Associated Clone of Klebsiella pneumoniae ST340/CC258 Coproducing RmtG and KPC-2 Isolated from a Pediatric Patient

Genome Announcements (2016)

Louise Cerdeira Miriam R. Fernandes Gabriela Rodrigues Francisco Maria Fernanda Campagnari Bueno Susan Ienne

We report here the draft genome sequence of a Klebsiella pneumoniae strain 1194/11, belonging to the hospital-associated sequence type 340 (ST340; clonal complex CC258), isolated from a catheter tip culture from a pediatric patient. The multidrug-resistant strain coproduced the 16S rRNA methyltransferase rRNA RmtG and β-lactamases KPC-2 and CTX-M-15.

clone (Java method)

10.1128/genomea.01130-16

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Citations (8)

Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures

Epilepsy & Behavior (2020)

Mariana de Souza Aranha Garcia-Gomes Dennis Albert Zanatto Orfa Yineth Galvis‐Alonso Jorge Mejı́a Ana Tada Fonseca Brasil Antiorio

Neurochemical

10.1016/j.yebeh.2020.106945

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Citations (9)

Draft genome sequence of a multidrug-resistant Aeromonas hydrophila ST508 strain carrying rmtD and bla CTX-M-131 isolated from a bloodstream infection

Journal of Global Antimicrobial Resistance (2017)

Quézia Moura Miriam R. Fernandes Louise Cerdeira Ana Carolina de Mello Santos Tiago Antônio de Souza

Strain (injury)

Sequence (biology)

Bloodstream infection

10.1016/j.jgar.2017.07.007

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Citations (13)

A genetic cluster of patients with variant xeroderma pigmentosum with two different founder mutations

British Journal of Dermatology (2016)

Veridiana Munford Ligia Pereira Castro Ricardo Peres do Souto Letícia Koch Lerner Juliana Brandstetter Vilar

Xeroderma pigmentosum (XP) is a rare human syndrome associated with hypersensitivity to sunlight and a high frequency of skin tumours at an early age. We identified a community in the state of Goias (central Brazil), a sunny and tropical region, with a high incidence of XP (17 patients among approximately 1000 inhabitants).To identify gene mutations in the affected community and map the distribution of the affected alleles, correlating the mutations with clinical phenotypes.Functional analyses of DNA repair capacity and cell-cycle responses after ultraviolet exposure were investigated in cells from local patients with XP, allowing the identification of the mutated gene, which was then sequenced to locate the mutations. A specific assay was designed for mapping the distribution of these mutations in the community.Skin primary fibroblasts showed normal DNA damage removal but abnormal DNA synthesis after ultraviolet irradiation and deficient expression of the Polη protein, which is encoded by POLH. We detected two different POLH mutations: one at the splice donor site of intron 6 (c.764 +1 G>A), and the other in exon 8 (c.907 C>T, p.Arg303X). The mutation at intron 6 is novel, whereas the mutation at exon 8 has been previously described in Europe. Thus, these mutations were likely brought to the community long ago, suggesting two founder effects for this rare disease.This work describes a genetic cluster involving POLH, and, particularly unexpected, with two independent founder mutations, including one that likely originated in Europe.

Founder effect

10.1111/bjd.15084

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Citations (27)

Alteration of hippocampal Egr3, GABA A receptors, Il-1β, Il6 and Ccl3 expression in audiogenic tremor mice after seizure

Epilepsy & Behavior (2022)

Mariana de Souza Aranha Garcia-Gomes Pedro Kenzo Yamamoto Sílvia Maria Gomes Massironi Orfa Yineth Galvis‐Alonso Jorge Mejı́a

Proinflammatory cytokine

10.1016/j.yebeh.2022.108962

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Citations (3)