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Túlio M. Graziottin

Universidade Federal de Ciências da Saúde de Porto Alegre

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Cláudio Telöken

Fundação Faculdade de Medicina

Shahram S. Gholami

American Association of Neurological Surgeons

Carlos Teodósio Da Ros

Pontifícia Universidade Católica do Rio Grande do Sul

Júlio Resplande

Instituto de Gastroenterologia de Goiânia

Tom F. Lue

University of California, San Francisco

Tom F. Lue

University of California, San Francisco

Patrick Telöken

Memorial Sloan Kettering Cancer Center

Quan‐Yang Duh

University of California, San Francisco

Paulo Roberto Sogari

Irmandade da Santa Casa de Misericórdia de São Paulo

Ching‐Shwun Lin

University of California, San Francisco

Cooperative Institutions

Tulane University

University of California, San Francisco

Universidade Federal de Ciências da Saúde de Porto Alegre

University of New Orleans

Hospital Moinhos de Vento

Santa Casa Hospital

Fundação Faculdade de Medicina

Mayo Clinic

Universidade de São Paulo

Universidade Federal do Rio Grande do Sul

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Overactive Bladder: Prevalence and Implications in Brazil

European Urology (2006)

Cláudio Telöken Fernanda Caraver Fernanda A. Weber Patrick Telöken João Feliz Moraes

10.1016/j.eururo.2006.01.026

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Citations (89)

Long-Term Effect of Ovariectomy and Simulated Birth Trauma on the Lower Urinary Tract of Female Rats

The Journal of Urology (2002)

Júlio Resplande Shahram S. Gholami Túlio M. Graziottin RODMAN ROGERS Ching‐Shwun Lin

10.1097/00005392-200207000-00099

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Citations (9)

Re: Transperitoneal Preperitoneal Laparoscopic Lumbar Incisional Herniorrhaphy

The Journal of Urology (2002)

Bijan Shekarriz Túlio M. Graziottin Shahram S. Gholami Hengxiao Lu Hiroyuki Yamada

No AccessJournal of UrologyCLINICAL UROLOGY: Letters to the Editor1 Apr 2002Re: Transperitoneal Preperitoneal Laparoscopic Lumbar Incisional Herniorrhaphy B. Shekarriz, T.M. Graziottin, S. Gholami, H.-F. Lu, H. Yamada, Q.-Y. Duh, and M.L. Stoller B. ShekarrizB. Shekarriz More articles by this author , T.M. GraziottinT.M. Graziottin More articles by this author , S. GholamiS. Gholami More articles by this author , H.-F. LuH.-F. Lu More articles by this author , H. YamadaH. Yamada More articles by this author , Q.-Y. DuhQ.-Y. Duh More articles by this author , and M.L. StollerM.L. Stoller More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65217-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Transperitoneal Preperitoneal Laparoscopic Lumbar Incisional Herniorrhaphy." The Journal of Urology, 167(4), p. 1800 © 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 167Issue 4April 2002Page: 1800 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.MetricsAuthor Information B. Shekarriz More articles by this author T.M. Graziottin More articles by this author S. Gholami More articles by this author H.-F. Lu More articles by this author H. Yamada More articles by this author Q.-Y. Duh More articles by this author M.L. Stoller More articles by this author Expand All Advertisement PDF DownloadLoading ...

10.1016/s0022-5347(05)65217-2

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LOW SERUM TESTOSTERONE LEVELS ARE ASSOCIATED WITH POSITIVE SURGICAL MARGINS IN RADICAL RETROPUBIC PROSTATECTOMY: HYPOGONADISM REPRESENTS BAD PROGNOSIS IN PROSTATE CANCER

The Journal of Urology (2005)

Cláudio Telöken Carlos Teodósio Da Ros Fernanda Caraver Fernanda A. Weber Ana P. Cavalheiro

It has been reported that more aggressive prostate cancer (PC) can be associated with low serum testosterone levels. The relationship between serum androgens and PC is still not completely understood. In this study we examined the association of prognostic factors in men who underwent radical retropubic (RRP) prostatectomy with low or normal total testosterone.We retrospectively evaluated 64 consecutive patients with localized PC treated with RRP between July 2002 and November 2003. PC was diagnosed by transrectal ultrasonography guided biopsy performed for either a suspicious digital rectal examination or serum prostate specific antigen greater than 4.0 ng/ml. Gleason score was determined in prostatic biopsies. Pathological TNM staging (1997), capsular perforation, seminal vesicle involvement and surgical margin status were determined in all surgical specimens. The threshold for serum total testosterone was 270 ng/dl. In all analyses p <0.05 was considered statistically significant.There were no statistically significant differences among prostate specific antigen, Gleason score (biopsy or specimen), pathological stage, capsular perforation and seminal vesicle involvement. However, patients with low total testosterone had increased positive surgical margins (p = 0.026).Patients with low total testosterone more frequently present with positive surgical margins in RRP specimens. The true association between low testosterone and poor clinical outcome in the long term needs validation in large prospective studies.

Rectal examination

Radical retropubic prostatectomy

Transrectal ultrasonography

Perforation

Nephrology

10.1097/01.ju.0000181818.51977.29

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Citations (113)

Laparoscopic Prostatectomy With Vascular Control for Benign Prostatic Hyperplasia

The Journal of Urology (2002)

Mirandolino Batista Mariano Túlio M. Graziottin Marcos V. Tefilli

10.1097/00005392-200206000-00046

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Citations (34)

1072 TUNICA ALBUGINEA CRURAL GRAFT FOR SEVERE PENILE CURVATURE DUE TO PEYRONIE'S DISEASE: 07 YEARS FOLLOW-UP

The Journal of Urology (2010)

Cláudio Telöken Patrick Telöken Túlio M. Graziottin Caio Schmit Rodrigo Blaya

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie's Disease/Surgical Therapy I1 Apr 20101072 TUNICA ALBUGINEA CRURAL GRAFT FOR SEVERE PENILE CURVATURE DUE TO PEYRONIE'S DISEASE: 07 YEARS FOLLOW-UP Claudio Teloken, Patrick E. Teloken, Tulio Graziottin, Caio Schmit, and Rodrigo Blaya Claudio TelokenClaudio Teloken More articles by this author , Patrick E. TelokenPatrick E. Teloken More articles by this author , Tulio GraziottinTulio Graziottin More articles by this author , Caio SchmitCaio Schmit More articles by this author , and Rodrigo BlayaRodrigo Blaya More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2231AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Surgery management of severe penile deformity due to Peyronie's disease is surgically challenging. Various surgical techniques and graft materials have been used; however most of them exhibited suboptimal long-term results, especially with regard to curvature recurrence and erectile dysfunction, infection and abnormal scars. We first described the use of tunica albuginea crural graft (TACRUG) and present herein the long-term follow-up results, based upon the principle that the graft comes from human in addittion from the same organ. METHODS We conducted a chart review of patients with preserved erectile function or erectile dysfunction (ED) responding to PDE-5 inhibitors who had undergone plaque incision and graft with TACRUG for stable penile deformity precluding vaginal intercourse. The TACRUG is obtained through a 3-cm longitudinal perineal incision. A longitudinal segment of proximal corpus cavernosum 2mm larger than the defect is delimited with methylene blue, preserving the cavernous artery entry point, and carefully removed. A segment of tunica from the contralateral corpus cavernosum may also be retrieved if necessary. The corpus caversonum then is closed with running 4-0 polyglactin suture. Graft is tailored accordin to the gap to be occluded. RESULTS One hundred and two patients with a mean follow up of 78 months (range 12 to 95) were included in this analysis. Mean age was 54 years (range 42 to 75). Intraoperative penile straightening was obtained in 95 % of all cases. Curvature recurrence requiring new procedure 8% OF patients. Penile shortening was observed in 7 patients and 10 reported glans numbness. Out of 74 patients who reported preoperative spontaneous erections 10 developed postoperative ED, 6 responded to PDE-5 inhibitors. Of 16 patients who preoperatively responded to PDE-5 inhibitors, 6 became unresponsive. Overall, 14 patients subsequently underwent penile prosthesis implantation. 81.7% classified the postoperative result as excellent or satisfactory CONCLUSIONS The TACRUG is easily obtained, does not carry the risk of rejection or transmission of infectious diseases, does not add costs and affords satisfactory long-term results. Despite the lack of a control group, based on our experience and published data, the TACRUG seems to be associated with less curvature recurrence and does not appear to increase the risk of ED when compared to other graft materials. Porto Alegre, Brazil© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e418 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.Metrics Author Information Claudio Teloken More articles by this author Patrick E. Teloken More articles by this author Tulio Graziottin More articles by this author Caio Schmit More articles by this author Rodrigo Blaya More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Tunica albuginea (penis)

Penile curvature

Tunica

10.1016/j.juro.2010.02.2231

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Citations (0)

Re: Transperitoneal Preperitoneal Laparoscopic Lumbar Incisional Herniorrhaphy

The Journal of Urology (2002)

B. Shekarriz Túlio M. Graziottin S. Gholami H.-F. Lu H. Yamada

Incisional Hernia

10.1097/00005392-200204000-00063

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VASCULAR ENDOTHELIAL GROWTH FACTOR PROMOTES PROLIFERATION AND MIGRATION OF CAVERNOUS SMOOTH MUSCLE CELLS

The Journal of Urology (2001)

Xiaowei Liu Ching‐Shwun Lin Túlio M. Graziottin Júlio Resplande Tom F. Lue

10.1097/00005392-200107000-00096

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Citations (5)

VASCULAR ENDOTHELIAL GROWTH FACTOR PROMOTES PROLIFERATION AND MIGRATION OF CAVERNOUS SMOOTH MUSCLE CELLS

The Journal of Urology (2001)

Xiaowei Liu Ching‐Shwun Lin Túlio M. Graziottin Júlio Resplande Tom F. Lue

We investigated whether cavernous smooth muscle cells secrete vascular endothelial growth factor (VEGF), how they respond to VEGF and how age affects their ability to secrete and respond to VEGF.Corpus cavernous tissues were isolated from rats of various ages and grown as monolayer cell cultures. Smooth muscle identity was determined by immunofluorescence staining. Secreted VEGF was measured with a VEGF enzyme-linked immunosorbent assay kit. Cell proliferation was assayed with a cell titer kit. Cell migration was measured with Transwell chambers. VEGF receptor (VEGFR) messenger RNA and proteins were identified by reverse transcription-polymerase chain reaction and immunoblotting, respectively.Cavernous smooth muscle cells from young (age 1 week) and old (age 28 months) rats secreted the least amounts of VEGF and those from 16-week-old rats secreted the most. VEGF stimulated the growth of cavernous smooth muscle cells at an optimal concentration of 12.5 ng./ml. At this concentration cavernous smooth muscle cells from 11-week-old and 28-month-old rats showed the highest and lowest growth rates, respectively. The optimal VEGF concentration for cavernous smooth muscle cell migration was 10 ng./ml. At this concentration cells from 4-week-old and 28-month-old rats showed the highest and lowest migratory rates, respectively. The expression of VEGFR-1 appeared to parallel the VEGF regulated growth rates of these cells. VEGFR-2 was undetectable in cavernous smooth muscle cells.Cavernous smooth muscle cells from rats of different ages secreted different amounts of VEGF and showed different abilities to respond to VEGF. Cavernous smooth muscle cells responded to VEGF in terms of cell proliferation and migration. Cavernous smooth muscle cells from rats of different ages expressed different levels of VEGFR-1 but did not express VEGFR-2.

10.1016/s0022-5347(05)66158-7

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Citations (56)

Cell Cycle Markers in the Evaluation of Bladder Cancer

Pathology & Oncology Research (2018)

Jéssica Niederauer Leote da Silva Alana Durayski Ranzi Caroline Trainotti Carvalho Tales Vicente Scheide Yuri Thomé Machado Strey

Adjuvant Therapy

10.1007/s12253-018-0389-5

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Citations (9)