Abstract We previously reported that rat T‐cell receptor (TCR) Vδ6 of T‐cell hybridomas was preferentially involved in recognition of the cell surface‐expressed 70 kDa rat heat‐shock cognate (hsc70, a constitutively expressed member of the hsp 70 family) protein‐like molecule (#067 molecule). In the present study, we analyzed usage of the TCR Vγ family of #067‐restricted T‐cell hybridomas. Our data indicated that most of these hybridomas expressed transcripts of TCR Vγ1 and/or Vγ2. However, some of the Vγ2 transcripts were out‐of‐frame, suggesting that the TCR Vγ1 family may be important for the recognition of #067‐defined molecules. TCR Vγ1 transcripts were detected in not only #067‐restricted T‐cell hybridomas, but #067‐non restricted ones as well. However, V‐J nucleotide sequences of #067‐restricted and #067‐non restricted T‐cell hybridomas suggested that #067‐restricted T‐cell hybridomas showed limited insertion of nucleotide stretch as compared with #067‐non restricted ones. In terms of amino acids, only one amino acid was added in #067‐restricted T‐cell hybridomas, whereas two or three amino acids were added in #067‐non restricted ones. These data suggest that the heterodimer of the TCR relatively short stretch form of Vγ1 molecule and TCR Vδ6 may participate in recognition of the #067 molecule.
A response surface model has been proposed to evaluate an aerosol release fraction during sodium pool fire in a liquid metal fast reactor (LMFR). Air containing aerosols are radiative and they influence the allocation of combustion heat from the flame to atmospheric gas or sodium pool. Hence, the aerosol release fraction needs to be quantified based on the behavior of the aerosols and physics of mass and heat transfer. However, the aerosol release fraction is one of user-specified parameters of computer codes for the sodium fire safety analysis of the LMFR. In the present study, a response surface model of the aerosol release fraction has been developed based on numerical experiments of aerosol dynamics. For developing the model, aerosol dynamic equation has been solved coupled with thermal-hydraulics and chemical reaction. The authors obtained good agreement of the aerosol release fraction between the numerical experiments and the past experiments. Therefore, the aerosol behavior model has been validated with regard to the pool combustion phenomena and is reasonably applicable to the numerical experiment. Three influential variables on the release fraction are identified as pool temperature, gas temperature and oxygen molar fraction in the air. The proposed response surface model is a quadratic expression of the influential variables and can be easily employed in the sodium fire analysis code.
Abstract Sensitivity studies on Sodium-Water Reaction (SWR), which will take place in a steam generator of Liquid Metal Fast Reactor (LMFR) when a heat transfer tube fails, have been carried out using a multi-dimensional computational code: SERAPHIM. An initial pressure of liquid sodium, an interfacial area density and an evaporation of sodium hydroxide (NaOH) are chosen as a parameter in this study. An influence of the parameter on a development of high temperature zone (>1000°C) and maximum temperature has been investigated from the perspective that one avoids a secondary heat transfer tube failure in a steam generator due to overheating rupture. In the analyses, it is assumed that water vapor leaks into liquid sodium without any barrier for a simplicity. As a result, it is found that the initial pressure and the interfacial area density affect the high temperature zone strongly, whereas they have almost no influence on the maximum temperature in the present configuration. As concerns the evaporation of sodium hydroxide, it influences not on the high temperature zone but on the maximum temperature. The maximum temperature decreases approximately 200°C due to latent heat of the evaporation. It is concluded that the evaporation of sodium hydroxide will be a key phenomenon for maximum temperature investigation in the SWR. KEYWORDS: computer fluid dynamicssodium-water reactionmulti-phase analysissafety analysisliquid metal fast reactor
Abstract A novel modified passive line-bisection test was performed using a computer display with a moving image. In the test, the subjects were required to give verbal responses instead of limb movements. The test, consisting of two subtasks, left-to-right and right-to-left tasks, was applied to patients with unilateral neglect and controls. The patient group showed an obvious mean deviation in both tasks, and showed greater rightward deviation in the right-to-left task than in the left-to-right task. The control group showed little differences between the two tasks. This paper discusses the results obtained from the two different conditions and their correlations. This method provides useful data for the assessment of unilateral neglect. Acknowledgments The authors would like to thank all participants for their valuable contributions. We also would like to thank Dr Naoko Shindo, Dr Hajime Hino and Dr Shinichi Nishio and all attending doctors and medical staff for their help. We also would like to thank the anonymous reviewers for their helpful comments.
