Pandemia wywolana przez koronawirusa (SARS-CoV-2) stala sie przyczyną globalnego kryzysu zdrowotnego, ktorego przewidzenie nie bylo w zaden sposob mozliwe. Odkąd w grudniu 2019 roku w Wuhan, w prowincji Hubei w Chinach, odnotowano pierwszy przypadek rozpoznanego zapalenia pluc COVID-19, infekcja szybko rozprzestrzenila sie na caly świat. Wiedza uzyskana na podstawie doświadczen wynikających z epidemii zakazen koronawirusami ludzkimi, ktore mialy miejsce w poprzednich latach, sugeruje, ze kobiety w ciązy oraz ich plody stanowią populacje wysokiego ryzyka podczas epidemii chorob zakaźnych. Ponadto ciąza, ze wzgledu na zachodzące fizjologicznie zmiany związane z ukladem odpornościowym i krązeniowo- -oddechowym, jest stanem predysponującym kobiety do wystepowania powiklan oddechowych związanych z infekcją wirusową. Pomimo stale rosnącej liczby pojawiających sie publikacji dotyczących przebiegu zakazenia COVID-19 u kobiet w ciązy, dostepne dane są nadal ograniczone i wiele pytan pozostaje bez odpowiedzi. Celem tego przeglądu bylo podsumowanie danych literaturowych oraz na bieząco aktualizowanych zalecen dotyczących opieki nad pacjentką w ciązy, w okresie porodu oraz pologu. Niezwykle istotną kwestie stanowi koniecznośc rejestrowania wszystkich przypadkow kobiet ciezarnych dotknietych COVID-19 oraz przebiegu tych ciąz do rejestrow o zasiegu lokalnym, regionalnym czy miedzynarodowym, co bedzie pomocne w udzieleniu odpowiedzi na wiele pytan klinicznych i naukowych oraz stworzeniu wytycznych zapewniających odpowiedni poziom opieki nad kobietami dotknietymi zakazeniem COVID-19 w czasie ciązy, porodu i pologu, a takze nad ich noworodkami.
Introduction: Physical activity during pregnancy is established to derive clinically meaningful improvements in pregnancy, childbirth, and postpartum health outcomes. Evidence-based pre-screening tools have been developed to support the implementation of physical activity programmes, and enhance communication between health care providers, exercise professionals and pregnant women. The Get Active Questionnaire for Pregnancy (GAQ-P) and the Health Care Provider Consultation Form for Prenatal Physical Activity (HCPCF) empower pregnant women to identify whether they require additional counselling from their obstetric health care provider in terms of physical activity. However, these tools are not available in Polish. This work details the process taken to translate the GAQ-P and HCPCF into Polish. Material and Methods: We followed the translation process outlined by the Translation and Cultural Adaptation International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines between August 2022 and August 2023. We formed an expert group that included representatives of the Polish Society of Sports Medicine, The Polish Society of Gynaecologists and Obstetricians, practitioners, and scientists in physical activity during pregnancy. We implemented 9 of the 10 steps recommended by ISOPR in the translation process. At the Cognitive Debriefing stage, we collected opinions on the Polish version of GAQ-P and HCPCF from 70 stakeholders on the clarity and cultural appropriateness of the translation. Results and Conclusions: Target users have positively evaluated the Polish version of GAQ-P and HCPCF. Thanks to the ISPOR methodology, we obtained a trustworthy, evidence-based screening tools, which can reduce the barriers for most women to be physically active during pregnancy.
The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis by simultaneously measuring these parameters in plasma and peritoneal fluid. Ninety women were evaluated, of whom 57 were confirmed as having endometriosis. Lactoferrin was measured by ELISA, transferrin, ferritin and iron on a Cobas 8000 analyser. Lactoferrin and transferrin in peritoneal fluid were lower compared to plasma, in contrast to ferritin and iron. In plasma, lactoferrin showeds associations with iron and transferrin in endometriosis and with ferritin in the group without endometriosis. Lactoferrin in peritoneal fluid correlated with lactoferrin, iron and transferrin of plasma in patients without endometriosis. The ratio of lactoferrin concentration in peritoneal fluid to plasma differentiated stage I versus IV of endometriosis and was negatively correlated with the iron ratio in patients without endometriosis. The ferritin ratio differentiated women with and without endometriosis. The very high ferritin ratios, especially in advanced stages of endometriosis, suggest the protective involvement of this protein in peritoneal fluid and the loss of this role by lactoferrin. The results demonstrate the validity of assessing iron metabolism in women with endometriosis, which may be useful as a marker of the disease and its progression.
The aim of the Guideline is to unify the diagnostic-therapeutic management of multiple-gestation pregnancies complicated by fetal growth restriction in at least one fetus.
Dynamic development of prenatal diagnostics is mostly directed towards search for non-invasive screening. The main role of the screening methods is to select high-risk fetal aneuploidy group of pregnant women. The base for the prenatal screening in modern obstetrics is ultrasound scanning.The aim of the study was to estimate typical value range for the fetal nasal bone length measurement (NB) between 11th and 20th week of pregnancy, in Polish population. The second aim was to assess the value of the parameter as an aneuploidy marker.The study was conducted between 1999-2006, in the 1st Division of Obstetrics and Gynaecology, Medical University in łódź. The investigated population comprised 2960 pregnant women. 53 cases of the fetal chromosomal aneuploidies were diagnosed.Typical values for the nasal bone measurement were estimated. The investigations showed that until 13th gestation week, visualization of the presence or absence of the nasal bone on the ultrasound scan is a better marker for fetal aneuploidy diagnosis than the measurement. However, since the 14th week, it is the measurement that becomes the most adequate method of the fetal nasal bone assessment.(1) We estimated the normal value range for the fetal nasal bone length measurement (NB) between 11 and 20 weeks of pregnancy. (2) The nasal bone length is an useful marker for the fetal aneuploidy. 3. The predictive value of the method suggests the visualization of the nasal bone presence in the 1st trimester of the pregnancy as a screening method. The measurement of the NB proves to be a useful method in the prenatal diagnostic in the 2nd trimester of the pregnancy.
