Sabrina Williams

HOPE Clinic

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Rosemary Hollick

Johns Hopkins University

Jennifer Milucky

Centers for Disease Control and Prevention

Fabiana Cristina Pimenta

Centers for Disease Control and Prevention

Monica M. Farley

Emory University

Amy Tunali

Brookhaven College

Stephanie Thomas

Cincinnati Children's Hospital Medical Center

Nadine Rouphael

HOPE Clinic

Jeremy Walston

Johns Hopkins Medicine

H. Keipp Talbot

Vanderbilt University Medical Center

Lee H. Harrison

University of Pittsburgh

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Emory University

Johns Hopkins University

Centers for Disease Control and Prevention

National Center for Immunization and Respiratory Diseases

Veterans Health Administration

HOPE Clinic

Johns Hopkins Medicine

Georgia Department of Public Health

New Mexico Department of Health

Atlanta VA Medical Center

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Streptococcus pneumoniae colonization after introduction of 13-valent pneumococcal conjugate vaccine for US adults 65 years of age and older, 2015–2016

Vaccine (2019)

Jennifer Milucky Maria de Gloria Carvalho Nadine Rouphael Nancy M. Bennett H. Keipp Talbot

Vaccination of children with 13-valent pneumococcal conjugate vaccine (PCV13) led to declines in vaccine-type pneumococcal nasopharyngeal carriage among adults through indirect effects. In August 2014, PCV13 immunization of all U.S. adults ≥65 years of age was recommended. This study sought to define prevalence and serotype distribution of pneumococcal carriage among adults ≥65 years of age and to describe risk factors for colonization soon after introduction of PCV13 in adults.

Carriage

Pneumococcal Conjugate Vaccine

Pneumococcal infections

10.1016/j.vaccine.2018.12.075

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Citations (26)

Survival of Streptococcus pneumoniae in sputum from patients with pneumonia

Journal of Clinical Microbiology (1978)

Sabrina Williams Carol A. Kauffman

The isolation rate of Streptococcus pneumoniae in sputum cultures from patients with pneumococcal pneumonia is low. An investigation was made to determine whether this low yield might be due to loss of pneumocci and/or overgrowth by pharyngeal flora before the specimen is plated. Pneumococcal survival times and pharyngeal overgrowth at 4 degrees C and at room temperature were determined in sputum obtained from 42 patients with pneumococcal pneumonia. It was found that pneumococci survived for long periods in sputum--2.2 +/- 1.4 days at room temperature and 9.5 +/- 3.6 days at 4 degrees C. Overgrowth by pharyngeal flora occurred in only 6 of 42 specimens kept at 4 degrees C and 31 of 42 specimens kept at room temperature. The low yield of S. pneumoniae in sputum from patients with pneumococcal pneumonia is not explained by decreased viability of the organism.

Pneumococcal pneumonia

Pneumococcal infections

10.1128/jcm.7.1.3-5.1978

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Citations (15)