Nieves Abril

University of Córdoba

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Carmen Pueyo

Hospital de l'Esperança

Tamara García‐Barrera

Universidad de Huelva

Juan López‐Barea

University of Córdoba

José Luis Gómez‐Ariza

Universidad de Huelva

Marı́a-José Prieto-Álamo

University of Córdoba

Noelia Morales‐Prieto

University College Cork

Ricardo Fernández-Cisnal

University of Córdoba

María Carmen Collado

Instituto de Agroquímica y Tecnología de Alimentos

J. Pérez

University of Córdoba

Marta Selma‐Royo

Instituto de Agroquímica y Tecnología de Alimentos

Cooperative Institutions

University of Córdoba

Cordoba University

Universidad de Huelva

Consejo Superior de Investigaciones Científicas

Instituto Maimónides de Investigación Biomédica de Córdoba

Universidad de Sevilla

Hospital Universitario Reina Sofía

Universidad de Cádiz

Cancer Research UK Manchester Institute

National Institutes of Health

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Metabolomic alterations and oxidative stress are associated with environmental pollution in Procambarus clarkii

Aquatic Toxicology (2018)

Ricardo Fernández-Cisnal M. A. García-Sevillano Tamara García‐Barrera José Luis Gómez‐Ariza Nieves Abril

Procambarus clarkii

Sentinel species

10.1016/j.aquatox.2018.10.005

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Citations (39)

Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.

British Journal of Pharmacology (2023)

Noemí Aranda‐Merino Antonio Marín‐Garrido Cristina Román‐Hidalgo María Ramos‐Payán Nieves Abril

Organisms, including humans, are subjected to the simultaneous action of a wide variety of pollutants, the effects of which should not be considered in isolation, as many synergies and antagonisms have been found between many of them. Therefore, this work proposes an in vivo study to evaluate the effect of certain metal contaminants on the bioavailability and metabolism of pharmacologically active compounds. Because the most frequent entry vector is through ingestion, the influence of the gut microbiota and the possible protective effects of selenium has been additionally evaluated.

Diclofenac

Flumequine

10.1111/bph.16312

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Absolute Transcript Expression Signatures of Cyp and Gst Genes in Mus spretus to Detect Environmental Contamination

Environmental Science & Technology (2006)

Julia Ruiz-Laguna Nieves Abril Tamara García‐Barrera José Luis Gómez‐Ariza Juan López‐Barea

We evaluated whether quantitation of mRNA molecules of key genes is a reliable biomonitoring end-point. We examined the Mus spretus expression levels of 19 transcripts encoding different cytochrome-P450s and glutathione transferases. Mice dwelling at the Doñana Biological Reserve were compared to those from an industrial settlement (PS). Metal biomonitoring indicated that PS animals sustained a heavier pollutant burden than those from the reference site. Transcript quantitations showed the following: (i) gender-related differences in the expression of most Cyp and Gst genes; (ii) one PS female displaying much smaller/larger transcript amounts than the remaining females; (iii) the concomitant up-regulation of Cyp1a2, Cyp2a5, Cyp2e1, Cyp4a10, Gsta1, Gsta2, Gstm1, and Gstm2 mRNAs in liver of PS males; and (iv) outstanding qualitative and quantitative differences between the hepatic expression signature of PS males and that promoted by paraquat. We conclude that (i) absolute amounts of transcripts encoding biotransformation enzymes are more potent biomarkers in males than in females, and in liver than in kidney; (ii) individual quantitations prevent biased interpretations by specimens with abnormal expression levels; and (iii) transcript expression signature of PS males is consistent with exposure to a complex profile of organic pollutants, other than oxidative stressors.

10.1021/es060056e

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Citations (41)

Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica

Veterinary Research (2024)

María Teresa Ruiz-Campillo Isabel Pacheco Nieves Abril M.J. Bautista Álvaro Martínez‐Moreno

Abstract Gene expression for Th1/Th2 cytokines (IL-4 and IFN-ɣ), regulatory cytokines (TGF - β and IL - 10) and the transcriptional factor FoxP3 was analyzed in the liver and hepatic lymph nodes (HLN) from sheep immunized with partially protective and non-protective vaccine candidates and challenged with Fasciola hepatica . FoxP3 T cells were also evaluated by immunohistochemistry (IHQ). The most remarkable difference between the partially protected vaccinated (V1) group and the non-protected vaccinated (V2) group was a more severe expansion of FoxP3 T cells recorded by IHQ in both the liver and HLN of the V2 group as compared to the V1 group, whereas no differences were found between the V2 group and the infected control (IC) group. Similar results were recorded for FoxP3 gene expression although significant differences among V1 and V2 groups were only significant in the HLN, while FoxP3 gene expression was very similar in the V2 and IC groups both in the liver and HLN. No significant differences for the remaining cytokines were recorded between the V1 and V2 groups, but in the liver the V2 group shows significant increases of IFN-ɣ and IL-10 as compared to the uninfected control (UC) group whereas the V1 group did not. The lower expansion of FoxP3 T cells and lower increase of IFN-ɣ and IL-10 in the partially protected vaccinated group may be related with lower hepatic lesions and fluke burdens recorded in this group as compared to the other two infected groups. The most relevant change in regulatory cytokine gene expression was the significant increase of TGF-β in the liver of IC, V1 and V2 groups as compared to the UC group, which could be related to hepatic lesions.

10.1186/s13567-024-01308-8

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Citations (1)

Population Genetic Diversity of Quercus ilex subsp. ballota (Desf.) Samp. Reveals Divergence in Recent and Evolutionary Migration Rates in the Spanish Dehesas

Forests (2018)

Á. Fernández i Martí M. Cristina Romero‐Rodríguez Rafael M. Navarro‐Cerrillo Nieves Abril Jesús V. Jorrín–Novo

The Spanish dehesas have been severely affected by human activities that date to the prehistoric period and have suffered accelerated decline since the 1980s. Holm oak (Quercus ilex subsp. ballota (Desf.) Samp.) is a key component of this system, and its acorns provide an important food source for wildlife and domesticated livestock. Our earlier work showed structured variation in acorn morphology and biochemistry. Here, we used chloroplast and nuclear microsatellites to detect genetic structure among populations of Q. ilex from the major biogeographic regions of Andalusia. We found high levels of spatial differentiation with chloroplast DNA indicating little seed dispersal among populations. Spatial differentiation was weaker for nuclear DNA, presumably as a result of more widespread pollen dispersal and its larger effective population size. The Baetic Cordillera (Cádiz) population consistently appeared well separated from populations of the northern Sierra Morena, suggesting that the Guadalquivir Valley has played an important role in determining population divergence. This may be, in part, evolutionary, as suggested by chloroplast DNA, and, in part, a result of human-induced population isolation, as Q. ilex has been removed from the Guadalquivir Valley. Evolutionary gene flow rates were greater than contemporary rates, which were limited to unidirectional gene flow from Córdoba to other populations in the Sierra Morena and, surprisingly, to the southern population at Almería. The inconsistency between evolutionary and recent migration rates suggests an effect of anthropogenic activity over the last few generations of Q. ilex.

Effective population size

Demographic history

Isolation by distance

10.3390/f9060337

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Citations (35)

Mutation spectra analysis suggests that N‐(2‐chloroethyl)‐N′‐cyclohexyl‐N‐nitrosourea‐induced lesions are subject to transcription‐coupled repair in Escherichia coli

Molecular Carcinogenesis (1997)

Raffaella Iannone Alberto Inga Francisco L. Luque‐Romero Paola Menichini Angelo Abbondandolo

Transcription

Nitrosourea

10.1002/(sici)1098-2744(199705)19:1<39::aid-mc6>3.3.co;2-r

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Citations (0)

Immunological comparisons of glutamine synthetases from photosynthetic bacteria

FEMS Microbiology Letters (1987)

Immunidiffusion and titration studies with antibodies against glutamine synthetase of the purple, photosynthetic bacterium Rhodobacter capsulatus E1F1 have been performed to compare the enzyme from different sources. The results obtained suggest that dodecameric glutamine synthetases from bacteria and cyanobacteria are antigenically related. However, there is not a marked antigenic relationship between glutamine synthetase of R. capsulatus and the octameric enzymes of eukaryotes.

Rhodobacter

Rhodospirillaceae

Rhodospirillales

10.1111/j.1574-6968.1987.tb02103.x

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Citations (2)

Pedro Ximenez sun-dried grape must: a dietary supplement for a healthy longevity

Food & Function (2020)

Noelia Morales‐Prieto Paula V. Huertas-Abril Nieves López de Lerma Isabel Pacheco J. Pérez

Sun-dried Pedro Ximénez white grapes must (PXM) is a potent antioxidant that regularizes apoptosis, proliferation, and regeneration of the structure and the function of aged mice liver. PXM consumption contributes to a healthy aging process.

White (mutation)

10.1039/d0fo00204f

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Citations (4)

Mutagenesis in Escherichia coli lacking catalase

Environmental and Molecular Mutagenesis (1990)

Nieves Abril Carmen Pueyo

Abstract Escherichia coli K‐12 strains completely lacking catalase activity due to mutations in katG , katE , and katF genes were constructed in order to assess the role of hydrogen peroxide in mutagenesis. Mutagenesis was monitored by selecting forward mutations to L‐arabinose resistance. Lethality was measured at experimental conditions equivalent to those of the mutant yield by using a mixed culture of pairs of isogenic strains distinguished by their differential nutritional requirements. Deficiency in katG , katE , and katF genes leads to an enhanced spontaneous mutation rate as well as an enhanced sensitivity to both the lethal and mutagenic effects of hydrogen peroxide or an H 2 O 2 ‐generating mixture of compounds, such as coffee. To compare further the responses of the catalase‐deficient bacteria to those of catalase‐proficient counterparts, other genotoxins were analyzed. Both catalase‐deficient and catalase‐proficient strains were equally mutated by MMS, 4‐NQO, and ultraviolet light. It is concluded that the bacterial strains and the mutagenicity tests described in the paper represent a useful tool to study the role of H 2 O 2 in mutagenesis.

10.1002/em.2850150403

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Citations (31)

Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice

Food and Chemical Toxicology (2019)

Noelia Morales‐Prieto Nieves López de Lerma Isabel Pacheco Paula V. Huertas-Abril J. Pérez

Liver damage

10.1016/j.fct.2019.110984

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Citations (2)