Tomotoshi Imanaga

Nippon Steel Yawata Memorial Hospital

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Chiharu Yoshii

University of Occupational and Environmental Health Japan

Kazuhiro Yatera

University of Occupational and Environmental Health Japan

Masamitsu Kido

Kyoto Prefectural University of Medicine

Hiroshi Mukae

Nagasaki University Hospital

Toshinari Hayashi

National Defense Medical College Hospital

Hiroshi Ishimoto

Nagasaki University

Keishi Oda

University of Occupational and Environmental Health Japan

Atsushi Moriwaki

Fukuoka Hospital

Tatsunori Kawajiri

University of Occupational and Environmental Health Japan

Koichi Takayama

Kyoto Prefectural University of Medicine

Cooperative Institutions

University of Occupational and Environmental Health Japan

Kyushu University

Society of Thoracic Surgeons

Deutsches Herzzentrum der Charité

Duke Medical Center

Duke University

Deutsches Herzzentrum München

New York University

Nagoya University

Fukuoka University

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The Annals of Thoracic Surgery (2010)

Andrew Chang Jungwha Lee Konrad Teodor Sawicki Allan Pickens Mark B. Orringer

10.1016/s0003-4975(10)00536-9

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Citations (0)

[Efficacy and safety of sitafloxacin for lower respiratory tract infections].

PubMed (2011)

Hiroshi Mukae Kazuhiro Yatera Shuya Nagata Kei Yamasaki Chinatsu Nishida

Respiratory tract

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Bilateral Massive Pleural Effusions Caused by Uremic Pleuritis.

Internal Medicine (2001)

Chiharu Yoshii Shiho T. Morita Masaki Tokunaga Kazuhiro Yatera Toshinari Hayashi

A 61-year-old man was started on hemodialysis in June 1998. Just after the commencement of dialysis, a chest X-ray film revealed bilateral pleural effusions. The effusions were hemorrhagic and exudative, and did not respond to dialysis. He was transferred to our university hospital on October 8, 1998. Repeated thoracentesis demonstrated hemorrhagic and exudative characteristics without any diagnostic evidence. Pleural biopsies showed fibrosis and lymphocyte infiltration. The effusions were massive and did not respond to treatments including hemodialysis, repeatedly performed pleurodesis and the administration of antituberculous drugs. He died of respiratory failure on December 30, 1998. The autopsy confirmed bilateral fibrinous pleuritis without any underlying infections or malignancy. We diagnosed this case as uremic pleuritis from this clinical course and the autopsy findings. The clinical entity of uremic pleuritis was recognized as a complication of patients with hemodialysis in 1969. Uremic pleuritis generally responds to continued hemodialysis and the prognosis is usually good. However, some case reports demonstrated that surgical decortication is only indicated in cases with a severe clinical course. The clinical course of the present case was progressive and fatal. Uremic pleuritis is a serious complication of hemodialysis, which may lead to death.(Internal Medicine 40: 646-649, 2001)

Thoracentesis

Decortication

Pleurodesis

Pleurisy

Hemothorax

10.2169/internalmedicine.40.646

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Citations (13)

[A case of Osler-Weber-Rendu syndrome: therapeutic embolization of the pulmonary artery and bronchial artery].

PubMed (2005)

Atsushi Moriwaki Tomotoshi Imanaga Takako Hirota Yohko Kakeda Naoki Miyazaki

We encountered a case in which the symptoms of hypoxia and hemoptysis improved after performing repeated pulmonary artery embolizations and bronchial artery embolization. A 22-year-old man was hospitalized in our institution with high fever, headache and unconsciousness in May of 2001. Subendocranial abscess was diagnosed, so we performed antibiotic therapy and drainage, but at that time he showed symptoms of hypoxia. We diagnosed Osler-Weber-Rendu syndrome because of multiple small nodular shadows in his chest CT, multiple arteriovenous fistulae in both lungs on pulmonary arteriography, and telangiectasis. We performed pulmonary artery embolization 6 times, and his hypoxia and right to left shunts improved. In the course of our therapy, hemoptysis appeared and dilatation of vessels was detected in the left bronchial arteriography, so we performed embolization of the left bronchial artery and the symptom improved. We concluded that we should take care to detect not only pulmonary arterial lesions but also bronchial arterial leisions in the diagnosis and therapy of respiratory symptoms of Osler-Weber-Rendu syndrome.

Bronchial artery

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Phase II study of concurrent thoracic radiotherapy in combination with weekly paclitaxel plus carboplatin in locally advanced non-small cell lung cancer: LOGIK0401

Cancer Chemotherapy and Pharmacology (2013)

Koichi Takayama Koji Inoue Shoji Tokunaga Takemasa Matsumoto Tsukasa Oshima

Carboplatin

10.1007/s00280-013-2335-2

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[A case of lymphangioleiomyomatosis with carcinomatous lymphangiosis].

PubMed (2001)

Y. Matsumoto Chiharu Yoshii Tomotoshi Imanaga Tetsuji Hayashi Katsuhisa Kawanami

A 66-year-old woman had a history of partial gastrectomy and resection of the residual stomach because of early gastric cancer and its recurrence. She had been suffering from dyspnea on effort, hemosputum, and cough since the age of 52 years. Chronic pulmonary emphysema and bronchial asthma were diagnosed when she was 59. On January 31, 1996, she was admitted to UOEH hospital with a complaint of increased dyspnea. In spite of treatment with oxygen, steroid, and inhaled anti-cholinergic agent, her condition deteriorated. Subsequently, she had DIC, respiratory failure and reticulolinear opacities were seen on chest radiographs, and she died 2 weeks after admission. At autopsy, the lung specimen revealed numerous cystic spaces surrounded by a proliferation of smooth muscle cells. Immunohistological examination showed these cells to be positive for HMB-45. Signet cells were seen in the lymphatics and vessels, and hemosiderin-laden macrophages were found in the alveolar spaces. This was a rare case of lymphangioleiomyomatosis with carcinomatous lymphangiosis.

Lymphangioleiomyomatosis

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Increased Levels of Platelet-Associated Immunoglobulin G in a Patient With Pulmonary Adenocarcinoma

The Annals of Thoracic Surgery (2010)

Shohei Yoshiya Riichiroh Maruyama Dai Kitagawa Junko Tanaka Ryuji Ohta

This report describes a rare case of thrombocytopenia with high levels of platelet-associated immunoglobulin G (PA-IgG) in a patient with an adenocarcinoma of the lung. After surgical resection, the platelet count gradually increased and the serum PA-IgG levels decreased to within normal reference ranges. These findings suggest a relationship between pulmonary adenocarcinoma and PA-IgG.

Pulmonary adenocarcinoma

10.1016/j.athoracsur.2009.08.036

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[Pulmonary involvement in acute febrile neutrophilic dermatosis (Sweet's syndrome)].

PubMed (2000)

Tomotoshi Imanaga T. Hayashi Chiharu Yoshii Sumie Suzuki Kazuhiro Yatera

We encountered a 55-year-old man with pulmonary involvement in acute febrile neutrophilic dermatosis (Sweet's syndrome). He had been treated with steroids for Sweet's syndrome for 2 years, and on September 17, 1998 presented with a cough and a fever of 38.9 degrees C. Physical examination revealed fine crackles at the bases of both lungs. Chest radiography and computed tomography demonstrated reticular and nodular infiltrates in both lungs. Treatment with a variety of antibiotic agents and an antifungal agent was not effective. Sputum culture was sterile and bronchial washings were negative for infectious pathogens. Transbronchial biopsy revealed a mild chronic interstitial infiltrate and an inflammatory exudate in bronchiolo-alveolar tissue. The pulmonary lesions and cutaneous lesions were resolved by intradermal injections of triamcinolone acetonide in addition to oral prednisolone. Although the apparent neutrophilic infiltrates cited by earlier reports were not observed in transbronchial biopsy specimens, the clinical course in this case suggested that our patient had Sweet's syndrome with pulmonary involvement.

Sweet's syndrome

Crackles

Prednisolone

Chest radiograph

Productive Cough

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Welder''s Pneumoconiosis: Diagnostic Usefulness of High-resolution Computed Tomography and Ferritin Determinations in Bronchoalveolar Lavage Fluid

Internal Medicine (2002)

Chiharu Yoshii Tsuneo Matsuyama Akiko Takazawa Toshiro Ito Kazuhiro Yatera

Objective We assessed the usefulness of high-resolution computed tomography (HRCT) and ferritin determinations in bronchoalveolar lavage (BAL) fluid for diagnosis of welder's pneumoconiosis. Patients and Methods We investigated 11 patients with welder's pneumoconiosis who were 34 to 67 years old and had been welding for 17 to 45 years. Ten patients were current smokers. We performed chest radiography and HRCT, and measured serum ferritin on all 11 patients. We obtained BAL fluid in 9 cases and transbronchial lung biopsy (TBLB) specimens in 7. Ferritin concentrations in BAL fluid were compared with those in welders without pneumoconiosis and other pneumoconiosis cases. Results HRCT revealed small centrilobular nodules in 9 cases, mild fibrotic changes in 3, and emphysematous changes in 3. Serum ferritin concentrations were elevated (>240 ng/ml) in 10 cases. Ferritin concentrations in BAL fluid were higher in welder's pneumoconiosis than in the occupational control group. Conclusion In welder's pneumoconiosis, small centrilobular nodules are frequently seen on HRCT, and ferritin shows elevations in serum and/or BAL fluid. Such ferritin determinations are of value in diagnosis.(Internal Medicine 41: 1111-1117, 2002)

Pneumoconiosis

High-resolution computed tomography

10.2169/internalmedicine.41.1111

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Citations (32)

[A brain abscess as a complication of hepatopulmonary syndrome coexisting with interstitial pneumonia].

PubMed (2011)

Toyoshi Yanagihara Atsushi Moriwaki Nanae Seki Kentaro Akata Tomotoshi Imanaga

A 76-year-old woman with a 20-year history of chronic hepatitis C was referred to our hospital for worsening exertional dyspnea. She had been given a diagnosis of interstitial pneumonia based on chest computed tomography findings 5 years previously. Contrast-enhanced echocardiography confirmed an intrapulmonary right-to-left shunt, and therefore we diagnosed hepatopulmonary syndrome comorbid with interstitial pneumonia. In July 2009 she was admitted to our hospital with a low grade fever, headache, and vomiting. We diagnosed a left cerebellar brain abscess caused by Streptococcus intermedius. She underwent stereotactic burr-hole drainage and received vancomycin, piperacillin and cefotaxime. Cases of brain abscess secondary to hepatopulmonary syndrome are rare. Nevertheless, we should be aware of this complication of hepatopulmonary syndrome.

Hepatopulmonary syndrome

Streptococcus intermedius

Brain abscess

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Citations (5)