Juliana de Almeida Pires

Universidade Nove de Julho

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José Antônio Silva

Universidade Nove de Julho

Andrey Jorge Serra

Universidade Federal de São Paulo

Paulo José Ferreira Tucci

Universidade Federal de São Paulo

Eduardo Tadeu Santana

Universidade Nove de Julho

Luciene Reginato Chagas

Universidade do Vale do Paraíba

Ednei L. Antônio

Universidade Federal de São Paulo

Martha Trindade Manchini

Universidade Nove de Julho

Maricília Silva Costa

Universidade do Vale do Paraíba

Eduardo Brigidio

Universidade Nove de Julho

Regiane Santos Feliciano

Universidade Nove de Julho

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Universidade Nove de Julho

Universidade Federal de São Paulo

Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Estadual Paulista (Unesp)

Universidade do Vale do Paraíba

Sociedade Brasileira de Cardiologia

Universidade Federal do Rio Grande do Norte

Universidade Municipal de São Caetano do Sul

Centro Universitário FEI

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Expression of mPGES-1 and IP mRNA is reduced by LLLT in both subplantar and brain tissues in the model of peripheral inflammation induced by carrageenan

Lasers in Medical Science (2014)

Luciene Reginato Chagas José Antônio Silva Juliana de Almeida Pires Maricília Silva Costa

Carrageenan

10.1007/s10103-014-1622-4

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Citations (8)

Abstract 423: Low Level Laser Therapy Stimulates Hypoxia-Inducible Factor Expression and Increases MicroRNA 210 Content after Rat Myocardial Infarction

Hypertension (2014)

José Antônio Silva Regiane Santos Feliciano Andrey Jorge Serra Martha Trindade Manchini Eduardo Tadeu Santana

Low-level laser therapy (LLLT) has been used as an anti-inflammatory alternative treatment in several disease conditions, even when inflammation is a secondary consequence, such as in myocardial infarction (MI). LLLT treatment effectively reduces MI size and attenuates the systolic dysfunction after MI. However, the mechanism by which LLLT is able to protect the remaining myocardium remains unclear. Here, we tested the hypothesis that LLLT might reduce the hypoxia effects generated by MI. To achieve this purpose, we evaluated, after laser irradiation, the modulation of hypoxia-inducible factor (HIF) and microRNA 210 expressions, which are consistently stimulated under hypoxic conditions. We observed that HIF content presented an up-regulation after MI, however, a significant augmented HIF expression was observed after LLLT. Accordingly, micro-RNA 210 expression in the MI remote area increased even further after laser irradiation. Our data suggest that LLLT stimulates HIF expression pathway, increasing hypoxia-induced microRNA 210 content after MI, therefore, highlighting a possible cardioprotective role of LLLT.

Hypoxia

Hypoxia-Inducible Factors

10.1161/hyp.64.suppl_1.423

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