Peter J. Giannini

University of Nebraska Medical Center

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Co-Authors

Kishore Shetty

Bombay Hospital

Richard A. Reinhardt

University of Nebraska Medical Center

Nagamani Narayana

Indian Academy of Sciences

Simone Serafini

University of Padua

Kaeli Samson

University of Nebraska Medical Center

Adam L. Reinhardt

Boston Children's Health Physicians

Jeffrey B. Payne

University of Nebraska Medical Center

Alberto Patriti

Ospedali Riuniti Marche Nord

B Tristaino

University of Perugia

N Gullà

Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte

Cooperative Institutions

University of Nebraska Medical Center

Nebraska Medical Center

The Ohio State University

University of Nebraska–Lincoln

University of Notre Dame

Woods Hole Oceanographic Institution

Stonehill College

University of Nebraska at Omaha

Louisiana State University Health Sciences Center New Orleans

Louisiana State University

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Implications of drug dependence on dental patient management.

PubMed (2010)

Eric Y.K. Fung Peter J. Giannini

Drug abuse and dependence/addiction are complex health issues. A broad understanding of these problems is important in terms of dental patient management. Dental professionals should be knowledgeable in recognizing the symptoms of drug abuse and signs of drug-seeking behavior, while ensuring that patients still receive the best possible dental treatment. This article reviews several important characteristics of drug abuse and dependence and provides recommendations for patient management.

Health Professionals

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Citations (10)

Effect of Simvastatin Injections on Temporomandibular Joint Inflammation in Growing Rats

Journal of Oral and Maxillofacial Surgery (2013)

Mark D. George Callista M. Owen Adam L. Reinhardt Peter J. Giannini David B. Marx

10.1016/j.joms.2012.12.020

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Citations (21)

Oral histoplasmosis: An unusual presentation

Head & Neck (2008)

Nagamani Narayana Ryan Gifford Peter J. Giannini John Casey

Histoplasmosis is a localized or systemic fungal infection which may present as an acute primary or "reactivation" infection in the setting of immunosuppression. Tumor necrosis factor alpha (TNF-alpha) antagonists, used in the management of rheumatoid arthritis and Crohn disease, have been linked to reactivation of quiescent histoplasmosis. Microscopically, granulomas are either not evident or are infrequent in histoplasmosis when associated with TNF antagonist therapy presumably due to the suppression of macrophage activity.This article describes an unusual presentation of oral histoplasmosis in a 75-year-old-woman patient on TNF-alpha antagonist, namely infliximab. Microscopically, cellular atypia resulted in a work-up to rule out lymphoma. Gomori's methenamine silver stain demonstrated Histoplasma capsulatum leading to a diagnosis of histoplasmosis. She was treated successfully with itraconozole.This is the first reported case, insofar as the authors are able to determine, of oral histoplasmosis, in a patient undergoing treatment with infliximab.

Histoplasma

Immunosuppression

10.1002/hed.20882

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Citations (18)

Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats

Arthritis Research & Therapy (2015)

Mitchell Knudsen Matthew I. Bury Callie Holwegner Adam L. Reinhardt Yuan Fang

Histology

10.1186/s13075-015-0772-5

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Citations (12)

A hybrid giant cell granuloma and fibro-osseous lesion of the mandible

Oral Oncology Extra (2004)

Kishore Shetty Peter J. Giannini Janet E. Leigh

Mandible (arthropod mouthpart)

Central giant-cell granuloma

10.1016/j.ooe.2004.05.001

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Citations (8)

Functional Activities and Immunohistochemical Cellular Distribution of Glutathione S-Transferases in Normal, Dysplastic, and Squamous Cell Carcinoma Human Oral Tissues

Clinical medicine Oncology (2008)

Peter J. Giannini Mark A. Morse Christopher M. Weghorst Ping Pei Susan R. Mallery

Clinical data show a strong correlation between tobacco and alcohol use and the development of oral squamous cell carcinoma (SCC). While this association implies that the oral mucosa actively metabolizes carcinogens, there is little information which depicts the carcinogen metabolizing enzymes within the oral cavity. Glutathione S-transferases (GSTs) primary function is to detoxify carcinogens by increasing their water solubility, GSTs represent key carcinogen metabolizing enzymes. Notably, individuals with a null phenotype for certain GST isoforms are at an increased risk to develop cancer. This study investigated the function and distribution of GSTs in human oral tissues. Our results from this pilot study showed a trend towards higher GST activities in SCC tissues relative to normal mucosa. Also, relative to normal tissues, the SCC and epithelial dysplasia samples showed a more intense and uniform GST intracellular distribution. GST activities are increased in many high grade cancers. Similarly, our data suggest that GST upregulation occurs in at least a subset of precancerous and malignant oral lesions.

Oral mucosa

Glutathione S-transferase

Epithelial dysplasia

10.4137/cmo.s491

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Citations (12)

[Clinico-statistical study of fractures caused by shock therapy].

PubMed (1954)

Lasagni Mp Peter J. Giannini

Shock therapy

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Permanent incisors traumatized through predecessors: sequelae and possible management.

PubMed (2003)

Mohamed Bassiouny Peter J. Giannini Lisa P Deem

This report describes the sequence of events following a traumatic dental injury to primary maxillary anterior teeth of a five-year old male during a bicycle accident. The development of the affected teeth during the subsequent ten years was studied from the radiographic records. A detailed account of the clinical and radiographic findings as well as the physio-pathologic changes that have taken place is discussed. In view of the inevitable prognosis of dentitions that sustain traumatic injury during the formative years preventive measures and feasible dental management are proposed. These precautionary measures are aimed to circumvent the sequelae that were experienced in the present case, and avoid predictable complications.

Dental trauma

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Citations (20)

Malignant PEComa involving the mandible: report of a unique case

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology (2012)

Jason Untrauer Peter J. Giannini Geoffrey A. Talmon Sonny L. Johansson

Mandible (arthropod mouthpart)

10.1016/j.oooo.2012.03.018

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Citations (7)

Kaposi’s sarcoma of lymph node leading to a diagnosis of HIV