David C. McCullough

Volvo (United States)

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John C. Harbert

Georgetown University Medical Center

Dieter Schellinger

Georgetown University

Herbert J. Manz

Georgetown University Medical Center

Frederick T. Borts

Georgetown University

Edward G. Grant

University of Southern California

Dennis L. Johnson

British Film Institute

Alfred J. Luessenhop

George Washington University

K. N. Sivasubramanian

Saveetha University

Mary Kate Davitt

Georgetown University

John L. Fox

Trinity College Dublin

Cooperative Institutions

Georgetown University

Georgetown University Medical Center

National Institutes of Health

George Washington University

Johns Hopkins University

National Institute of Neurological Disorders and Stroke

Neurological Surgery

Johns Hopkins Hospital

United States Department of Veterans Affairs

Pediatrics and Genetics

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Cisplatin therapy in recurrent childhood brain tumors.

PubMed (1982)

Alina Khan Bernard J. DʼSouza Moody D. Wharam Laurence Champion L. F. Sinks

Twenty-two patients with brain tumors were initially treated with surgery, radiation therapy, and/or adjuvant chemotherapy. Histologic diagnosis included 11 gliomas, seven ependymomas, one dysgerminoma, one teratocarcinoma, one pinealoma, and one small cell tumor. At recurrence, documented on computerized tomographic scan, cisplatin (60 mg/m2/day iv X 2) was given every 3-4 weeks. Seventeen patients received two or more courses and were considered to be evaluable for response. Response parameters included change in the size of tumor on computerized tomographic scan and/or in clinical findings. Four patients had complete response, five had partial response, four had stable disease, and four had disease progression. Toxic effects were manageable. The number of patients with grade 3-4 toxic reactions, by category, were: thrombocytic, ten; leukocytic, four; renal, five; metabolic, four; gastrointestinal, none; and neurologic, seven. Two of the 14 patients tested had grade 3-4 ototoxicity. Acute fluid retention with decreased serum electrolytes and serious but reversible changes in the mental status, which were experienced in earlier patients, decreased in severity with increasing experience of the investigator. In summary, cisplatin appears to be active in a spectrum of brain tumors and should be studied further for therapeutic efficacy.

Brain tumor

Pinealoma

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Citations (100)

Radionuclide tests of cerebral fluid shunt patency.

PubMed (1984)

John C. Harbert David C. McCullough

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Citations (3)

Evolution of Porencephalic Cysts from Intraparenchymal Hemorrhage in Neonates: Sonographic Evidence

Edward G. Grant Michael Alexander Kerner Dieter Schellinger Frederick T. Borts David C. McCullough

Ninety-four low-birth-weight neonates were screened consecutively with real-time sonography for evidence of cerebroventricular hemorrhage. Among them, 13 were found to have intraparenchymal hemorrhage beyond the area of the germinal matrix. Weekly follow-up sonograms revealed progression to porencephaly in every surviving infant. Four different sonographic patterns were observed during the evolution from the original hemorrhage to the porencephalic cyst. The size of the mature porencephalic cyst correlated directly with the size of the intraparenchymal hemorrhage. After ventriculoperitoneal shunting, the porencephalic cysts became smaller or remain unchanged. One small cyst was no longer identified after successful shunting, but reappeared with shunt failure.

Intraparenchymal hemorrhage

Porencephaly

Shunting

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Citations (2)

Prognostic criteria for cerebrospinal fluid shunting from isotope cisternography in communicating hydrocephalus

Neurology (1970)

David C. McCullough John C. Harbert Giovanni Di Chiro Ayub K. Ommaya

Shunting

Communicating hydrocephalus

10.1212/wnl.20.6.594

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Citations (85)

USE OF ULTRASOUND IN THE DIAGNOSIS OF INTRACEREBRAL HEMORRHAGE AND PORENCEPHALIC CYST IN NEONATES

Critical Care Medicine (1981)

Yolande F. Smith K. N. Sivasubramanian Mary Kate Davitt David C. McCullough Edward G. Grant

10.1097/00003246-198103000-00568

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Citations (1)

A History of the Treatment of Hydrocephalus

Fetal Diagnosis and Therapy (1986)

David C. McCullough

At a time when the intrauterine diagnosis of hydrocephalus is commonplace and pioneering efforts of antenatal therapy are evolving, review of the chronology of treatment of this disorder becomes pertinent. The history of therapy of hydrocephalus may be divided into three phases. The first two largely involved accumulation of basic anatomical and pathophysiological information. The last phase dates only from the 1950s and may be considered an era of rapid technical development. This account discloses the obligatory relationship between useful therapy and basic knowledge.

10.1159/000262231

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Citations (26)

Comparison between 131I-IHSA and 169Yb-DTPA for cisternography.

PubMed (1973)

John C. Harbert Virginia Reed David C. McCullough

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Citations (3)

Localized enlargement of the cerebrospinal fluid space demonstrated by cisternography

Neuroradiology (1971)

A. Everette James John C. Harbert F. H. DeLand David C. McCullough F. J. Hodges

Neuroradiology

Posterior fossa

Subarachnoid space

10.1007/bf00337565

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Citations (6)

UNUSUAL CASE OF MULTIPLE CEREBRAL ABSCESSES DISCLOSED BY CT

Journal of Computer Assisted Tomography (1979)

D Demichele G. Lohman M Cerroni Bronwyn E. Hamilton W.J. Norman

DeMichele, D.; Lohman, G.; Cerroni, M.; Hamilton, B.; Norman, W.; Lussenhop, A.; Schellinger, D.; Sinks, L.; McCullough, D.; Pilkerton, R.; Mazziotta, J. Author Information

10.1097/00004728-197908000-00139

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Citations (0)

BRAIN MASS FROM QUANTITATIVE CT

Journal of Computer Assisted Tomography (1979)

David C. McCullough H. K. Huang Peter Weiss Douglas D. Robertson

10.1097/00004728-197908000-00098

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Citations (1)