Pavlov Ka

Federal Medical Research Centre for Psychiatry and Narcology

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ЕА

Е. А. Дубова

State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan

ОИ

О. И. Гурина

Federal Medical Research Centre for Psychiatry and Narcology

ВП

В. П. Чехонин

Endocrinology Research Center

Yana Zorkina

Federal Medical Research Centre for Psychiatry and Narcology

Olga Abramova

Federal Medical Research Centre for Psychiatry and Narcology

АM

Аnna Morozova

Moscow Research and Clinical Center for Neuropsychiatry

Olga Pavlova

Ministry of Health of the Russian Federation

Valeria Ushakova

Federal Medical Research Centre for Psychiatry and Narcology

Shchegolev Ai

G. P. Kostyuk

Moscow Regional Psychiatry Hospital No.5

Cooperative Institutions

Ministry of Health of the Russian Federation

Federal Medical Research Centre for Psychiatry and Narcology

Federal Medical-Biological Agency

State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan

Pirogov Russian National Research Medical University

Moscow Research and Clinical Center for Neuropsychiatry

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Russian Academy of Sciences

Sechenov University

Lomonosov Moscow State University

Author Statistics

Papers

Citation

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[The results of a dispensary follow-up after endoscopic electroexcision of colonic polyps].

PubMed (1983)

Pavlov Ka Volkov Dp Sherbakov Am

With the help of fibrocolonoscopy 200 electroexcisions of epithelial polyps of the colon were performed in 116 patients. Control endoscopic examinations revealed 24 cases (12,0%) of recurrent polyps in the zone of their excision. A rational method of the dispensary follow-up of the patients after electrosurgical polypectomy during fibrocolonoscopy was elaborated on the bases of studying some factors influencing substantially the prognosis of the disease.

Dispensary

Polypectomy

Adenomatous polyps

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Clinical and morphological characteristics of type 1 and 2 autoimmune pancreatitis

Almanac of Clinical Medicine (2018)

С. В. Лищук Е. А. Дубова Pavlov Ka Yu. D. Udalov

Rationale: In the recent years, an increased interest to autoimmune pancreatitis (AIP) has been seen, related to growing diagnostic potential. In its turn, this leads to an increase in numbers of diagnosed AIP cases. At present, two types of AIP have been described with diverse clinical manifestation and morphology of the pancreas. However, the reproducibility of the differential diagnosis between AIP type 1 and 2 is low even among pancreatic pathologists. Aim: To identify criteria for the morphologic diagnosis of AIP type 1 and 2. Materials and methods: A morphological study of biopsy and surgical specimens from 26 patients with AIP was performed. There were 22 cases of AIP type 1 and 4 cases of AIP type 2. In addition to hematoxylin eosin staining of the specimens, immunohistochemistry was used with counting of CD138+ absolute numbers, determination of IgG+ and IgG4+ cells in the inflammatory infiltrates, as well as the ratios of IgG4+/IgG+ and IgG4+/CD138+ cells. Results: AIP type 1 was characterized by storiform fibrosis of the pancreatic tissue (81.8% cases), involving the parapancreatic fat tissue, by moderateto-severe lymphoplasmocytic infiltration and signs of obliterative/non-obliterative phlebitis. Type 2 AIP was characterized by severe fibrosis with predominantly periductal (centrilobular) fibrosis and mild chronic inflammatory infiltration of the pancreas, while there was no extension of fibrosis and inflammatory infiltration to the parapancreatic tissues in any case. The mean number of CD138+ cell in AIP type 1 was 101.2 ± 27.9 per 1 high-power field (HPF), and in AIP type 2, it was 42.8 ± 20.9 per 1 HPF. The mean absolute number of IgG+ cells in AIP type 1 was 99.6 ± 25.7 per 1 HPF, whereas in AIP type 2, 42.1 ± 20.8 per 1 HPF. In AIP type 1, the mean number of IgG4+ plasmatic cells in the infiltrates was 74.5 ± 27.2 per 1 HPF, whereas in AIP type 2, it was 3.4 ± 2.7 per 1 HPF. The IgG4+/IgG+ ratio was 75 ± 12.6% vs. 8.4 ± 6.2%, and the IgG4+/CD138+ ratio was 72.4 ± 12.3% vs. 8.3 ± 5.9% in AIP type 1 and type 2, respectively. Conclusion: For the differential diagnosis of type 1 and 2 AIP, it is necessary to take into consideration not only typical histological abnormalities, but also the numbers of CD138+, IgG+ and IgG4+ cells within the inflammatory infiltrate, as well as the IgG4+/IgG+ and IgG4+/CD138+ ratios.

Autoimmune Pancreatitis

Infiltration (HVAC)

High-power field

Pancreatic Disease

IgG4-Related Disease

10.18786/2072-0505-2018-46-4-330-337

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Citations (0)

Activation of Expression of Brain-Derived Neurotrophic Factor at the Site of Implantation of Allogenic and Xenogenic Neural Stem (Progenitor) Cells in Rats with Ischemic Cortical Stroke

Bulletin of Experimental Biology and Medicine (2011)

В. П. Чехонин С. В. Лебедев A. I. Volkov Pavlov Ka A. A. Ter-Arutyunyants

10.1007/s10517-011-1180-8

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Citations (8)

Genes (2022)

Olga Abramova Kristina Soloveva Yana Zorkina Dmitry Gryadunov A. Yu. Ikonnikova

Dementia has enormous implications for patients and the health care system. Genetic markers are promising for detecting the risk of cognitive impairment. We hypothesized that genetic variants associated with suicide risk might significantly increase the risk of cognitive decline because suicide in older adults is often a consequence of cognitive impairment. We investigated several single-nucleotide polymorphisms that were initially associated with suicide risk in dementia older adults and identified the APOE gene alleles. The study was performed with subjects over the age of 65: 112 patients with dementia and 146 healthy volunteers. The MMSE score was used to assess cognitive functions. Study participants were genotyped using real-time PCR (APOE: rs429358, rs7412; genes associated with suicide: rs9475195, rs7982251, rs2834789, rs358592, rs4918918, rs3781878, rs10903034, rs165774, rs16841143, rs11833579 rs10898553, rs7296262, rs3806263, and rs2462021). Genotype analysis revealed the significance of APOEε4, APOEε2, and rs4918918 (SORBS1) when comparing dementia and healthy control groups. The association of APOEε4, APOEε2, and rs10903034 (IFNLR1) with the overall MMSE score was indicated. The study found an association with dementia of rs4918918 (SORBS1) and rs10903034 (IFNLR1) previously associated with suicide and confirmed the association of APOEε4 and APOEε2 with dementia.

Apolipoprotein E

Cognitive Decline

10.3390/genes13112174

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Citations (2)

The Role of BDNF in the Antidepressant Effects of Electroconvulsive Therapy

Doklady Biological Sciences (2024)

Valeria Ushakova Eugene Zubkov Аnna Morozova Pavlov Ka Yana Zorkina

10.1134/s0012496624600313

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NMDA receptors, anti-nmda receptor antibodies and their role in psychiatric and neuroinflammatory disorders

Molekulyarnaya Meditsina (Molecular medicine) (2021)

Olga Pavlova Pavlov Ka A. A. Murashko О. И. Гурина А.Б. Шмуклер

10.29296/24999490-2021-01-01

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Citations (2)

[Organization of mass examinations of women for the purpose of diagnosing early forms of breast diseases].

PubMed (1979)

Pavlov Ka Mishura Vi Karachunskiĭ Ms Nazarenko Vp

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Vascular Endothelial Growth Factor and Its Receptors in the Placental Villi of Pregnant Patients with Pre-Eclampsia

Bulletin of Experimental Biology and Medicine (2013)

Е. А. Дубова Pavlov Ka V. M. Lyapin A. I. Shchyogolev Г. Т. Сухих

10.1007/s10517-013-2058-8

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Citations (13)

Association of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A With Clinical Features of Youth-Onset Schizophrenia

Frontiers in Psychiatry (2019)

Аnna Morozova Yana Zorkina Pavlov Ka Olga Pavlova З. И. Сторожева

We investigated the associations of rs4680 COMT, rs6280 DRD3 and rs7322347 5HT2A with youth-onset schizophrenia in the Russian population in a case-control study, and the role of the genotype in the severity of clinical features. The association between rs7322347 and schizophrenia (p = 0.0001) is described for the first time. Furthermore, we found a link with rs6280 and rs4680 in females (p = 0.001 and p = 0.02 respectively) and with rs7322347 in males (p = 0.002). Clinical symptoms were assessed on three scales: the Clinician-Rated Dimensions of Psychosis Symptom Severity scale, PANSS and FAB. Gender differences in clinical features are of particular interest. In our study we found gender differences in the severity of clinical features - higher scores for delusions (PANSS and DSM-V) in males and higher scores for depression, delusions, somatic concern, motor retardation, poor attention were found in females.

rs4680

Association (psychology)

Depression

10.3389/fpsyt.2019.00830

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Citations (17)

BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia

Genes (2024)

Аnna Morozova Valeria Ushakova Olga Pavlova Sakeena Bairamova Nika Andryshenko

The prevalence of mental disorders and how they are diagnosed represent some of the major problems in psychiatry. Modern genetic tools offer the potential to reduce the complications concerning diagnosis. However, the vast genetic diversity in the world population requires a closer investigation of any selected populations. In the current research, four polymorphisms, namely rs6265 in BDNF, rs10835210 in BDNF, rs6313 in HTR2A, and rs1800955 in DRD4, were analyzed in a case–control study of 2393 individuals (1639 patients with mental disorders (F20-F29, F30-F48) and 754 controls) from the European part of Russia using the TaqMan SNP genotyping method. Significant associations between rs6265 BDNF and rs1800955 DRD4 and mental impairments were detected when comparing the general group of patients with mental disorders (without separation into diagnoses) to the control group. Associations of rs6265 in BDNF, rs1800955 in DRD4, and rs6313 in HTR2A with schizophrenia in patients from the schizophrenia group separately compared to the control group were also found. The obtained results can extend the concept of a genetic basis for mental disorders in the Russian population and provide a basis for the future improvement in psychiatric diagnostics.

rs6265

10.3390/genes15020240

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