Familial Mediterranean Fever (FMF) is an autosomal recessive polysystemic disease characterized by attacks of relapsing and self-limiting fever, peritonitis, pleuritis and arthritis. Rheumatoid Arthritis (RA) is an erosive, chronic, inflammatory disease that affects hand and ankle joints in polyarticular type and causes deformities. To our knowledge, development of RA in a patient with FMF has not been reported before. Therefore, we present a 48 years old case who developed RA during the course of FMF. (Turk J Rheumatol 2010; 25: 44-6)
Al›n d› ¤› Ta rih: 15.07.2008 Ka bul Ta ri hi: 11.08.2008 Abs tract We present a 60-year-old male patient who had concurrent psoriatic spondyloarthropathy and gout, which has not been reported in the literature previously. In this paper, the clinical and radiological features of both rheumatic diseases are discussed in light of the recent literature. (Turk J Rheumatol 2009; 24: 159-62)
Abstract Introduction Sepsis and septic shock are disorders of tissue perfusion and microcirculation associated with increased mortality. The role of biomarkers such as proadrenomedullin (PRO-ADM), interleukin 6 (IL-6) and neutrophil CD64 (CD64) in the diagnosis and prognosis of septic shock has been studied. Methods GCS, SOFA score, APACHE 2 score, lactate, CRP, procalcitonin, PRO-ADM, IL-6, CD64 level and 28-day mortality were evaluated in patients with septic shock followed-up in the intensive care unit of Marmara University Hospital between July 2021 and December 2021. The study was planned as prospective, non-drug clinical research Committee. Results There were no statistically significant differences between patient groups in gender, BMI, and presence of comorbidities (p > 0.05). The alive patient group had significantly higher GCS values and lower SOFA, APACHE 2, lactate and CD64 values than the dead patient group (p < 0.01). The cut-off values of laboratory parameters were determined using ROC analysis to predict mortality, SOFA and CD64 had high AUC. This is also a good indicator for mortality.The multivariate logistic regression model was estimated using the backward selection method. The mortality of ICU patients was predicted by a SOFA-value ≥ 12 (OR (95%CI) = 56.13 (5.44–578.64)), CD64 value ≥ 28.54 (OR (95% CI) = 23.78 (2.61–216.85)), and ADM-value ≥ 86.79 (OR (95% CI) = 15.86 (1.02–246.49)) (p < 0.05) . Conclusion In conclusion, serum CD64 level, PRO-ADM level, and SOFA score proved to be effective parameters for predicting prognosis and mortality in septic shock. However, IL-6 proved to be a weak biomarker and failed to predict mortality. CD64, which is easier and more practical to use, can be used instead of the SOFA score.
Amac:Ankilozan spondilit (AS) baslica sakroiliak eklem ve lomber omurga olmak uzere aksiyel iskelettutulumu ile giden kronik inflamatuar bir hastaliktir. Hastaligin patogenezinden sitokinlerin sorumlu olabilecegidusunulmektedir. Bu calismanin amaclarini AS'li hastalarda serum IL-8 duzeylerinin belirlenmesi ve IL-8duzeyleri ile hastalik aktivitesi arasindaki iliskinin saptanmasi olusturmaktadir.Gerec ve Yontem:Modifiye New York kriterlerine gore AS tanisi almis 28 hasta calismaya dahil edildi.Hastalarin klinik degerlendirilmelerinde BASDAI, BASFI, BASMI ve Maastricht Ankylosing SpondylitisEnthesis Score (MASES) indeksleri kullanildi. ELISAyontemi ile serum IL-8 duzeyleri olculdu.Bulgular: Hastalarin ortalama yas ve hastalik sureleri sirasiyla 35,4±10,8 yil ve 75±97,1 ay olarak saptandi.Serum IL-8 duzeyleri ortalama 67,3±22,9 pg/mL olarak olculdu. Serum IL-8 duzeyinin diger klinik ve laboratuarparametreler ile karsilastirilmasinda, sadece C-reaktif protein duzeyi (P=0,048) ve BASDAI (P=0,005) ileanlamli iliski gosterdigi gozlendi.Sonuc: BASDAI ve CRP AS'li hastalarin klinik aktivitelerini degerlendirmede kullanilan iki onemliparametredir. Bu calismada saptanan serum IL-8 ile BASDAI ve CRP arasindaki iliski serum IL-8 duzeylerininhastalik aktivitesinin takibinde kullanilabilecek objektif bir belirtec oldugunu gosterebilir
