Corinne Faucheux

Inserm

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Pierre Thiébaud

Université de Bordeaux

Nadine Thézé

Université de Bordeaux

Sandrine Fédou

Université de Bordeaux

Jérôme Guicheux

Nantes Université

Jean‐Michel Bouler

Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation

Reine Bareille

Université de Bordeaux

Karine Tréguer

Goethe University Frankfurt

Solen Josse

Université de Picardie Jules Verne

Bruno Bujoli

Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation

G. Daculsi

Inserm

Cooperative Institutions

Inserm

Centre National de la Recherche Scientifique

Université de Bordeaux

Bordeaux Population Health

Nantes Université

Le Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire

Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers

Immunology from Concept and Experiments to Translation

R-

RMeS - Regenerative Medicine and Skeleton

Centre Hospitalier Universitaire de Nantes

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Chemically Modified Calcium Phosphates as Novel Materials for Bisphosphonate Delivery

Advanced Materials (2004)

Solen Josse Corinne Faucheux A. Soueidan G. Grimandi Dominique Massiot

A potent inhibitor for bone resorption, the gem-bisphosphonate zoledronate, has been chemically associated with calcium-deficient apatites. The ability of such materials to release the zoledronate, resulting in the inhibition of osteoclastic resorption, is demonstrated using a specific in-vitro bone resorption model. The resorption activity is typically characterized by the formation of lacunae on the surface of dentin slices (see Figure).

Diphosphonates

10.1002/adma.200306340

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Citations (70)

Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclastic resorption in vitro

Journal of Biomedical Materials Research Part A (2008)

Corinne Faucheux Élise Verron Assem Soueidan Solen Josse M. Arshad

Abstract Calcium phosphate biomaterials such as calcium deficient apatite (CDA) have been contemplated as carrier for delivery of bisphosphonate in bone tissues. In the present work, we have investigated the in vitro biological properties of Zoledronate‐loaded CDA. CDA was loaded with zoledronate according to a previously described coating process. 31 P MAS NMR spectra demonstrated the effective loading of zoledronate onto CDA. Using 14 C labeled zoledronate, we then demonstrated the in vitro release of zoledronate from CDA. In a first set of experiments, we confirmed that Zoledronate reduced the number of TRAP‐, vitronectin receptor‐, and F‐actin ring‐positive cells as well as the resorption activity of osteoclasts obtained from a total rabbit bone cell culture. Interestingly, Zoledronate‐loaded CDA and its extractive solutions decreased the osteoclastic resorption. Finally, zoledronate‐loaded CDA did not affect the viability and alkaline phosphatase activity of primary osteoblastic cells. These data demonstrate that CDA is effective for loading and release of zoledronate. The released zoledronate inhibited osteoclastic resorption without affecting osteoblasts. Our findings therefore suggest that such a drug delivery system would allow an increase in the efficiency of bisphosphonates by being locally available. Further experiments are now required to evaluate the in vivo antiresorptive activity of this concept. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

10.1002/jbm.a.31989

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Citations (63)

Egaliseurs pour des communications radiomobiles a haut debit en milieu interieur

Corinne Faucheux

Les communications radiomobiles a haut debit ( 40 mbits/s) en milieu interieur sont une alternative interessante aux reseaux filaires classiques du fait de leur plus grande flexibilite, de leur faible cout, et de leur facilite d'installation. Cependant, elles sont soumises a de nombreuses reflexions, refractions et diffractions des signaux emis sur les parois environnantes. Au recepteur, ce phenomene se traduit par de l'interference entre symboles (ies) qui rend necessaire l'utilisation d'un egaliseur pour estimer les signaux emis. Dans ce memoire, nous proposons tout d'abord l'utilisation d'un estimateur sequentiel a maximum de vraisemblance (esmv ou mlse en anglais), mais de complexite reduite : l'estimateur sequentiel hybride (esh ou dfse en anglais) qui ne prend pas en compte toute la longueur d'ies dans ses etats. On peut diminuer encore sa complexite en partitionnant l'alphabet des symboles emis : on obtient ainsi l'esh partitionne (eshp ou rsse en anglais). Cependant, pour ces egaliseurs, l'utilisation d'un prefiltre correcteur de phase est necessaire pour atteindre des performances identiques a un esmv. C'est pourquoi nous avons propose l'utilisation d'un estimateur innovant qui prenne en compte intrinsequement la repartition d'energie de la reponse impulsionnelle du canal de transmission et qui ne necessite donc plus de prefiltre correcteur de phase : nous l'avons nomme eshp pondere (ou weighted rsse en anglais).

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Induction and modulation of smooth muscle differentiation in Xenopus embryonic cells

Developmental Dynamics (2008)

Wilfrid Barillot Karine Tréguer Corinne Faucheux Sandrine Fédou Nadine Thézé

Abstract By comparison with skeletal or cardiac developmental programs, little is known regarding the specific factors that promote specification and differentiation of smooth muscle cells from pluripotent cells. We have analyzed the developmental expression of a subset of smooth muscle genes during Xenopus early development and showed that similar to mammals and avians, Xenopus smooth muscle myosin heavy chain ( SM‐MHC ) is a highly specific marker of smooth muscle differentiation. Embryonic cells from animal pole explants of Xenopus blastula can be induced by basic fibroblast growth factor, Wnt, and bone morphogenetic protein signals to adopt the smooth muscle pathway. Explants from early embryos that contain neural crest cells can also differentiate into cells expressing smooth muscle genes. We examined the interplay of several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM‐MHC in animal cap cells and found that myocardin‐dependent expression of smooth muscle genes in animal cap cells is synergized by SRF but is strongly antagonized by GATA6. Developmental Dynamics 237:3373–3386, 2008. © 2008 Wiley‐Liss, Inc.

Myocardin

Blastula

10.1002/dvdy.21749

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Citations (11)

Biocompatibility testing of a bovine hydroxy?apatite ceramic material with the use of osteo-progenitor cells isolated from human bone marrow

Journal of Materials Science Materials in Medicine (1994)

Corinne Faucheux Reine Bareille F. Rouais J. Am�d�e A. Liebend�rfer

Osteonectin

Biocompatibility

Human bone

10.1007/bf00120345

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Citations (30)

Opposing Actions of BMP3 and TGFβ1 in Human Bone Marrow Stromal Cell Growth and Differentiation

Biochemical and Biophysical Research Communications (1997)

Corinne Faucheux F. Ulysse Reine Bareille A. Hari Reddi Joëlle Amédée

BMP3 and TGFβ1 were found to induce opposite effects on human bone marrow stromal cells both in cell proliferation and cell differentiation and on calcium deposition onto the extracellular matrix. Moreover, BMP3 may exert, in part, the inhibitory effect of TGFβ1 through decreasing the affinity of TGF-β for its receptors which are now identified in these human bone cells.

Human bone

Bone cell

10.1006/bbrc.1997.7792

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Citations (23)

MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate

Development (2013)

M. Mathieu Corinne Faucheux Claire Saucourt Fabienne Soulet Xavier Gauthereau

Pluripotent mouse embryonic stem cells (mESCs), maintained in the presence of the leukemia inhibitory factor (LIF) cytokine, provide a powerful model with which to study pluripotency and differentiation programs. Extensive microarray studies on cultured cells have led to the identification of three LIF signatures. Here we focus on muscle ras oncogene homolog (MRAS), which is a small GTPase of the Ras family encoded within the Pluri gene cluster. To characterise the effects of Mras on cell pluripotency and differentiation, we used gain- and loss-of-function strategies in mESCs and in the Xenopus laevis embryo, in which Mras gene structure and protein sequence are conserved. We show that persistent knockdown of Mras in mESCs reduces expression of specific master genes and that MRAS plays a crucial role in the downregulation of OCT4 and NANOG protein levels upon differentiation. In Xenopus, we demonstrate the potential of Mras to modulate cell fate at early steps of development and during neurogenesis. Overexpression of Mras allows gastrula cells to retain responsiveness to fibroblast growth factor (FGF) and activin. Collectively, these results highlight novel conserved and pleiotropic effects of MRAS in stem cells and early steps of development.

MRAS

Homeobox protein NANOG

Rex1

10.1242/dev.091082

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Citations (14)

A Novel Drug Delivery System for Bisphosphonates: Innovative Strategy for Local Treatment of Bone Resorption

Key engineering materials (2005)

Solen Josse Corinne Faucheux Assem Soueidan G. Grimandi Dominique Massiot

One type of potent aminobisphosphonate (Zoledronate) has been chemically associated onto b-tricalcium phosphate [b-TCP] and calcium deficients apatite [CDA]. Two different association modes have been observed, according to the nature of the Calcium Phosphate [CaP] support and/or the initial concentration of the Zoledronate solution. b-TCP appears to promote Zoledronate-containing crystals formation. On the other hand, at concentrations < 0.05 mol.L-1 CDA seems to undergo chemisorption of the drug through a surface adsorption process, due to PO3 for PO4 exchange, which is well described by Freundlich equations. At concentrations > 0.05 mol.L-1, crystalline needles of a Zoledronate complex form onto the CDA surface. The ability of CDA to release Zoledronate, resulting in the inhibition of osteoclastic activity, was shown using a specific in vitro bone resorption model.

10.4028/www.scientific.net/kem.284-286.399

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Citations (4)

Various evaluation techniques of newly formed bone in porous hydroxyapatite loaded with human bone marrow cells implanted in an extra-osseous site

Biomaterials (2000)

Reine Bareille Marie‐Hélène Lafage‐Proust Corinne Faucheux Norbert Laroche R. Wenz

Matrix (chemical analysis)

Biomaterial

10.1016/s0142-9612(00)00015-6

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Citations (37)

CHARACTERIZATION OF A MAMMALIAN SMOOTH MUSCLE CELL LINE THAT HAS RETAINED TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL POTENCIES