Tokan HIRANO

Yokohama Municipal Citizen's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Efficacy of FOLFOX4 in patients with hypoalbuminemia or immune impairment

Journal of Clinical Oncology (2009)

M. Shibata Nishikawa Yumiko Tokan HIRANO Seiichi Matsuo H Abe

e15141 Background: The effects of chemotherapeutic agents are understood to be regulated by many factors including tumor factors such as sensitivity to drugs and host factors. Among these host factors, nutritional conditions and immune function of cancer-bearing host has been told to relate the effects of chemotherapy, however, it has not been clarified yet. Methods: We have analysed the relationships between the effects of FOLFOX4 and nutritional markers such as serum albumin concentrations and immunology markers including counts of lymphocytes and neutrophils, the ratios of these counts G/L: granulocytes/lymphocytes) and serum concentrations of immunosuppressive acidic protein (IAP) in the patients with disseminated colorectal cancer who have received FOLFOX4. All these blood examinations were performed before the first administration of FOLFOX4 as a first line chemotherapy in 18 patients with disseminated colorectal cancer. Results: Firstly serum albumin levels have shown significant correlation to lymphocyte counts and did inverse correlation to neutrophil counts and G/L ratios. The albumin levels in the patients with PD of FOLFOX outcome was significantly lower than in the patients with PR(p<0.05) and SD (p<0.05). The lymphocytes counts in the patients with PD were significantly lower than in those with PR (p<0.05) and SD (p<0.05). Neutrophil counts, on the other hand, was significantly higher in the patients with PD than in those with PR (p<0.01) and SD (p<0.05). IAP, have been recognized as a marker of immune-suppression in patients with cancer was higher in the patients with PD. Conclusions: Thus the nutritional status is closely related to the immune status in patients with cancer, and the markers of these conditions may present important informations in prediction of results of cancer chemotherapy. No significant financial relationships to disclose.

Hypoalbuminemia

FOLFOX

Serum Albumin

10.1200/jco.2009.27.15_suppl.e15141

Cite

Citations (0)

Effect of Administration of Sairei-to on Painful Muscle Cramps in Patients with Chronic Liver Disease, Especially with Cirrhosis of the Liver.

Kampo Medicine (1993)

Masahiro Nakao Tokan HIRANO Sadahiko Hiratani Masayoshi Fujisawa Shinobu Saito

慢性肝疾患とくに肝硬変にみられる硬直性有痛性筋痙攣 (こむら返り) に対して柴苓湯5.4～8.1g/日の投与を行った。筋痙攣が全く消失した3例を含めて7例中6例において筋痙攣の頻度の明らかな減少と, 筋痙攣に伴う疼痛の程度の改善を認めた。なお, 有効例においては, いずれも, 柴苓湯投与後2週以内に十分な効果の発現をみている。有効例中著効を示した一例を呈示する。腹部から下肢に至る強い筋痙攣を頻発する71歳, 女性の肝硬変例に柴苓湯の投与を行った。投与開始翌日には, 筋痙攣の消失をみた。その後, 患者自身の判断で服薬を中止したところ, 再び筋痙攣が出現した。柴苓湯の服用を再開すると, 投与再開翌日には筋痙攣は消失した。これらの成績より, 柴苓湯の効果は疑う余地がなく, 慢性肝疾患とくに肝硬変にみられる筋痙攣に対する柴苓湯の投与が非常に有効なことがわかった。

Muscle cramp

Chronic liver disease

Liver disease

10.3937/kampomed.43.539

Cite

Citations (3)