Miguel Quintanilla

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Molecular biology of malignant melanoma and other cutaneous tumors

Clinical & Translational Oncology (2006)

Mar Pons Miguel Quintanilla

10.1007/s12094-006-0046-4

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Citations (27)

Data from A Role for the Fas/FasL System in Modulating Genetic Susceptibility to T-Cell Lymphoblastic Lymphomas

María Villa‐Morales Javier Santos Eduardo Pérez-Gómez Miguel Quintanilla José Fernández‐Piqueras

<div>AbstractThe Fas/FasL system mediates induced apoptosis of immature thymocytes and peripheral T lymphocytes, but little is known about its implication in genetic susceptibility to T-cell malignancies. In this article, we report that the expression of FasL increases early in all mice after γ-radiation treatments, maintaining such high levels for a long time in mice that resisted tumor induction. However, its expression is practically absent in T-cell lymphoblastic lymphomas. Interestingly, there exist significant differences in the level of expression between two mice strains exhibiting extremely distinct susceptibilities that can be attributed to promoter functional polymorphisms. In addition, several functional nucleotide changes in the coding sequences of both Fas and FasL genes significantly affect their biological activity. These results lead us to propose that germ-line functional polymorphisms affecting either the levels of expression or the biological activity of both Fas and FasL genes could be contributing to the genetic risk to develop T-cell lymphoblastic lymphomas and support the use of radiotherapy as an adequate procedure to choose in the treatment of T-cell malignancies. [Cancer Res 2007;67(11):5107–16]</div>

Fas ligand

10.1158/0008-5472.c.6495873.v1

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Transforming Growth Factor β1Induces Squamous Carcinoma Cell Variants with Increased Metastatic Abilities and a Disorganized Cytoskeleton

Experimental Cell Research (1998)

Pilar Frontelo M Gonzalez-Garrigues Senén Vilaró Carlos Gamallo Àngels Fabra

10.1006/excr.1998.4219

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Urokinase expression and binding activity associated with the transforming growth factor β1‐induced migratory and invasive phenotype of mouse epidermal keratinocytes

Journal of Cellular Biochemistry (1999)

Juan F. Santibáñez Pilar Frontelo Maite Iglesias Jorge Martı́nez Miguel Quintanilla

10.1002/(sici)1097-4644(19990701)74:1<61::aid-jcb7>3.3.co;2-2

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Involvement of the Ras/MAPK Signaling Pathway in the Modulation of Urokinase Production and Cellular Invasiveness by Transforming Growth Factor-β1 in Transformed Keratinocytes

Biochemical and Biophysical Research Communications (2000)

Juan F. Santibáñez Maite Iglesias Pilar Frontelo Jorge Martı́nez Miguel Quintanilla

10.1006/bbrc.2000.2946

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Citations (56)

A Role for the Fas/FasL System in Modulating Genetic Susceptibility to T-Cell Lymphoblastic Lymphomas

Cancer Research (2007)

María Villa‐Morales Javíer Santos Eduardo Pérez-Gómez Miguel Quintanilla José Fernández‐Piqueras

Abstract The Fas/FasL system mediates induced apoptosis of immature thymocytes and peripheral T lymphocytes, but little is known about its implication in genetic susceptibility to T-cell malignancies. In this article, we report that the expression of FasL increases early in all mice after γ-radiation treatments, maintaining such high levels for a long time in mice that resisted tumor induction. However, its expression is practically absent in T-cell lymphoblastic lymphomas. Interestingly, there exist significant differences in the level of expression between two mice strains exhibiting extremely distinct susceptibilities that can be attributed to promoter functional polymorphisms. In addition, several functional nucleotide changes in the coding sequences of both Fas and FasL genes significantly affect their biological activity. These results lead us to propose that germ-line functional polymorphisms affecting either the levels of expression or the biological activity of both Fas and FasL genes could be contributing to the genetic risk to develop T-cell lymphoblastic lymphomas and support the use of radiotherapy as an adequate procedure to choose in the treatment of T-cell malignancies. [Cancer Res 2007;67(11):5107–16]

Fas ligand

Genetic predisposition

10.1158/0008-5472.can-06-4006

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LA MOVILIDAD GEOGRAFICA EN LA EMPRESA: UN ANALISIS PARA ESPAÑA

José Ramón Pin Pilar García Lombardia Angela Gallifa Miguel Quintanilla Lourdes Susaeta

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Supplementary Table 1 from A Role for Endoglin as a Suppressor of Malignancy during Mouse Skin Carcinogenesis

Eduardo Pérez-Gómez María Villa‐Morales Javier Santos José Fernández‐Piqueras Carlos Gamallo