Yang Xiao

Central South University

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Zhiguang Zhou

Shanghai Ocean University

Gan Huang

Second Xiangya Hospital of Central South University

Zhiguo Xie

Central South University

Xia Li

Central South University

Shuoming Luo

Second Xiangya Hospital of Central South University

Aimin Xu

University of Hong Kong

Zhiguang Zhou

Second Xiangya Hospital of Central South University

Xiao‐Jun Huang

Center for Life Sciences

Qifa Liu

Southern Medical University

Jian Lin

Peking University

Cooperative Institutions

Central South University

190

Second Xiangya Hospital of Central South University

136

Av Engineering (Czechia)

129

Chinese Academy of Sciences

Sun Yat-sen University

Southern Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Zhejiang University

Shanghai Jiao Tong University

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Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes

Diabetes (2014)

Yu Wang Yang Xiao Ling Zhong Dewei Ye Jialiang Zhang

Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D. However, the pathological roles of neutrophils in the development of T1D remain unknown. Here we show that circulating protein levels and enzymatic activities of neutrophil elastase (NE) and proteinase 3 (PR3), both of which are neutrophil serine proteases stored in neutrophil primary granules, were markedly elevated in patients with T1D, especially those with disease duration of less than 1 year. Furthermore, circulating NE and PR3 levels increased progressively with the increase of the positive numbers and titers of the autoantibodies against β-cell antigens. An obvious elevation of NE and PR3 was detected even in those autoantibody-negative patients. Increased NE and PR3 in T1D patients are closely associated with elevated formation of neutrophil extracellular traps. By contrast, the circulating levels of α1-antitrypsin, an endogenous inhibitor of neutrophil serine proteases, are decreased in T1D patients. These findings support an early role of neutrophil activation and augmented neutrophil serine proteases activities in the pathogenesis of β-cell autoimmunity and also suggest that circulating NE and PR3 may serve as sensitive biomarkers for the diagnosis of T1D.

Neutrophil Extracellular Traps

Neutrophil elastase

Proteinase 3

10.2337/db14-0480

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Citations (161)

Decreased serum fibroblast growth factor 19 level is a risk factor for type 1 diabetes

Annals of Translational Medicine (2021)

Jingyi Hu Yingxin Tang Hui Liu Yanhua Li Xia Li

Increasing evidence suggests that fibroblast growth factor 19 (FGF19) is a regulator of glucose metabolism and may provide a new therapeutic target for type 1 diabetes (T1D). However, the clinical relevance of FGF19 in T1D remains unclear. In this study, we examined the relationship between the serum FGF19 concentration and T1D.This study included 81 newly diagnosed T1D patients and 80 sex- and age-matched healthy controls. The correlation between the FGF19 concentration and clinical characteristics of T1D patients and healthy controls was investigated. Logistic regression analysis was performed to determine whether levels of FGF19 were independently associated with T1D.The fasting serum FGF19 levels in the T1D group were significantly lower than those in the control group [159.9 (100.0-272.7) vs. 205.0 (126.9-307.9) pg/mL, P=0.008]. In all subjects, serum FGF19 levels were negatively correlated with fasting blood glucose (FBG) (r=-0.192, P=0.015). In the control group, serum FGF19 levels were positively correlated with total cholesterol (TC) (r=0.338, P=0.002) and low-density lipoprotein cholesterol (LDL-c) (r=0.300, P=0.007). In addition to sex and body mass index (BMI), FGF19 was an independent impact factor for T1D [odds ratio (OR) =0.541, P=0.023; adjusted for sex, age, BMI, presence of hypertension, and presence of dyslipidemia].Low serum FGF19 level is associated with T1D, which could serve as a risk factor for T1D.

FGF19

Dyslipidemia

FGF21

10.21037/atm-20-5203

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Citations (3)

Prior infection of Galleria mellonella with sublethal dose of Bt elicits immune priming responses but incurs metabolic changes

Journal of Insect Physiology (2022)

Gongqing Wu Jia-Jie Liu Mei Li Yang Xiao Yunhong Yi

Priming (agriculture)

Galleria mellonella

10.1016/j.jinsphys.2022.104401

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Citations (17)

Risk of onset of chronic kidney disease in type 2 diabetes mellitus (ROCK-DM): Development and validation of a 4-variable prediction model

Primary care diabetes (2025)

Jie Ming Nigel Fong Serena Low Yang Xiao Edmund Pek Siang Teo Gek Hsiang Lim

10.1016/j.pcd.2025.02.005

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Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes

Clinical Immunology (2023)

Zeying Li Mingjiu Zhao Jingyue Li Wenjun Luo Juan Huang

Insulitis

NOD mice

10.1016/j.clim.2023.109729

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Citations (6)

Abnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients

Journal of Diabetes Research (2020)

Qiuqiu Lin Wenzhi Zhou Yanfei Wang Juan Huang Xiaoyan Hui

Aim . There are increasing evidence demonstrating that neutrophil-mediated inflammation plays a role in the etiology of type 2 diabetes. However, the molecular mechanisms by which neutrophils contribute to type 2 diabetes remain largely unknown. The aim of the present work was to identify possible changes in circulating neutrophils to better elucidate neutrophil involvement in human type 2 diabetes. Methods . Patients newly diagnosed with type 2 diabetes (n=5) and age- and sex-matched healthy controls (n=5) were recruited. Neutrophils were purified from type 2 diabetes patients and controls, and RNA sequencing (RNA-seq) was used for comprehensive transcriptome analysis. Differentially expressed genes (DEGs) were screened, and Gene Ontology (GO) and KEGG pathway enrichment analyses were performed. Real-time polymerase chain reaction (qPCR) was used for validation in external samples of type 2 diabetes patients (n=8) and healthy controls (n=8). Results . Gene expression analysis showed that, compared with neutrophils from healthy controls, there were 1990 upregulated DEGs and 1314 downregulated DEGs in neutrophils from type 2 diabetes patients. GO analysis demonstrated that the DEGs were mainly involved in myeloid leukocyte activation, T cell activation, adaptive immunity, and cytokine production. The top 20 enriched KEGG pathways included the cytokine-cytokine receptor interaction pathway, NF- κ B signaling pathway, cell adhesion molecules, and chemokine signaling pathway. Furthermore, qPCR of genes related to neutrophil activation revealed that the expression of SELL, SELP, CXCR1, and S100A8 was significantly increased in neutrophils from type 2 diabetes patients compared with that in neutrophils from controls. Conclusions . Our study reveals an abnormal activation of circulating neutrophils at the transcriptome level in type 2 diabetes patients. These findings suggest a potential involvement of neutrophil dysfunction in the pathologic process of type 2 diabetes and provide insight into potential therapeutic targets for type 2 diabetes.

10.1155/2020/9519072

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Citations (19)

Avoid six common misunderstandings about medicinal vesiculation

Yang Xiao

Medicinal vesiculation is one of the effective therapies of traditional Chinese medicine. It is widely used in recent years. But many patients and even some health care workers have some misunderstandings about it. Six of the most common misunderstandings are discussed in this article. At the same time, both of the reasons and solutions of those misunderstandings are analyzed here.

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Rat model for morphine dependenc

Journal of North Sichuan Medical College (2001)

Yang Xiao

Objective:To establish the model of morphine dependent rats.Method:Rats were given in gradually increasing doses of morphine to produce physical dependencs.Withdrawal syndrome was precipitated by naloxome.Result:The withdrawal score of morphine group and Nsgraup was 19.63±3.46 and 6.2±1.6.There was significant differnece between the groups(P0.01).Conclusion:The model of morphine dependent rats has been established in treatment of morphin sithdrawal syndrmes.

Rat model

Withdrawal syndrome

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Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway

Journal of Cancer (2021)

Yang Xiao Yijuan Huang Yuanyuan Chen Kun Cao Zhe Liu

Radiation-induced lung injury (RILI) is a common serious complication and dose-limiting factor caused by radiotherapy for lung cancer.This study was to investigate radioprotective effects of grape seed proanthocyanidins (GSP) on normal lung as well as radiosensitizing effects on lung cancer.In vitro, we demonstrated radioprotective effects of GSP on normal alveolar epithelial cells (MLE-12 and BEAS/2B) and radiosensitizing effects on lung cancer cells (LLC and A549).In vivo, we confirmed these two-way effects in tumor-bearing mice.The results showed that GSP inhibited tumor growth, and played a synergistic killing effect with radiotherapy on lung cancer.Meanwhile, GSP reduced radiation damage to normal lung tissues.The two-way effects related to the differential regulation of the MAPK signaling pathway by GSP on normal lung and lung cancer.Moreover, GSP regulated secretion of cytokines IL-6 and IFN-γ and expression of p53 and Ki67 on normal lung and lung cancer.Our findings suggest that GSP is expected to be an ideal radioprotective drug for lung cancer patients who are treated with radiotherapy.

Differential effects

10.7150/jca.49987

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Citations (17)

Haploidentical hematopoietic SCT using helical tomotherapy for total-body irradiation and targeted dose boost in patients with high-risk/refractory acute lymphoblastic leukemia

Bone Marrow Transplantation (2018)

Zujun Jiang Junsong Jia Chunyan Yue Yan Pang Zenghui Liu

Total body irradiation

Tomotherapy

Refractory (planetary science)

Acute lymphocytic leukemia

10.1038/s41409-017-0049-5

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Citations (18)