In the human embryo of 6–8 somites, the primitive gut is closed at the cranial end by the pharyngeal membrane which forms the floor of an external depression, the stomadeum. At this site, ectoderm and entoderm come into direct contact. When the embryo is about 2.5 mm long (18–20 somites), the pharyngeal membrane ruptures and the stomadeum develops into the ectodermal portions of the mouth. At this stage, the stomadeal epithelium situated dorsally and just in front of the remnants of the pharyngeal membrane evaginates to form the Rathke's pouch, i.e., the anlage of the adenohypophysis. This outpocketing enlarges quickly towards the floor of the diencephalon. Its originally wide mouth soon becomes compressed by a proliferation of the surrounding mesenchyme. Thus, the anlage of the adenohypophysis becomes an epithelial vesicle which remains temporarily connected to the roof of the primitive oral cavity by a slender epithelial stalk.KeywordsGrowth HormonePituitary AdenomaGrowth Hormone DeficiencyGrowth Hormone SecretionHuman Growth HormoneThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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