Zhiyong Zhang

Chinese Academy of Sciences

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Lin Yin

Chinese Academy of Medical Sciences & Peking Union Medical College

Lai Gui

Chinese Academy of Medical Sciences & Peking Union Medical College

Chaofeng Jia

Zhejiang Marine Fisheries Research Institute

Shuyin Chen

Zhejiang Marine Fisheries Research Institute

Xiaojun Tang

Guangdong Academy of Agricultural Sciences

Jinzhong Wang

Harbin Institute of Technology

Hu Wan

Huazhong Agricultural University

Lei Shi

Southern Medical University

Dengmei Fan

Jiangxi Agricultural University

Fei Zhu

National Center for Nanoscience and Technology

Cooperative Institutions

Chinese Academy of Sciences

148

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

Guangxi Medical University

Sichuan University

Peking University

Sun Yat-sen University

Central South University

Beijing University of Agriculture

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High-elevation orogenic plateau influences ecosystems

Research Square (Research Square) (2025)

Zhiyong Zhang Nan Wang Péter Luffi Zhiheng Li Zhiqiang Yu

Abstract The interactions between plate tectonic processes and ecosystems are well-documented, but the precise influence of tectonic evolution on ecosystems remains elusive. This study investigates Jurassic–Cretaceous Northeastern Asia, where the Yanliao and Jehol Biotas flourished amid a prominent tectonic transition from crustal shortening to extension. To explore the impact of these processes on the ecosystem, we use innovative whole-rock geochemical composition-elevation models, alongside a large dataset from Late Triassic–Early Cretaceous arc magmatic rocks, to estimate regional-scale variations in paleo-crustal thickness, paleo-elevation, and paleo-temperature. Our results suggest that during the Jurassic, Northeastern Asia experienced significant crustal thickening, elevation increasing, and inland-ward magmatism due to plate convergence. By the Early Cretaceous, magmatism migrated outboard, driven by Paleo-Pacific slab rollback, leading to differential crustal thickness and elevation across the region. We propose an orogenic plateau with elevations of 2.0–4.5 km and mean annual temperatures of -1.0–12.8°C, creating complex topography that impacted spatiotemporal evolution of regional ecosystems and explains the high-elevation and cold habitats of the Yanliao and Jehol Biotas.

Elevation (ballistics)

10.21203/rs.3.rs-5816615/v1

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Comparison between sustained effects of spray and injection thiamethoxam on apple aphids and non-target insects in apple orchard

Ecotoxicology and Environmental Safety (2020)

Hongru Kou Yanchao Sun Zhaoke Dong Zhiyong Zhang

Spray application is considered to be the most common method of insecticide use in apple orchard, while trunk injection has often be used in labor-intensive areas. Here, a comparison of both methods in aphid control efficiency and non-target effects was conducted. We evaluated the effects of thiamethoxam by either spray or injection on apple aphid Aphis citricola, and examined the temporal dynamic of thiamethoxam in leaves by using residue analysis. Results showed that thiamethoxam had a remarkable suppression effect on Aphis citricola, and both application methods had obvious control efficiency with the highest value above 90%. The control effect of spray method on Aphis citricola reached the maximum at 7 days after application, while that of injection method reached the maximum at 14 days after application. Moreover, the control effect of injection after 14 days and that of spray after 7 days were not significant, suggesting the spray method had a higher quick-acting effect than the injection method, and the two methods had a similar persistence effect. The population dynamics of non-target insects (ladybugs, parasitoid wasps and predatory bugs) showed basically the same as that of blank controlled. The control effect evaluation of thiamethoxam on Aphis citricola suggest that injection treatment was more effective in protecting natural enemies than spray treatment, and thiamethoxam didn't interfere with natural enemies to control Aphis citricola with both two application methods.

Orchard

10.1016/j.ecoenv.2020.111307

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Novel polymorphic EST-derived microsatellite markers for the red-listed five needle pine, Pinus dabeshanensis

Conservation Genetics Resources (2014)

Zhiyong Zhang Binbin Cui Jian‐Feng Mao Xiaoming Pang Hui Liu

10.1007/s12686-014-0329-y

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NEW SWEETPOTATO VARIATION BREEDING BY CLONE OF SOMATIC CELL——BREEDING OF VARIETY LONGSHU 3

Wuyi kexue (2007)

Zhiyong Zhang

Longshu 3 was developed from mutants of Yanshu 5 by means of meristem-tip culture,which was a successful attempt on variation breeding by clone of somatic cell.Longshu 3 participated in Fujian new sweetpotato regional variety test from 1999 to 2000,which was approved by the Fujian Crop Variety Examination Committee in 2002,and participated in country new sweetpotato regional vanriety test from 2004 to 2005.Under the identification of its characteristics,productivity,disease resistance,quality,the variety performs well with the characters of high yield,good quality,high resistance to Fusarrium oxysporum.It has captivating root shape,equal root size and rich nutrition.So it is a suitable for a high quality edible sweetpotato variety.Its spread area is 36,500 hectares in all in Fujian from 2003 to 2005.

New Variety

Hectare

clone (Java method)

Disease resistant

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Baseline clinical and radiographic features are associated with long-term (8 years) signs/symptoms for subjects with diseased temporomandibular joint

Dentomaxillofacial Radiology (2007)

Hiroshi Kurita Shinobu Uehara Cher X. Zhao Zhiyong Zhang Hideki Miyazawa

The purpose of this study was to determine the extent to which baseline clinical and radiographic features were associated with long-term outcomes in patients with temporomandibular joint disorder (TMJD).49 patients with unilateral radiographically proven TMJD were available in this study. Self-reported long-term (mean 96.2 months) outcomes (current joint pain, maximum mouth opening and joint noise) after TMJD treatments were assessed by questionnaire. The impact of multiple initial clinical/radiographic findings (gender, age at first visit, time interval between first visit and questionnaire survey, treatment method, disc displacement, disc morphology, disc mobility, condylar bony change and morphology of the articular eminence) on the long-term outcomes was assessed using stepwise multiple regression and logistic regression analysis.Patient age at the first visit was significantly correlated with current joint pain. Disc mobility and morphology of the articular eminence were significantly correlated with current range of maximal mouth opening.The results of this study suggest that patients who appeared symptomatic at a younger age or who initially had a fixed disc were the most likely to have recurrent or persisting clinical signs/symptoms of TMJD after 8 years.

Temporomandibular Joint Disorder

10.1259/dmfr/46387630

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Platycodin D, a triterpenoid saponin from Platycodon grandiflorum , suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-κB pathway

Journal of Biochemical and Molecular Toxicology (2017)

Zhiyong Zhang Minchao Zhao Wenxuan Zheng Yonghong Liu

This work was undertaken to explore the effects of platycodin D, a triterpenoid saponin from Platycodon grandiflorum, on the growth and invasiveness of human oral squamous cell carcinoma (OSCC). Platycodin D caused a significant, concentration-dependent inhibition of cell viability and induced significant apoptosis in OSCC cells. Moreover, platycodin D significantly inhibited OSCC cell invasion. At the molecular level, platycodin D increased the amounts of IκBα protein and reduced the expression of phosphorylated NF-κB p65, MMP-2, and MMP-9. Ectopic expression of constitutively active NF-κB p65 prevented platycodin D-mediated induction of apoptosis and suppression of invasion in OSCC cells. In vivo studies confirmed that platycodin D retarded the growth of subcutaneous SCC-4 xenograft tumors and reduced phosphorylation of NF-κB p65. Altogether, platycodin D shows inhibitory activity on OSCC growth and invasion through inactivation of the NF-κB pathway and might provide therapeutic benefits in the treatment of OSCC.

Triterpenoid saponin

10.1002/jbt.21934

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DETECTION OF SERUM MARKERS BY SELDI-TOF-MS TECHNOLOGY IN PRIMARY HEPATIC CARCINOMA

Xiandai yufang yixue (2010)

Zhiyong Zhang

[Objective]To explore the difference of proteomic spectra in serum form patients with primary hepatic carcinoma and chronic liver disease,and establish a primary diagnosis model of primary hepatic carcinoma.[Methods]The research applied SELDI-TOF-MS and WCX2 chip to detection the differentially expressed serum proteins of primary hepatic carcinoma and chronic liver disease respectively,and to constitute the decision tree classification model.[Results]Thirty-eight differentially expressed proteins in serum were screened by analysis of proteomic spectra of primary hepatic carcinoma and chronic liver disease.Eleven proteins(M3815,M4678,M4703,M4881,M5304,M5716,M6203,M7789,M7988,M8168,M9312)were obtained for making up patterns with accurate rate of 81.5%(53/65)that was able to class of primary hepatic carcinoma and chronic liver disease correctly.Sensitivity of this model was 81.3%(39/48)and specificity was 82.4%(14/17).[Conclusion]These 11 differentially expressed proteins which hold categorizing significance might have a close correlation with the tumorigenesis and development of primary hepatic carcinoma.

Chronic liver disease

Hepatic carcinoma

Primary (astronomy)

Liver disease

Hepatic Diseases

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Identification of proteasome subunit alpha type-1 as a novel biomarker in HBV-associated hepatocellular carcinoma tissue interstitial fluid by proteomic analysis.

PubMed (2017)

Jian Qin Bingshuang Long Lanying Luo Yi Wei Shiyi Chen

Differentially expressed proteins between HCC TIF and normal interstitial fluid of adjacent nontumor tissues were identified through comparative proteomics approach. Then, two-dimensional gel electrophoresis (2-DE), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), In-Cell Western technique, and reverse transcription-polymerase chain reaction (RT-PCR) were used to verify differentially expressed proteins. As a result, through 2-DE, 69 spots were roughly recognized as differentially expressed protein spots, while 44 proteins were identified as differentially expressed spots through MALDI-TOF-MS. Of the identified differential protein spots, 31 were significant according to the bioinformatics analysis results. Proteasome subunit alpha type-1 (PSMA1) expression was down-regulated in HCC TIF. Thus, PSMA1 is considered as a potential biomarker for HBV-associated hepatocellular carcinoma.

Proteome

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[Effects of 3'-azido-deoxythymidine on telomerase activity and protein expression of hepatocarcinoma cell line SMMC-7721].

PubMed (2006)

Min He Yuyan Jiang Miao Zhu Wei Xiao Jian Qin

The mechanism of inhibiting telomerase activity by telomerase inhibitors is very complex, and involves common actions of many proteins. This study was to investigate the effects of 3'-azido-deoxythymidine (AZT) on telomerase activity and protein expression of hepatocarcinoma cell line SMMC-7721, and explore possible mechanism of inhibiting telomerase activity in SMMC-7721 cells by AZT.Optimized concentration and treatment time of AZT were detected by MTT assay. After treatment with AZT, the telomerase activity in SMMC-7721 cells was detected by real-time fluorescent quantitative TRAP (FQ-TRAP) assay; the apoptosis of SMMC-7721 cells was detected by TUNEL assay and flow cytometry (FCM); the changes of specific proteins were monitored by raman spectra assay and surface-enhanced laser desorption time of flight-mass spectrum (SELDI-TOF-MS) with protein chip assay.The optimized treatment time of AZT was 48 h, and the optimized concentration of AZT was 20 mmol/L. When treated with 20 mmol/L AZT for 48 h, the telomerase activity in SMMC-7721 cells was inhibited by 53.85% of control (P<0.001); apoptotic morphologic changes of SMMC-7721 cells were observed; the apoptosis rate of SMMC-7721 cells was 13.5%; 7 spectral peak of proteins were changed; 24 proteins were up-regulated and 8 were down-regulated in SMMC-7721 cells. All of the 32 distinct proteins were small molecular proteins.AZT can inhibit the telomerase activity and induce apoptosis of SMMC-7721 cells, which is related to specific small molecular proteins.

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Genetic Diversity, Population Structure, and Linkage Disequilibrium of a Core Collection of Ziziphus jujuba Assessed with Genome-wide SNPs Developed by Genotyping-by-sequencing and SSR Markers

Frontiers in Plant Science (2017)

Chen Wu Lu Hou Zhiyong Zhang Xiaoming Pang Yingyue Li

Chinese jujube (Ziziphus jujuba Mill) is an economically important fruit species native to China with high nutritious and medicinal value. Genotyping-by-sequencing (GBS) was used to detect and genotype single nucleotide polymorphisms (SNPs) in a core collection of 150 Chinese jujube accessions and further to characterize their genetic diversity, population structure, and linkage disequilibrium (LD). A total of 4,680 high-quality SNPs were identified, of which 38 sets of tri-allelic SNPs were detected. The average polymorphism information content (PIC) values based on bi-allelic SNPs and tri-allelic SNPs were 0.27 and 0.38, respectively. STRUCTURE and principal coordinate analyses based on SNPs revealed that the 150 accessions could be clustered into two groups. However, neighbor-joining trees indicated the accessions should be grouped into three major clusters. Our data confirm that the resolving power for genetic diversity was similar for the SSRs and SNPs. In contrast, regarding population structure, the resolving power was higher for SSRs than for SNPs. The linkage disequilibrium (LD) pattern in Chinese jujube was investigated for the first time. We observed a relatively rapid LD decay with a short range (approximately 10 kb) for all pseudo-chromosomes and for individual pseudo-chromosomes. Our findings provide important information for future genome-wide association analyses and marker-assisted selective breeding of Chinese jujube.

Linkage Disequilibrium

Ziziphus jujuba

10.3389/fpls.2017.00575

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Citations (79)