Anoosh Naghavi

Zahedan University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Saeedeh Salimi

Zahedan University of Medical Sciences

Minoo Yaghmaei

Shahid Beheshti University of Medical Sciences

Mojgan Mokhtari

Iran University of Medical Sciences

Farzaneh Farajian‐Mashhadi

Zahedan University of Medical Sciences

Kimia Kahrizi

University of Social Welfare and Rehabilitation Sciences

Mohsen Saravani

Zahedan University of Medical Sciences

Marzieh Mohseni

University of Social Welfare and Rehabilitation Sciences

Masoud Garshasbi

Tarbiat Modares University

Milad Khorasani

University of Neyshabur

Hossein Najmabadi

University of Social Welfare and Rehabilitation Sciences

Cooperative Institutions

Zahedan University of Medical Sciences

Tehran University of Medical Sciences

University of Social Welfare and Rehabilitation Sciences

Shahid Beheshti University of Medical Sciences

Iran University of Medical Sciences

University of Tehran

Max Planck Institute for Molecular Genetics

Kerman University of Medical Sciences

Tarbiat Modares University

University of Sistan and Baluchestan

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Lack of relationship between endothelial nitric oxide synthase gene 4b/a and T-786C polymorphisms with preeclampsia in southeast of Iran

Archives of Gynecology and Obstetrics (2011)

Saeedeh Salimi Anoosh Naghavi Mojgan Mokhtari Mehrangiz Noora Minoo Yaghmaei

Human genetics

10.1007/s00404-011-1952-4

Cite

Citations (16)

Association of the osteopontin rs1126616 polymorphism and a higher serum osteopontin level with lupus nephritis

Biomedical Reports (2016)

Saeedeh Salimi Mehrangiz Noora Sima Nabizadeh Mahnaz Rezaei HOSSAIN SHAHRAKI

Osteopontin (OPN) is a chemokine-like glycoprotein that has a prominent role in regulating inflammation and immunity. OPN polymorphisms and elevated OPN levels are associated with systemic lupus erythematosus (SLE) in several populations. The aim of present study was to evaluate the association between the OPN rs1126616 polymorphism and OPN level with SLE susceptibility. A total of 163 SLE patients and 180 age‑, gender‑ and ethnically matched controls were genotyped for the rs1126616 polymorphism by the polymerase chain reaction‑restriction fragment length polymorphism method. Serum OPN levels were assayed by the enzyme‑linked immunosorbent assay. There was no association between the OPN rs1126616 C/T polymorphism and SLE. The frequency of the OPN rs1126616 CT genotype was significantly higher in SLE patients with nephritis compared to SLE patients without nephritis and controls. Additionally, the frequency of TT genotypes was higher in SLE patients with nephritis compared to controls. The serum OPN levels were significantly higher in SLE patients compared to controls (50.6±22 vs. 35.6±15.8 ng/ml, P<0.001). Increased serum OPN levels were observed in SLE patients with lupus nephritis and joint symptoms. There was no correlation between OPN levels and the OPN rs1126616 polymorphism. The present data suggest that the CT and TT genotypes of the OPN rs1126616 polymorphism could be a risk factor for lupus nephritis. The OPN level is associated with SLE and certain SLE manifestations. However, there was no association between the OPN rs1126616 C/T polymorphism and SLE susceptibility.

Osteopontin

Nephritis

10.3892/br.2016.589

Cite

Citations (24)

Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy

Zahedan Journal of Research in Medical Sciences (2013)

Saeedeh Salimi Anoosh Naghavi Zakeri Zahra Sima Nabizadeh Farzaneh Farajian‐Mashhadi

1. Department of Clinical Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran 2. Department of Internal Medicine, Clinical Research Development Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran 3. Department of English, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran 4. Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Medical laboratory

Biomedical sciences

Pharmaceutical Sciences

Source

Cite

Citations (1)

The Association study of eNOS 4a/b and G1190T variant with Iranian male infertility: A case-control study and computational analysis

Meta Gene (2021)

Faramarz Fazeli Milad Heidari Nia Elaheh Hajipour Anoosh Naghavi

10.1016/j.mgene.2021.100971

Cite

Citations (0)

Prevalence of Methylenetetrahydrofolate Reductase C677T Polymorphism in women with Polycystic Ovary Syndrome in southeast of Iran.

PubMed (2015)

Anoosh Naghavi Hossein Mozdarani Masoud Garshasbi Minoo Yaghmaei

One of the notable enzymes in the metabolism of folate is Methylenetetrahydrofolate reductase enzyme, this enzyme is necessary for some biological mechanisms. Mutations in the MTHFR gene could reduce the enzyme activity.

SNP

Source

Cite

Citations (7)

DNA repair (2024)

Amir Hozhabrpour Marzieh Mojbafan Fahimeh Palizban F. Vahidnezhad Saeed Talebi

Disease gene identification

Founder effect

1000 Genomes Project

10.1016/j.dnarep.2024.103633

Cite

Citations (0)

An association study of polymorphisms in the H19 imprinted gene in an Iranian population with the risk of polycystic ovary syndrome

Biology of Reproduction (2020)

Marzieh Ghasemi Milad Heidari Nia Mohammad Hashemi Narjes Keikha Kimia Fazeli

Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies that causes problems in female fertility at the reproductive age. PCOS is a multifactorial disease, with genetic factors playing a crucial role in its development. H19 is a long non-coding RNA (lncRNA) expressed from the maternal chromosome, which is correlated with PCOS. In this study, 115 women suffering from PCOS and 130 healthy women with regular menstrual cycles were recruited as case and control groups, respectively. After the extraction of genomic DNA, the restriction fragment length polymorphism polymerase chain reaction was employed for genotyping of rs2067051G>A and rs3741219T>C. Statistical analysis was done using SPSS package V.22 for Windows. In silico analysis was recruited to determine the effects of SNPs on the secondary structure of gene transcript as well as miRNA binding sites. The obtained data showed that the A allele of rs2067051G>A was associated with the high risk of PCOS (OR = 2.00, 95%CI = 1.38–2.91, P = 0.00). AG and AA genotypes led to a 3.64- and (about) a five-fold increase in the risk of PCOS, respectively (95%CI = 2.02–6.54, P = 0.00, and 95%CI = 1.51–16.52, P = 0.00, respectively). These variants caused a significant increase in the risk of this disorder in all genotype models except in the recessive model. However, no association was found between rs3741219T>C and the increased risk of PCOS, either in the allele or in the genotype models. According to the findings, rs2067051G>A is associated with an increased risk of PCOS in the Iranian population.

Genomic Imprinting

10.1093/biolre/ioaa131

Cite

Citations (10)

XRCC1Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population: A Pilot Study

BioMed Research International (2014)

Saeedeh Salimi Milad Khorasani Ehsan Tabatabai Mahnaz Sandoughi Zahra Zakeri

Evidences are suggesting that DNA damage is implicated in development of systemic lupus erythematosus (SLE). Therefore we focused on two common XRCC1 polymorphisms (Arg399Gln and Arg194Trp) in SLE susceptibility in South East of Iran.Peripheral blood DNA was extracted from 163 SLE patients and 180 healthy controls. PCR-restriction fragment length polymorphism method was used for genotyping of XRCC1 Arg399Gln and Arg194Trp polymorphisms.The frequency of Arg/Gln genotype of the XRCC1 Arg399Gln polymorphism was significantly lower in SLE patients than controls. Moreover, lower frequency of Arg/Gln genotype was found in SLE patients with malar rash compared to patients without this manifestation. No association was observed between XRCC1 Arg194Trp polymorphism and increased risk of SLE in studied population. Haplotype analysis revealed no correlation between four haplotypes of XRCC1 Arg399Gln and Arg194Trp polymorphisms and SLE risk.These findings suggest that XRCC1 399 Arg/Gln heterozygous genotype plays a protective role in SLE susceptibility.

XRCC1

10.1155/2014/492956

Cite

Citations (22)

Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery disease

Pathophysiology (2012)

Saeedeh Salimi Anoosh Naghavi Mohsen Firoozrai Hamid Zand Heidar Tavilani

Nitric oxide (NO) is synthesized from l-arginine by endothelium nitric oxide synthase (NOS3) and plays important roles in many physiologic and pathologic processes. NO involved in the pathogenesis of coronary atherosclerosis. In the present study we hypothesized that polymorphisms of NOS gene might be associated with increased risk of coronary artery disease (CAD) and plasma NO concentrations. The eNOS gene polymorphism was investigated in 241 unrelated CAD patients with positive coronary angiograms and 261 ages matched control subjects without a history of symptomatic CAD. The NOS3 gene polymorphisms were analyzed by RFLP. Plasma NO, lipid profile and other risk factors were also assessed. The genotype frequencies for T-786C polymorphism differed significantly between CAD patients and controls (p=0.041). The mean plasma NO(x) concentrations showed significant differences according to genotypes of T-786C polymorphism in total population only. The mean plasma NO(x) increased in those individuals that are homozygote for C allele in promoter compared with those individuals are heterozygote for this allele and homozygote for T allele in total population and Controls, but no in CAD patients. The present study provides evidences that T-786C polymorphism of the NOS3 gene is associated with CAD. T-786C polymorphism was not associated with increased plasma NO in CAD patients.

Heterozygote advantage

Gene polymorphism

Pathogenesis

10.1016/j.pathophys.2012.04.003

Cite

Citations (26)

The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women

Tumor Biology (2016)

Saeedeh Salimi Azam Hajizadeh Minoo Yaghmaei Sodabeh Rezaie Mahnaz Shahrakypour

Uterine leiomyoma (UL) is a monoclonal tumor which arises from uninhibited proliferation of a single myometrial cell; therefore, the imbalance in cell cycle regulation could be a key event in its development. In the present study, we aimed to assess the association of p21 gene polymorphisms and UL. Genomic DNA was extracted from blood samples of 154 women with UL and 197 age-, BMI-, and ethnically matched controls. p21 C98A (rs1801270) and C70T (rs1059234) polymorphism genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The CA genotype of p21 C98A polymorphism was significantly higher in UL women (28 %) compared to the controls (18 %), and the UL risk was 1.8-fold greater in women with CA genotype compared to CC genotype before and after adjusting for age, BMI, and ethnicity (OR, 1.8 [95 % CI, 1.1 to 3]; P = 0.02). There was no association between the AA genotype of p21 C98A polymorphism and UL. Moreover, the frequency of p21 98A allele was significantly higher in the UL women compared to controls (17 vs. 12 %, p = 0.04). The p21 C70T polymorphism did not correlate with UL before and after adjusting for age, BMI, and ethnicity. There was no difference in haplotype frequency of p21 C70T and C98A polymorphisms between UL patients and the controls. CA genotype of p21 C98A polymorphism may be a risk factor for UL susceptibility; however, p21 C70T polymorphism did not associate with UL.

Gene polymorphism

10.1007/s13277-016-5078-y

Cite

Citations (8)