Franklin F. F. Nóbrega

Centro de Tecnologias Estratégicas do Nordeste

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Damião Pergentino de Sousa

Universidade Federal da Paraíba

Reinaldo Nóbrega de Almeida

Universidade Federal da Paraíba

Timothy J. Brocksom

Universidade Federal de São Carlos

Camila C. Santos

Fundação Oswaldo Cruz

Carlos Fernando Mello

Universidade Federal de Santa Maria

José Roberto Leite

Universidade de São Paulo

C Masson

Hospices Civils de Lyon

Rubens Batista Benedito

Universidade Federal da Paraíba

Rita Mattei

Universidade Federal de São Paulo

Tiago S. Nascimento

Universidade Tiradentes

Cooperative Institutions

Universidade Federal da Paraíba

Universidade Federal de Santa Maria

Universidade de São Paulo

Universidade Federal de São Paulo

Universidade Federal de Sergipe

Universidade Federal de São Carlos

Associação Paulista de Medicina

Universidade Federal de Campina Grande

Universidade Federal do Piauí

Universidade Federal do Ceará

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Evaluation of the Anticonvulsant Activity of Terpinen-4-ol

Zeitschrift für Naturforschung C (2009)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Liana Clébia Soares Lima de Morais Reinaldo Nóbrega de Almeida

Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol ( 200 mg/kg) caused a signifi cant decrease in the spontaneous motor activity at 30, 60 and 120 min after administration. Terpinen-4-ol (100 and 200 mg/kg) produced a significant dosedependent increase in the duration of sleeping in mice. Pretreatment of mice with terpinen-4- ol at doses of 100, 200 and 300 mg/kg significantly increased the latency of pentylenetetrazole -induced convulsions. Terpinen-4-ol (200 and 300 mg/kg) also inhibited the induced seizures of picrotoxin. In another model, maximal electroshock seizure, terpinen-4-ol decreased the tonic hind convulsions percentage at the dose of 300 mg/kg. From the overall results we can conclude that terpinen-4-ol showed a depressant effect on the central nervous system and significant anticonvulsant activity.

Picrotoxin

Convulsion

10.1515/znc-2009-1-201

Cite

Citations (38)

Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies

Oxidative Medicine and Cellular Longevity (2014)

Franklin F. F. Nóbrega Mirian Graciela da Silva Stiebbe Salvadori C Masson Carlos Fernando Mello Tiago S. Nascimento

Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μ L. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of theGABAAreceptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.

Flumazenil

Pentylenetetrazol

10.1155/2014/703848

Cite

Citations (37)

Anticonvulsant Activity of the Linalool Enantiomers and Racemate: Investigation of Chiral Influence

Natural Product Communications (2010)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Camila C. Santos Reinaldo Nóbrega de Almeida

The anticonvulsant activity of the racemate and enantiomers of linalool have been evaluated. Pretreatment of the mice with (S)-(+)-, (R)-(-)- and rac-linalool increased the latency of convulsions significantly in the PTZ model. Only rac-linalool had an effect at the dose of 200 mg/kg. The enantiomers and their racemic mixture were effective in inhibiting the convulsant effect of PTZ at the dose of 300 mg/kg. The linalools presented pharmacological activity close to that of diazepam. In the PIC seizure model, (R)-(-)-linalool and rac-linalool presented activity at the dose of 200 mg/kg, but the rac-linalool was more potent than (R)-(-)-linalool; (S)-(+)-linalool had no effect at this dose. On the other hand, at the dose of 300 mg/kg this enantiomer was effective, but less potent than (R)-(-)-linalool and rac-linalool. In the MES model, linalools decreased the convulsion time of the mice in the doses of 200 and 300 mg/kg. rac-Linalool presented maximum effect at 300 mg/kg. Surprisingly, it increased significantly the convulsion time at a dose of 100 mg/kg. Using the parameter of tonic hind convulsions, only (R)-(-)-linalool produced protection from tonic extension at the dose of 200 mg/kg. When the (+)- and (-)-enantiomers, and rac-linalool were administered at the dose of 300 mg/kg they were also effective in preventing tonic convulsions induced by transcorneal electroshock in the animals. The (+)- and (-)-forms were equipotent and the rac-linalool was more effective than phenytoin. We have demonstrated that the two enantiomers have similar qualitative anticonvulsant activity, but show different potencies.

Convulsion

Monoterpene

Convulsants

10.1177/1934578x1000501201

Cite

Citations (67)

Pharmacological effects of the monoterpene alpha,beta-epoxy-carvone in mice

Revista Brasileira de Farmacognosia (2007)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Fladmir S. Claudino Reinaldo Nóbrega de Almeida José Roberto Leite

The monoterpene alpha,beta-epoxy-carvone (EC) in doses of 200, 300 or 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 120 minutes after the administration. The doses of 300 or 400 mg/kg had induced a significant increase of in the sleeping time of animals not having modified, however, the latency. The EC in the dose of 400 mg/kg reduced the remaining time of the animals on the rotating rod (Rotarod test). These results suggest a possible central effect.

Monoterpene

Carvone

Alpha (finance)

BETA (programming language)

10.1590/s0102-695x2007000200006

Cite

Citations (40)

Pharmacological Activity of (R)-(+)-Pulegone, a Chemical Constituent of Essential Oils

Zeitschrift für Naturforschung C (2011)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Maria Raquel Vitorino de Lima Reinaldo Nóbrega de Almeida

(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a significant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also significantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.

Pulegone

Menthone

Monoterpene

10.1515/znc-2011-7-806

Cite

Citations (52)

ChemInform Abstract: Synthesis and Analgesic‐Like Effect of (6R,4S)‐p‐Mentha‐1,8‐dien‐6‐yl‐methylene‐p‐toluenesulfonamide.

ChemInform (2009)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Reinaldo Nóbrega de Almeida Timothy J. Brocksom

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Methylene

10.1002/chin.200930195

Cite

Citations (0)

Synthesis and Analgesic-like Effect of (6R, 4S)-p-Mentha-1,8-dien-6-ylmethylene- p-toluenesulfonamide

Zeitschrift für Naturforschung B (2009)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Reinaldo Nóbrega de Almeida Timothy J. Brocksom

The synthesis of a monoterpene-based para-toluenesulfonamide is reported starting from naturally occurring (R)- (−)-carvone (1), by 1,2-addition of HCN followed by reduction with lithium aluminum hydride to afford the amino alcohols 3a and 3b. Tosylation of thismixture with p-toluenesulfonyl chloride furnished sulfonamide 4 in 55% overall yield. Compound 4 was evaluated in behavior animal models to investigate its effects on the central nervous system. It showed low toxicity and sedative action in mice, indicating it to be psychoactive. It also caused a decrease in the spontaneous motor activity of mice. This depressant effect was confirmed in the acetic acid-induced writhing test, which demonstrated a significant antinociceptive response more potent than 1. The present results provide evidence that sulfonamide 4 has analgesic-like psychopharmacological activity.

Sulfonamide

ALUMINUM HYDRIDE

Depressant

10.1515/znb-2009-0319

Cite

Citations (2)

Anticonvulsant activity of thymoquinone and its structural analogues

Revista Brasileira de Farmacognosia (2011)

Damião Pergentino de Sousa Franklin F. F. Nóbrega Camila C. Santos Rubens Batista Benedito Ygor W. Vieira

It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds.

Thymoquinone

Ranunculaceae

Nigella sativa

10.1590/s0102-695x2011005000040

Cite

Citations (12)