W Saeger

Marienhospital Stuttgart

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Stephan Petersenn

University of Duisburg-Essen

Nicole Unger

University of Duisburg-Essen

Rolf Buslei

Sozialstiftung Bamberg

Stefan Schulz

Friedrich Schiller University Jena

Michael Buchfelder

Friedrich-Alexander-Universität Erlangen-Nürnberg

Christopher Nimsky

Center for Behavioral Brain Sciences

Klaus Mann

Ludwig-Maximilians-Universität München

R. Fahlbusch

Friedrich-Alexander-Universität Erlangen-Nürnberg

Bianca Ueberberg

Klinikum Dortmund

Missmahl Hp

Marienkrankenhaus Hamburg

Cooperative Institutions

University of Duisburg-Essen

Essen University Hospital

Universität Hamburg

Universitätsklinikum Erlangen

Medical University of Vienna

Friedrich-Alexander-Universität Erlangen-Nürnberg

Klinik und Poliklinik für Neurologie

Ludwig-Maximilians-Universität München

Medizinische Hochschule Hannover

Marienkrankenhaus Hamburg

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Adrenocortical nodules in post-mortem series. Development, functional significance, and differentiation from adenomas.

PubMed (1996)

Christina Reinhard W Saeger Bernadette Schubert

In 498 consecutive autopsy cases, the adrenal glands were light microscopically and morphometrically studied. 265 (53.7%) patients showed single or multiples nodules, 25 (5.0%) adenomas. The diameter of nodules was between 0.3 to 8.0 mm and that of adenomas between 3.2 to 28.0 mm. Clinically, 265 (36.5%) patients revealed arterial hypertension. 283 (63.5%) were normotensive. For the diagnosis of adenomas, the architecture and the cell structure were more important than the size of the tumor. Normotensive patients showed more often (55.%) nodules than hypertensive patients (52.8%). Adenomas were more frequently found in hypertensive patients. There was no correlation between age, sex and nodules, but adenomas were more frequently found in females. Normotensive patients exhibited mainly one nodule, whereas multiple nodules were found in hypertensive patients. In patients with nodules arteriosclerosis with intima hyalinosis was present in 184 (56.3%) cases, in patients without nodules in 81 (47.4%) cases. Our study clearly demonstrates that no correlation exists between the occurrence of adrenocortical nodules and age or hypertension. The etiology of adrenal nodules should be considered together with the arteriopathy.

Nodule (geology)

Etiology

Arteriosclerosis

Adrenocortical adenoma

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Citations (28)

Pituicytoma: A low-grade glioma of the neurohypophysis – case report and review of literature

Experimental and Clinical Endocrinology & Diabetes (2007)

Jürgen Kreutzer Christopher Nimsky Ingmar Bluemcke Michael Buchfelder W Saeger

Objective: Pituicytomas are rare primary tumors of the neurohypophysis. Their histogenesis is still under debate. At present they are thought to derive from neurohypophyseal pituicytes, but ultrastructural findings also suggest a possible origin from folliculostellate cells of the adenohypophysis. Although pituicytomas are biologically and histologically benign, their skull base location can make a complete surgical resection difficult with consecutively high incidence of recurrence.

Histogenesis

Surgical resection

10.1055/s-2007-972357

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Citations (0)

Somatostatin receptor subtypes 15 in pituitary tumors of various etiologies: investigation by immunohistochemistry

8th European Congress of Endocrinology incorporating the British Endocrine Societies (2006)

Nicole Unger Inna Serdiuk W Saeger H Wiedemeyer de Nes J Van

Pituitary Tumors

Etiology

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Carcinomas of the pituitary: definition and review of the literature.

PubMed (1995)

Dorothee Lübke W Saeger

Pituitary carcinomas are defined by their disconnected mode of extension, i.e. by the existence of intra- or extra-cerebral metastases. Since an invasive growth in the sella and its neighboring regions can also be noted in many pituitary adenomas, this invasion cannot be counted as a criterion for malignancy. Almost all pituitary carcinomas stem from previously operated or irradiated invasive adenomas. Like adenomas, they are classified with regard to the presumable cell of origin and the hormone which was produced contingently. Together with 67 pituitary carcinomas already published, three own cases are subject to a critical, summarizing judgement.

Pituitary Tumors

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Citations (46)

Eine Patientin mit ACTH-produzierendem Hypophysentumor und Lebermetastasen

DMW - Deutsche Medizinische Wochenschrift (2008)

Maximilian Richter W Saeger Eckhard Leifke R. Fahlbusch A. von zur Mühlen

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study

10.1055/s-2007-1023906

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Citations (9)

Expression of Ghrelin and its Receptor in Human Tissues

Hormone and Metabolic Research (2009)

Bianca Ueberberg Nicole Unger W Saeger Kay Mann Stephan Petersenn

Ghrelin is a peptide thought to be involved in the regulation of appetite. Furthermore, significant effects on the release of growth hormone (GH) and ACTH were demonstrated. Contributing to the physiological relevance of this hormone, we investigated the expression of ghrelin and its receptor (GHS-R) in several normal human tissues. RNA samples (BD Biosciences) underwent one-step TaqMan Real-Time RT-PCR. Immunohistochemistry was performed on paraffin-embedded tissues using specific primary antibodies against ghrelin and its receptor. Relevant ghrelin mRNA levels were detected in all human tissues with the highest levels in stomach, pituitary, and small intestine. By immunohistochemistry, ghrelin peptide expression was detectable in reproductive and endocrine organs (ovary, anterior pituitary, adrenal gland), and organs of the gastrointestinal tract (stomach, pancreas). GHS-R1a mRNA expression was demonstrated in 10 of 24 human organs analyzed with the highest levels in pituitary, adrenal gland, and spinal cord. Expression of the receptor peptide was detected by immunohistochemistry in endocrine and reproductive organs (anterior pituitary, thyroid, pancreas, testis), parts of the CNS (cerebrum, cerebellum), and in single cells of bone marrow. Expression of both ghrelin and its receptor in endocrine and reproductive organs may indicate new endocrine or paracrine mechanisms of regulation in these tissues.

Enteroendocrine cell

Endocrine gland

10.1055/s-0029-1233462

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Citations (125)

[Immunohistology of pituitary adenomas--significance for classification and clinical correlation].

PubMed (1986)

W Saeger Cornelia Schulze Lüdecke Dk

Clinical Significance

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Citations (2)

[Sheehan syndrome with fatal course. Morphologic and immunohistologic studies of a case].

PubMed (1984)

W Saeger H Kühn

Course (navigation)

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Citations (2)

Immunohistochemical expression of somatostatin receptor subtypes in various normal human tissues

Experimental and Clinical Endocrinology & Diabetes (2005)

Nicole Unger H Tourné A Redmann Stefan Schulz W Saeger

Somatostatin is a tetradecapeptide, which mediates its action via five receptor subtypes (sst1–5). Because of the inhibitory and antiproliferative effects, long-acting somatostatin analogues were developed. While octreotide binds with high affinity to sst2a only, the new analogue SOM230 demonstrates high affinity to sst1, 3 and 5 in addition.

Somatostatin receptor 1

Somatostatin receptor 3

10.1055/s-2005-862795

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Citations (2)

Differential Expression of Ghrelin and its Receptor (GHS-R1a) in Various Adrenal Tumors and Normal Adrenal Gland

Hormone and Metabolic Research (2008)

Bianca Ueberberg Nicole Unger Sien‐Yi Sheu Martin K. Walz K. W. Schmid

Ghrelin is a newly characterized, widely distributed peptide thought to be involved in the regulation of appetite. Significant effects on the release of growth hormone (GH) and ACTH have been demonstrated. This study compares the expression of ghrelin and its receptor (GHS-R) in various adrenal tumors and normal adrenal gland. Normal adrenal tissue was obtained after autopsy. Tissue was obtained from 13 pheochromocytomas (PHEOs), 15 cortisol-secreting adenomas (CPAs), 12 aldosterone-secreting adenomas (APAs), and 16 nonfunctional adenomas (NFAs) following laparoscopic surgery. Expression of ghrelin and GHS-R1a was investigated on RNA levels by using real-time reverse transcription polymerase chain reaction (RT-PCR) and on protein levels by using immunohistochemistry. In the seven normal adrenal glands analyzed, ghrelin mRNA levels were 12-fold lower than in stomach. Ghrelin protein expression was confirmed by immunohistochemistry. In all adrenal tumors, relevant levels of ghrelin mRNA were observed, with significantly lower expression in PHEOs and APAs than in normal adrenal gland. Ghrelin protein was detected in 0% of PHEOs, 55% of APAs, 87% of CPAs, and 54% of NFAs. GHS-R1a mRNA expression was detectable in normal adrenal gland, but the receptor protein was absent. In adrenal tumors, detectable levels of receptor mRNA were found in 38% of PHEOs, 13% of CPAs, and 25% of NFAs. GHS-R1a protein was absent in the majority of adrenal tumors. Expression of ghrelin in normal adrenal gland and adrenal tumors may indicate some unknown physiological function. The pathophysiological relevance of ghrelin expression in adrenal tumors remains to be investigated.

10.1055/s-2007-1004574

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Citations (22)