Xiaoqin Tan

Guangzhou University of Chinese Medicine

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Qian Tang

Sichuan Agricultural University

Qing X. Li

Louisiana State University Agricultural Center

Lang Yi

Guangzhou University of Chinese Medicine

Liqiang Tan

Science and Technology Department of Sichuan Province

Wenmin Yang

Institut Néel

Chi Liu

Yale University

Xiaoliang Liu

Army Medical University

Jiangping Zhang

Minzu University of China

Shuyi Liao

Army Medical University

Jinghong Zhao

Xinqiao Hospital

Cooperative Institutions

Sichuan Agricultural University

Guangzhou University of Chinese Medicine

Army Medical University

Xinqiao Hospital

Chinese Academy of Sciences

Science and Technology Department of Sichuan Province

Huazhong University of Science and Technology

University of Chinese Academy of Sciences

Peking University

Shanghai Jiao Tong University

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Evaluation of sensory and safety quality characteristics of “high mountain tea”

Food Science & Nutrition (2022)

Cong‐ming Wang Xiao Du Cong‐ning Nie Xiang Zhang Xiaoqin Tan

Abstract High mountain tea (HT) is widely acknowledged as an essential resource of high‐quality tea due to its adaptation to superior ecological environments. In this study, the sensory (aroma and taste) and safety (heavy metals and pesticide residues) characteristics of HT were characterized through sensory evaluation, gas chromatography–mass spectrometry (GC‐MS), liquid chromatography–mass spectrometry (LC‐MS), flavor activity value, and risk factor analysis. The results elucidated that the aroma sensory characteristics of HT were tender and green, accompanied by sweet and slight chestnut. A total of 8 aroma compounds were identified as the primary substances contributing to the unique aroma characteristics; the difference in the ratio of "green substances" and "chestnut substances" might be the reason for different aroma characteristics in HT and LT (low mountain tea). The taste sensory characteristics of HT were high in freshness and sweetness but low in bitterness and astringency. The high content of soluble sugar (SS), nonester catechins, sweet free amino acids, and low content of caffeine and tea polyphenols were the primary reasons for its taste characteristics. Low temperature stress might be the most fundamental reason for flavor characteristics formation in HT. Furthermore, the pollution risks of 5 heavy metals and 50 pesticide residues in HT were less than 1. The complex ecosystem and low chemical control level were speculated to be the primary reasons for the high safety quality of HT. Overall, these findings provide a more comprehensive understanding of quality characteristics and their formation mechanisms in HT.

Sweetness

Flavour

10.1002/fsn3.2923

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Citations (15)

Author response: Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2

Xiaoliang Liu Ting Yu Xiaoqin Tan Daqing Jin Wenmin Yang

10.7554/elife.81438.sa2

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Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor

Journal of Leukocyte Biology (2020)

Shasha Bai Wenhao Wen Xuenan Hou Jiexiu Wu Lang Yi

Abstract Lung cancer is the leading cause of cancer deaths worldwide, with a high morbidity and less than 20% survival rate. Therefore, new treatment strategies and drugs are needed to reduce the mortality of patients with lung cancer. α7 nicotinic acetylcholine receptor (α7 nAChR), as a receptor of nicotine and its metabolites, is a potential target for lung cancer treatment. Our previous studies revealed that sinomenine plays anti-inflammation roles via α7 nAChR and down-regulates the expression of this receptor, thus increasing the inflammatory response. Hence, sinomenine is possibly a natural ligand of this receptor. In the present study, the effects of sinomenine on lung cancer A549 cells and tumor-bearing mice were determined to investigate whether this alkaloid has an inhibitory effect on lung cancer via α7 nAChR. CCK-8 assay, wound-healing test, and flow cytometry were performed for cell proliferation, cell migration, and apoptosis analysis in vitro, respectively. Xenograft mice were used to evaluate the effects of sinomenine in vivo. Results showed that sinomenine decreased cell proliferation and migration abilities but increased the percentage of apoptotic cells. Tumor volume in tumor-bearing mice was significantly reduced after sinomenine treatment compared with that in the vehicle group mice (p < 0.05). Furthermore, the effects of sinomenine were abolished by the α7 nAChR antagonist mecamylamine and the allosteric modulator PNU-120596, but no change occurred when the mice were pretreated with the muscarinic acetylcholine receptor antagonist atropine. Meanwhile, sinomenine suppressed α7 nAChR expression in vitro and in vivo, as well as the related signaling molecules pERK1/2 and ERK1/2 and the transcription factors TTF-1 and SP-1. By contrast, sinomenine up-regulated the expression of another transcription factor, Egr-1. These effects were restricted by mecamylamine and PNU but not by atropine. Results suggested that sinomenine can inhibit lung cancer via α7 nAChR in a negative feedback mode.

Sinomenine

Methyllycaconitine

10.1002/jlb.6ma0720-344rrr

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The removal of flower buds improves the yield and quality of tea shoots by mediating carbon and nitrogen metabolism in the source leaves

Scientia Horticulturae (2023)

Xiaoqin Tan Hui Li Cong‐ming Wang Dandan Tang Wei Chen

WRKY protein domain

Carbohydrate Metabolism

10.1016/j.scienta.2023.112735

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Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration

Nature Communications (2023)

Chi Liu Xiaoliang Liu Zhongwei He Jiangping Zhang Xiaoqin Tan

Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the mechanisms underlying this intricate molecular crosstalk remain elusive. In this study, the level of proenkephalin-A (PENK-A), expressed by renal proximal tubular epithelial cells, decreases significantly with the loss of renal proximal tubules and increased at the termination phase of zebrafish kidney regeneration. Notably, this change contrasts with the role of hydrogen peroxide (H2O2), which acts as an accelerator in kidney regeneration. Through experiments with penka mutants and pharmaceutical treatments, we demonstrate that PENK-A inhibits H2O2 production in a dose-dependent manner, suggesting its involvement in regulating the rate and termination of regeneration. Furthermore, H2O2 influences the expression of tcf21, a vital factor in the formation of renal progenitor cell aggregates, by remodeling H3K4me3 in renal cells. Overall, our findings highlight the regulatory role of PENK-A as a brake in kidney regeneration.

Renal stem cell

Proenkephalin

10.1038/s41467-023-42929-5

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Revealing the Inhibition of Tea Cultivar ‘Ziyan’ Root Growth Caused by High Nitrogen Based on Physiological, Metabolite, and Transcriptome Analyses

Agronomy (2023)

Wengang Xie Wei Chen Dandan Tang Xiaoqin Tan Yang Yang

Nitrogen (N) is a key regulator in the growth of tea plants and the synthesis of amino acids (AAs) and related secondary metabolites, thus affecting the yield and quality of tea leaves. Increased N fertilization significantly improves the yield and quality of tea plants, but applying excess nitrogen wastes resources and causes pollution problems. Herein, we employed morphological, physiological, metabolomic, and RNA-seq methods to study the response of ‘Ziyan’ roots to high N. High N supply induced an increase in arginine (Arg), asparagine (Asn), and glutamine (Gln) in roots and simultaneously decreased sucrose, polyphenols, and caffeine contents. High N reduced the length, volume, number, and activity of the roots by 10.63%, 25.00%, 26.95%, and 14.50%, respectively, which inhibited ‘Ziyan’ root growth, probably by disturbing the regulation of carbon and nitrogen metabolism in the tea plant. According to the Kyoto Encyclopedia of Genes and Genome (KEGG) enrichment analysis, AAs, flavonoids, and flavonol-related pathways were relatively active after supplying high N. In addition, the transcriptome analysis identified NRT1/PTR and GOGAT as key genes, and the transcription factors (e.g., AP2/ERF, MYB, and WRKY) and auxins were actively involved in the high N stress response of ‘Ziyan’ roots. These findings will help us understand the adaptive mechanism of high N supply in tea tree roots and provide a reference for guiding the fertilization of ‘Ziyan’ tea plants.

Theanine

WRKY protein domain

Nitrogen Cycle

10.3390/agronomy13040968

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Comparison of the Effect of Pruning on Plant Growth and Transcriptome Profiles in Different Tea Varieties

Agronomy (2024)

S.L. Kan Dandan Tang Lufang Feng Xiaoqin Tan Yijing Zhang

Although pruning contributes to the growth and development of new shoots, it is important to note that the growth potential and yield of tea varieties may differ after pruning due to genetic and environmental factors. In this experiment, 20 different varieties of tea plants were used to observe their potential for growth, shoot development, and other phenotypic indexes after pruning. The study aimed to determine the suitability of each variety for heavy pruning. It was concluded that there were obvious differences in tree strength and new growth after pruning of the different varieties, with ‘Zhongcha 302’ exhibiting the strongest growth and ‘Emei Wenchun’ showing the weakest growth. In order to understand the molecular mechanisms involved, a transcriptomic analysis was carried out on the two tea varieties. The results of the data indicate that the expression of CYP450 family was high in ‘Zhongcha 302’. In ‘Emei Wenchun’, the expression of NCED was higher than that in ‘Zhongcha 302’. The KEGG results indicate that pruning stimulates the expression of genes involved in phytohormone signalling and plant–pathogen interaction pathways in tea plants. The study offered scientific guidance for tea plant pruning suitability and preliminarily revealed the regulatory mechanism of new shoot growth in different tea plant varieties at the transcriptome level.

Pruning

10.3390/agronomy14061105

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Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein.

PubMed (2013)

Xiaoqin Tan Xueling Guo Huiguo Liu

To investigate the neuroprotective effect of melatonin against chronic intermittent hypoxia (CIH), the major pathophysiologic features of obstructive sleep apnea syndrome.This study was conducted between January 2011 and September 2012 in Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. Thirty 8-week Wistar rats were randomly divided into 3 groups (10 each): a control group, a vehicle-treated CIH group; and a melatonin-treated (10 mg/kg) CIH group. Rats were exposed to either intermittent hypoxia (IH) (oxygen concentration changing periodically from 21.78+/-0.65 to 6.57+/-0.57%), or air-air cycling at a rate of 30 cycles/hour, 8 hour/day for 4 weeks.The CIH exposure led to a significant decrease in superoxide dismutase (SOD) activity and anti-apoptotic protein B-cell lymphoma-2 (BCL-2) expression in the hippocampus of CIH group rats compared with that of the control group and melatonin-treated CIH group. In contrast, hippocampal neuronal apoptosis increased significantly in parallel to an augment in 3,4-methylenedioxyamphetamine (MDA) content and pro-apoptotic protein Bcl-2-associated X protein (BAX) expression in CIH group than the other 2 groups. Melatonin administration abrogated the increase in MDA activity, as well as BAX expression, and restored SOD activity and BCL-2 expression to nearly their normal levels.These results indicate melatonin can inhibit hippocampal neuron apoptosis following CIH by scavenging reactive oxygen species, up-regulating anti-apoptotic protein BCL-2 and down-regulating pro-apoptotic protein BAX, and thus, alleviate CIH-induced oxidative stress injury and produce neuroprotection effects.

Hypoxia

Intermittent hypoxia

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Citations (15)

GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer’s Disease Model Mice

Inflammation (2024)

Lingyu Zhang Zhihao Jiang Shaozhen Hu H. Ni Yijing Zhao

Occludin

10.1007/s10753-024-02133-z

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The Effects of Microinjection of Acetylcholine into Nucleus Tractus Salitarious on Electroacupuncture Against Stress Mucosa Injury in Rats

Journal of Xianning College (2007)

Xiaoqin Tan

Objective To observe the effects of acetylcholine(Ach)in nucleus tractus solitarious on electroacupuncture(EA) against gastric stress ulcer in rats.Methods A total of 84 male SD rats were randomly divided into normal control group,stress group,EA+stress group,NS+EA+stress group,Ach+EA+stress group and atropine+EA+stress group.The gastric stress ulcers models were established by restrain and water immersion.The nucleus tractus solitarious was injected by the Brain Stereota-xic Frame.The variation of the gastric ulcer index(UI) and superoxidatase(SOD) activity and malondialdehyde(MDA) level were observed in rats that were separately microinjected Ach and M receptor antagonist-atropine in the nucleus of tractus solitarius.Results Compared with stress group,EA+stress group showed that the UI and MDA level were decreased but SOD activity was increased.Pretreatment with Ach into nucleus tractus solitarious enhanced the effects of electroacupuncture against stress mucosa injury,by contrast,pretreatment with atropine significantly attenuated the same effects.Conclusion The Ach in the nucleus of tractus solitarius involve in the protective effects process of the stressing gastric mucosa lesien by EA in rats.

Malondialdehyde

Stress ulcer

Ulcer index

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