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Chagas Disease

10.1016/j.exppara.2024.108798

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Efeitos da administração de selênio na prenhez de ratas wistar durante a fase aguda da infecção chagásica

Cássia Mariana Bronzon da Costa Carla Domingues dos Santos Sponchiado Vânia Brazão Christian Collins Kuehn Luiz Gustavo Rodrigues Oliveira

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Immunoregulatory actions of melatonin and zinc during chronic Trypanosoma cruzi infection

Journal of Pineal Research (2015)

Vânia Brazão Fabrícia Helena Santello Marina Del Vecchio Filipin Ângela Palamin Azevedo Míriam Paula Alonso Toldo

After one century of the discovery of Chagas' disease and the development of an efficient drug with amplitude of actions both in the acute and chronic phase is still a challenge. Alternative immune modulators have been exhaustively used. For that purpose, melatonin and zinc were administered during chronic Trypanosoma cruzi-infected Wistar rats and several endpoints were assessed. Melatonin has a remarkable functional versatility, being associated with important antioxidant, anti-inflammatory, and anti-apoptotic effects. The cross-talk between zinc and the immune system includes its ability to influence the production and signaling of numerous inflammatory cytokines in a variety of cell types. Our study showed that zinc triggered a decrease in the generation of IFN-γ for TCD4(+) cells. Reduced percentage of CD4(+) T cells producing TNF-α was observed in control melatonin or zinc-and-melatonin-treated animals as compared with untreated rats. On the other hand, a significant increase in the percentage of IL-4 from CD4(+) and CD8(+) T lymphocytes producers was observed 60 days after infection, for all zinc-treated animals, whether infected or not. Melatonin and zinc therapies increased the percentages of CD4(+) and CD8(+) T lymphocytes IL-10 producers. CD4(+) CD25(high) Foxp3(+) T cells were also elevated in zinc- and melatonin-treated animals. The modulation of the immune system influenced by these molecules affected cytokine production and the inflammatory process during chronic T. cruzi infection. Elucidation of the interplay between cytokine balance and the pathogenesis of Chagas' disease is extremely relevant not only for the comprehension of the immune mechanisms and clinical forms but, most importantly, also for the implementation of efficient and adequate therapies.

Pathogenesis

10.1111/jpi.12207

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BIO080 Oral melatonin administration and sexual hormones influences during the experimental chagas’ disease

Revista Eletrônica de Farmácia (2012)

Fabrícia Helena Santello Leony Cristina Caetano Marina Del Vecchio Filipin Vânia Brazão Míriam Paula Alonso Toldo

Chagas’disease is the clinical manifestation of the infection produced by the parasite Trypanosoma cruzi. It’s a zoonosis and the major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Melatonin is an indoleamine synthesized in the pineal gland and its physiological properties are not limited to neuroendocrine system in controlling circadian rhythms, several other actions have been discovered as increase innate and acquired immunity, however, very little is known about its influence on protozoan infections. Gender affects the different steps of an immune response. Exposure to various types of antigens, access to health promotion programs and health care, as well as prioritization of health needs and household resource allocation all affect the different response of females and males to immunologic challenges and it is necessary undertand the influences of immunological mechanisms in health and disease.

Chagas Disease

10.5216/ref.v9i1.21930

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Orchiectomy and melatonin therapy in Trypanosoma cruzi infected rats

Resumos (2010)

Fabrícia Helena Santello Vânia Brazão Marina Del Vecchio Filipin Leony Cristina Caetano Míriam Paula Alonso Toldo

Orchiectomy

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Cytokine modulation, oxidative stress and thymic dysfunctions: Role of age-related changes in the experimental Trypanosoma cruzi infection