Marcus Lira Brandão

Universidade de São Paulo

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Milene Cristina de Carvalho

Universidade de São Paulo

Amanda Ribeiro de Oliveira

Universidade Federal de Minas Gerais

Norberto Cysne Coimbra

Universidade de São Paulo

Manoel Jorge Nobre

Universidade de Ribeirão Preto

Karina Genaro Borelli

Instituto de Neurociências e Comportamento

Adriano E. Reimer

University of Minnesota

V.M. Castilho

Universidade de Ribeirão Preto

Lucas Albrechet‐Souza

Louisiana State University Health Sciences Center New Orleans

Carlos Eduardo Macedo

Escola Bahiana de Medicina e Saúde Pública

Frederico Guilherme Graeff

Universidade de São Paulo

Cooperative Institutions

Universidade de São Paulo

198

Universidade de Ribeirão Preto

101

Instituto de Neurociências e Comportamento

Clinics Hospital of Ribeirão Preto

Universidade Brasil

Heinrich Heine University Düsseldorf

Universidade Federal do Paraná

Universidade Federal de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

National Council for Scientific and Technological Development

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Concentrações plasmáticas de corticosterone em ratos Carioca Alto- e Carioca Bajo-Congelamento condicionado após uma tarefa de medo condicionado

Laura León Vitor Castro Gomes Marcus Lira Brandão Celso Rodrigues Fernando P. Cárdenas

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Effects of inactivation of serotonergic neurons of the median raphe nucleus on learning and performance of contextual fear conditioning

Neuroscience Letters (2005)

Karina Genaro Borelli Ana Carolina Gárgaro Júlia Maria dos Santos Marcus Lira Brandão

Median raphe nucleus

Freezing behavior

Raphe nuclei

Microdialysis

Raphe

Neurochemical

10.1016/j.neulet.2005.07.031

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Citations (42)

Facilitation of 5-HT1A-mediated neurotransmission in dorsal periaqueductal grey matter accounts for the panicolytic-like effect of chronic fluoxetine

The International Journal of Neuropsychopharmacology (2009)

Janaína Menezes Zanoveli Roger L.H. Pobbe Valquiria C. de Bortoli Milene Cristina de Carvalho Marcus Lira Brandão

Chronic administration of antidepressants such as fluoxetine and imipramine increases the responsiveness of 5-HT(1A) receptors in dorsal periaqueductal grey matter (DPAG), a midbrain area consistently implicated in the pathogenesis of panic disorder. This effect has been related to the clinically relevant anti-panic action of these drugs. In this study we determined whether long-term administration of fluoxetine also affects 5-HT efflux in DPAG. As a comparison, the effect of chronic treatment with the anxiolytic 5-HT(1A) receptor agonist buspirone on DPAG 5-HT levels was assessed. We also investigated whether the inhibitory effect of chronic fluoxetine on escape behaviour in the rat elevated T-maze, considered as a panicolytic-like effect, is counteracted by intra-DPAG injection of the 5-HT(1A) receptor antagonist WAY 100635. Male Wistar rats were treated (1 or 21 d, i.p.) with fluoxetine, buspirone or vehicle, once daily. After treatment, 5-HT in DPAG was measured by in-vivo microdialysis coupled to HPLC. In another study, rats treated (21 d, i.p.) with either fluoxetine or vehicle also received intra-DPAG injection of WAY 100635 or saline 10 min before being tested in the elevated T-maze. Chronic, but not acute, administration of fluoxetine significantly raised extracellular levels of 5-HT in DPAG. Long-term treatment with buspirone was ineffective. In the elevated T-maze, intra-DPAG injection of WAY 100635 fully blocked the anti-escape effect of chronic administration of fluoxetine. Therefore, chronic fluoxetine facilitates 5-HT(1A)-mediated neurotransmission within DPAG and this effect accounts for the panicolytic-like effect of this antidepressant in the elevated T-maze.

10.1017/s146114570999099x

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Citations (54)

Dopaminergic mechanisms underlying catalepsy, fear and anxiety: Do they interact?

Behavioural Brain Research (2013)

Ana Caroline Colombo Amanda Ribeiro de Oliveira Adriano E. Reimer Marcus Lira Brandão

Catalepsy

10.1016/j.bbr.2013.10.002

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Citations (22)

Neural substrate of defensive behavior in the midbrain tectum

Neuroscience & Biobehavioral Reviews (1994)

Marcus Lira Brandão Sílvia Helena Cardoso Lauro Melo V. Motta Norberto Cysne Coimbra

Superior colliculus

Periaqueductal gray

Tectum

Neural substrate

Escape response

Electrical brain stimulation

Tegmentum

10.1016/0149-7634(94)90047-7

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Citations (180)

Padrões de respostas defensivas de congelamento associados a diferentes transtornos de ansiedade

Psicologia USP (2006)

J. Landeira‐Fernandez Antônio Pedro de Mello Cruz Marcus Lira Brandão

Embora os transtornos de ansiedade sejam tipicamente humanos, eles apresentam correlações com determinadas reações de defesa de animais em situações de perigo. Este trabalho apresenta algumas relações entre determinados padrões da resposta defensiva de congelamento e diferentes formas de transtornos de ansiedade. Em particular, destaca-se o isomorfismo entre a resposta de congelamento a estímulos contextuais associados a um estímulo aversivo e o transtorno de ansiedade generalizado. Evidências indicam também que a resposta de congelamento induzida pela estimulação elétrica da matéria cinzenta periaqueductal dorsal (MCPD) constitui um excelente modelo animal de ataque de pânico. A resposta de congelamento que surge imediatamente após estimulação da MCPD, capaz de produzir uma resposta de fuga, parece estar associada ao transtorno de pânico. Finalmente, é possível que a resposta de congelamento a estímulos previamente associados à estimulação elétrica da MCPD seja um modelo animal para o transtorno de pânico com agorafobia.

10.1590/s0103-65642006000400010

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Citations (4)

Effect of steroid injection to newborn rats on serotonin activity in frontal cortex and raphe

Neuroreport (2003)

Roberto Domı́nguez Sara E. Cruz-Morales Milene Cristina de Carvalho Maristela Xavier Marcus Lira Brandão

The effects of injecting testosterone propionate or estradiol benzoate to newborn rats on dopaminergic and serotoninergic activity in the frontal cortex, dorsal and median raphe nucleus were analyzed when animals reached adulthood. High performance liquid chromatography was used to measure tissue levels of dopamine, serotonin and its metabolites. Activity was calculated as the metabolite/neurotransmitter ratio. An increase in androgen or estrogen levels at birth caused a significant decrease in serotoninergic activity in the frontal cortex and in the dorsal raphe nucleus, without causing apparent changes in dopaminergic activity; serotinergic activity in the median raphe nucleus was not affected. The results suggest that the transmission of DA and 5-HT in these structures are differentially influenced by early androgenization or estrogenization.

Dorsal raphe nucleus

Median raphe nucleus

Raphe nuclei

Raphe

10.1097/00001756-200303240-00014

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Citations (21)

Effects of neurokinin-1 and 3-receptor antagonists on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray

Neuroscience (2011)

Ana Carolina Garcia Broiz Gabriel Shimizu Bassi M.A. De Souza Silva Marcus Lira Brandão

Periaqueductal gray

Neurokinin A