Shuang Zhang

National Institute for Viral Disease Control and Prevention

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Jiujiang Wang

Criminal Investigation Police University of China

Yuanyu Yu

Neijiang Normal University

Yuping Qin

Neijiang Normal University

Mang I Vai

University of Macau

Chongyang Ma

Capital Medical University

Jin‐Sheng Gao

Heilongjiang University

Fafeng Cheng

Beijing University of Chinese Medicine

Sio Hang Pun

University of Macau

Feng Gao

Shandong University

Wei Mei

Shantou University

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Chinese Academy of Sciences

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Huazhong University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Sun Yat-sen University

Sichuan University

Shanghai Jiao Tong University

Jilin University

Capital Medical University

Chinese Center For Disease Control and Prevention

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Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier

Evidence-based Complementary and Alternative Medicine (2020)

Shuang Zhang Xueqian Wang Fafeng Cheng Chongyang Ma Shuning Fan

Ischemic stroke is the most common type of cerebrovascular accident worldwide. It causes long‐term disability and death. Qingkailing (QKL) injection is a traditional Chinese patent medicine which has been clinically applied in the treatment of ischemic stroke for nearly thirty years. In the present study, network pharmacology combined with experimentation was used to elucidate the mechanisms of QKL. ADME screening and target prediction identified 62 active compounds and 275 targets for QKL. Topological screening of the protein‐protein interaction (PPI) network was used to build a core PPI network consisting of 408 nodes and 17,830 edges. KEGG enrichment indicated that the main signaling pathway implicated in ischemic stroke involved hypoxia‐inducible factor‐1 (HIF‐1). Experimentation showed that QKL alleviated neurological deficits, brain infraction, blood‐brain barrier (BBB) leakage, and tight junction degeneration in a mouse ischemic stroke model. Two‐photon laser scanning microscopy was used to evaluate BBB permeability and cerebral microvessel structure in living mice. HIF‐1 α , matrix metalloproteinase‐9 (MMP‐9), and tight junction proteins such as occludin, zonula occludins‐1 (ZO‐1), claudin‐5, and VE‐Cadherin were measured by western blotting. QKL upregulated ZO‐1 and downregulated HIF‐1 α and MMP‐9. QKL has a multiapproach, multitarget, and synergistic effect against ischemic stroke.

10.1155/2020/2914579

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Citations (9)

Long-term efficacy and anamnestic response of hepatitis B vaccine derived from Chinese hamster ovary cell after 18–20 years

Vaccine (2025)

Qiudong Su Feng Qiu Zhao Gao Yuliang Zhao Jingchen Ma

Hepatitis B vaccine

Hepatitis B

10.1016/j.vaccine.2024.126655

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Impact of IVF/ICSI on Grades of Placenta Accreta Spectrum Disorders and Pregnancy Outcomes

Research Square (Research Square) (2024)

Miao Hu Lili Du Lizi Zhang Lin Lin Yuliang Zhang

Abstract Objective To investigate the impact of IVF/ICSI on grades of placenta accreta spectrum disorders and pregnancy outcomes. Methods Placenta accreta spectrum disorders patients who underwent cesarean section at a single clinical center from January 2018 to March 2023 were retrospectively included in this study. Baseline characteristics and outcomes were compared between the IVF/ICSI group and the spontaneous conception group. Binary logistic regression was used to explore the risk factors associated with adverse outcomes related to IVF/ICSI. A 1:1 ratio propensity score matching (PSM) was conducted to minimize selection bias between the two groups. Data analysis was performed using SPSS (version 25.0) software. Results No increase in the incidence of grades placenta was detected for IVF/ICSI group, and the difference is not statistically significant (P = 0.290). PAS grading is not associated with IVF/ICSI (OR = 0.76, 95%CI: 0.45 ~ 1.27, P = 0.290). In contrast, a significant risk factor for postpartum hemorrhage (OR = 9.20, 95%CI: 2.68 ~ 9.22, P < 0.001) and red cells transfusion ≥ 4U (OR = 3.71,95%CI:1.21 ~ 11.33, P = 0.021) was observed in IVF/ICSI group. No additional adverse pregnancy outcomes arose as a result of IVF/ICSI. Conclusion It is necessary to further investigation into the potential risk factors that might impact PAS grading. It has been shown that IVF/ICSI treatment is associated with a higher risk of postpartum hemorrhage and blood transfusion requirements. Therefore, in order to provide patients the best chance of recovery, professionals must carefully evaluate the patient's health as well as the available treatment options.

Placenta Accreta

10.21203/rs.3.rs-4983277/v1

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Use of Supporting Post Width to Increase the CMUT’s Resonant Frequency

IEEE Access (2022)

Jiujiang Wang Sio Hang Pun Yuanyu Yu Yihe Liu Ching‐Hsiang Cheng

A new method is proposed to increase the resonant frequency of a Capacitive Micromachined Ultrasonic Transducer (CMUT) device while keeping the radii unchanged for devices fabricated by sacrificial release (SR) method. The resonant frequency of a CMUT cell is determined by the properties of the membrane such as the Young’s modulus, membrane dimensions and effective membrane mass. Effective Young’s modulus is used to calculate the resonant frequency of CMUT fabricated by SR method. The supporting post structure will affect the boundary conditions at the edge of the CMUT membrane and in turn affect the deflection together with the effective Young’s modulus of the membrane. The perturbation method is used to derive the solution for the governing von Kármán equations. The results show that the thicker is the supporting post width, the higher is the resonant frequency. This method can also be used to simplify the mask design and CMUT fabrication process.

10.1109/access.2022.3178990

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Citations (4)

Research Rooting Temperature to Liquid Cultivation of Jufeng Grapes

Shuang Zhang

During the liquid cultivation for annually two harvests of Jufeng grapes, the rooting temperature is very important and the key factor to affect the growth Our experienments show that the proper rooting temperature is between 30～330C

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A System Design for DSP + FPGA Based Cache-structured Image Processing

Jinhua Liu Shuang Zhang Shu Li Jing Xiao

This essay presents the DSP + FPGA structure based high-performance image processing system.It aims at solving the overtime-processing problem brought by the increasing complexity of images through the cache-structured image-processing driver.This system allows frame-dropping whenever the processing of images runs overtime and achieves one frame.The system simulation result shows in this way the diver achieves higher efficiency than traditional ping-pong mode when dealing with the overtime-processing of images.

Overtime

Frame rate

10.2991/iccasm.2012.319

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Research on Multi-Objective Minimum Spanning Tree Algorithm Based on Ant Algorithm

Research Journal of Applied Sciences Engineering and Technology (2013)

Yong Li Chuan Yun Zou Shuang Zhang Mang I Vai

The ant algorithm is a branch of the artificial intelligence, which is developed from natural rules and of strong adaptability and expandability. Compared to other conventional algorithms, the algorithm has an unparalleled advantage that is demonstrated on combinatorial optimization problems through its application in the multi-objective minimum spanning tree.

Adaptability

Prim's algorithm

Swarm intelligence

Optimization algorithm

Tree (set theory)

10.19026/rjaset.5.4396

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Citations (5)

A Novel Bayesian Kalman Filter Under Non-Gaussian Noise for Underwater Integrated Navigation

2021 IEEE International Conference on Unmanned Systems (ICUS) (2023)

Haoqian Huang Aoqi Lv Shuang Zhang Rong Qiu

Affected by the complex underwater environment, underwater integrated navigation usually has to face the problem of measurement loss and non-Gaussian noise. To solve these problems, two kinds of novel statistical similarity measure-based Bayesian Kalman filter are proposed. In order to handle with the measurement loss, the proposed SSMBKF-I uses maximum a posterior estimation (MAP) to determine whether a measurement loss has occurred or not. The proposed SSMBKF-II introduces the probability of measurement loss into minimum variance estimation (MVE). Meanwhile, the statistical similarity measure method is employed for handling with the issue of non-Gaussian noise. Through utilizing fixed-point iteration approach to optimize the cost function to its maximum value, the suboptimal state estimation can be obtained. The simulation examples are utilized for evaluating the performance of the SSMBKF-I, SSMBKF-II relative to the Kalman filter, Bayesian Kalman filter and statistical similarity measure based Kalman filter.

Gaussian Noise

10.1109/icus58632.2023.10318326

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Temporal alteration of microglia to microinfarcts in rat brain induced by the vascular occlusion with fluorescent microspheres

Frontiers in Cellular Neuroscience (2022)

Yi Shen Jingjing Cui Shuang Zhang Yuqing Wang Jia Wang

Microglia, the resident immune cells in the central nervous system, can monitor the microenvironment and actively respond to ischemic stroke and other brain injuries. In this procedure, microglia and neurons can cross-talk via transmembrane chemokine, Fractalkine (CX3CL1), to impact one another. We used a rat model of multifocal microinfarcts induced by the injection of fluorescent microspheres into the right common carotid artery and examined the morphological alteration of blood vessels, microglia, astrocytes, and neurons at 6 h, 1, 7, and 14 days after modeling, along with neurobehavioral tests and the staining of CX3CL1 in this study. Our results demonstrated that in the infarcted regions, astrocytes and microglia activated in response to neuronal degeneration and upregulation of cleaved caspase-3, which occurred concurrently with vascular alteration and higher expression of CX3CL1. We provided sequential histological data to shed light on the morphological changes after modeling, which would help in the identification of new targets and the choice of the ideal time window for therapeutic intervention in ischemic stroke.

Stroke

CX3CL1

10.3389/fncel.2022.956342

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4,4′-(o-Phenylenedioxydimethylene)dipyridinium dinitrate

Acta Crystallographica Section E Structure Reports Online (2009)

Ping Zou Shuang Zhang Ying Liu Qiao Jun Jin‐Sheng Gao

The cation of the salt, C(18)H(18)N(2)O(2) (2+)·2NO(3) (-), lies about a twofold rotation axis. The pyridinium ring is almost coplanar with the phenyl-ene ring [dihedral angle between rings = 5.69 (9)°]. The crystal structure shows π-π stacking inter-actions [centroid-centroid distance = 3.70 (1) Å] between the pyridinium rings and the phenyl-ene rings, generating a linear chain structure. The cation also forms two N-H⋯O hydrogen bonds to two nitrate groups.

Dihedral angle

10.1107/s1600536809040215

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