Taimoor Ashraf Khan

Khyber Teaching Hospital

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Dong‐Qing Wei

Shanghai Jiao Tong University

Abbas Khan

Sunway University

Syed Shujait Ali

University of Swat

Muhammad Suleman

University of Swat

Muhammad Abdullah Zahid

Monash Health

Fakhar Humayun

National University of Medical Sciences

Anwar Mohammad

Dasman Diabetes Institute

Sheharyar Zameer

Military Hospital

Teyyeb Azeem Janjua

Armed Forces Institute of Pathology

Saquib Naeem

National University of Medical Sciences

Cooperative Institutions

National University of Medical Sciences

100

Combined Military Hospital

Institute of Ophthalmology

Military Hospital

Army Medical College

Monash Health

Quaid-i-Azam University

University of Swat

Armed Forces Institute of Pathology

COMSATS University Islamabad

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MALIGNANCY IN MULTINODULAR GOITER-POST THYROIDECTOMY: A PROSPECTIVE STUDY

Pakistan Armed Forces Medical Journal (2021)

Fizza Naeem Sayed Nusrat Raza Taimoor Ashraf Khan

Objective: To find out the frequency and types of malignancy in patients treated surgically for nontoxicmultinodular goiter and its correlation in different age groups and gender. Study Design: Cross-sectional study. Place and Duration of Study: Department of ENT, Combined Military Hospital Rawalpindi, from Dec 2018 toDec 2019. Methodology: A total of 116 patients operated for nontoxic multinodular goiter were included in the study.Demographic details along with pre-op Ultrasonography findings, Fine Needle Aspiration Cytology, thyroidfunction test results and post-op histopathological reports of the thyroid specimen were entered on pre-designed proforma. Results were analyzed using the Statistical Package for Social Sciences (SPSS) Version 22. Results: Age ranges from 19 to 70 years (mean 43.51 years). Out of 116 cases operated for multinodular goiter,37 (31.8%) had malignant thyroid lesions (13 males, 24 females). Papillary carcinoma of the thyroid (45.9%) wasthe commonest malignancy followed by a follicular variant of papillary carcinoma (24.3%). The most common age group with malignancies was 49-58 years. Conclusion: Malignant Thyroid cancers showed a female preponderance and were most common in age group49-58 years. Papillary carcinoma of thyroid was the commonest tumor. Radical thyroid surgery is a recommended surgical management option for nontoxic Multinodular goiter.

Multinodular goiter

10.51253/pafmj.v71i1.4653

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The Omicron (B.1.1.529) variant of SARS-CoV-2 binds to the hACE2 receptor more strongly and escapes the antibody response: Insights from structural and simulation data

International Journal of Biological Macromolecules (2022)

Abbas Khan Hira Waris Memoona Rafique Muhammad Suleman Anwar Mohammad

spike protein

10.1016/j.ijbiomac.2022.01.059

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ASSOCIATION OF AGE WITH HEARING REHABILITATION AFTER COCHLEAR IMPLANT

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

Fizza Naeem Sayed Nusrat Raza Taimoor Ashraf Khan Um e Aiman

Objective: To determine the hearing outcomes following unilateral cochlear implantation & speech therapy in patients with bilateral severe to profound sensorineural hearing loss. Study Design: Prospective observational study. Place and Duration of Study: Department of ENT, Head and Neck Surgery, Combined Military Hospital Rawalpindi, from Dec 2018 to Dec 2019. Methodology: We included 40 cases who underwent unilateral cochlear implantation at the Cochlear Implant Centre of Combined Military Hospital Rawalpindi and later on had at least 6 months of continuous speech rehabilitation (post-activation) at Speech Rehab Center of the same hospital. All patients had their cochlear implants activated 6 weeks after the surgery. Auditory rehabilitation was assessed continuously at each session by a single speech therapist and documented using the “5 stages of listening i.e. has a very good vocabulary, has a basic vocabulary, understands words, responds to sounds, doubtful response to sound.” Results: Out of 40 patients, 22 (55%) were male and 18 (45%) were females. Age at the time of cochlear implan-tation ranged from 2 to 8.4 years with a mean age of 4.5 ± 1.34 years. At 6 months 50% of children in age group 2-3 years had clinically and statistically significant response to speech rehabilitation post cochlear implant surgery. Conclusion: We concluded that a cochlear implant is a safe and highly effective treatment for bilateral severe to profound sensorineural deafness in pediatric age from 2 to 8 years while the best results documented in our study are for age 2 and 3 years at implantation.

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Spasm of Near Synkinetic Reflex: Outcomes of a Comprehensive Management Protocol

Pakistan Armed Forces Medical Journal (2023)

Abdul Qadir Saquib Naeem Taimoor Ashraf Khan Talha Liaqat Muhammad Asad Farooq

Objective: To find out the frequency of spasm of near reflex presenting to our clinic and outline the management outcomes. Study Design: Quasi-experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from May to Dec 2022. Methodology: A patient who was suspected to have spasm of near reflex underwent subjective and objective refraction and detailed orthoptic evaluation. Dry and cycloplegic retinoscopy was obtained along with post-mydriatic refraction achieved after 3 days of Cycloplegic. Spasm of near reflex was categorized as mild if it resolves on administration of a weaker cycloplegic drug like cyclopentolate, moderate if administration of stronger cycloplegic i.e., atropine/homatropine is required or severe if long term home therapy of atropine 0.5% once daily is required. Results: Our study included 236 patients with suspected spasm of near reflex, among which it was confirmed in 200 only. Of the 200 patients with confirmed spasm of near reflex, there were 74 mild cases (37%), with no spasm of near reflex during their post-cycloplegic visit. Eighty-eight patients (44%) had moderate spasm of near reflex that was relieved by the post atropine examination. Whereas, 38 patients (19%) had severe spasm of near reflex, requiring long-term atropine 0.5% management. Conclusion: Spasm of near reflex is often a diagnostic dilemma which is otherwise not very difficult to treat. Most of such cases were found to be mild to moderate having good visual outcomes to once or twice application of moderate (Cyclopentolate 1%) to stronger acting Cycloplegic eye drops (Atropine 1%).

Cyclopentolate

Cycloplegia

Retinoscopy

10.51253/pafmj.v73isuppl-2.9952

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Comparison of Acid Base Status and Electrolytes in Individuals with Prediabetes, Diabetes and Normoglycemia

Pakistan Armed Forces Medical Journal (2023)

Asma A. Khan Naveed Asif Taimoor Ashraf Khan Azadi Khan Sana Iqbal

Objective: To determine the acid-base status and electrolytes in individuals with pre-diabetes, diabetes and normoglycemia. Study Design: Cross-sectional study. Place and Duration of Study: Department of Chemical Pathology, Combined Military Hospital, Quetta Pakistan, from Jan2020 to Jun 2020. Methodology: Two hundred study participants were part of this cross-sectional study. Study participants were divided into 3 groups based on plasma glucose levels normoglycemics, prediabetics, and patients with diabetes. Sample for serum electrolytes, plasma glucose, and venous blood gases was taken and analyzed. Results were calculated statistically by using SPSS 21. Results: Mean age of study participants as 40.11+/-13.93 years. Out of these, 130(65%) study participants were males and 70(35%) were females. Out of these 200study participants, 105(52.5%) had sodium level <135mmol/L and serum potassium <3.5mmol/L, 90(45%) had serum sodium level between 135-145mmol/L and serum potassium level between 3.5-5.5mmol/L and only 5(2.5%) had serum sodium level >145mmol/Land serum potassium >5.5mmol/L. Similarly, 5(2.5%) study participants had serum chloride level <98mmol/L, 84(42%) between 98-108 mmol/L and 111(55.5%) ad >108mmol/L with a mean of 106±5 mmol/L. Regarding acid base disturbance, metabolic acidosis was observed in patients with diabetes as compared to normoglycemic and prediabetics. Conclusion: Patients with different stages of hyperglycemia have a different pattern of electrolytes and acid-base status which can be used as surrogate markers of normoglycemia, prediabetes, and diabetes.

Prediabetes

Cross-sectional study

10.51253/pafmj.v73isuppl-1.5491

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PREDICTING SEVERITY AND VISUAL OUTCOMES OF EYE TRAUMA FOLLOWING TREATEMENT, USING OCULAR TRAUMA SCALE

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

Teyyeb Azeem Janjua Taimoor Ashraf Khan Abdullah Anis Raja Muhammad Abdullah Zahid

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LIPID-LOWERING EFFICACY OF 20 MG SIMVASTATIN VERSUS 5 MG ROSUVASTATIN IN PATIENTS OF TYPE 2 DIABETES

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

Hafiz Muhammad Yasir Rehman Abdul Latif Khattak Taimoor Ashraf Khan Abdul Moueed Tariq Shahzeb Ahmed Satti

Objective: To compare the efficacy of Rosuvastatin 5mg and Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed patients with type 2 diabetes. Study Design: Quasi-experimental study. Place and Duration of Study: Department of General Medicine, Pak Emirates Military Hospital (PEMH), Rawalpindi, from Jul 2017 to Jan 2018. Methodology: Patients of type 2 diabetes with hypercholesterolemia (mean LDL-C levels >100 mg/dl) were included in the study. In a sample of 100 patients, half of the patients were in the Rosuvastatin 5mg group (group A) while half patients were in the Simvastatin 20mg group (group B). Non-probability consecutive sampling was done. We followed up the patients for 6 weeks. All the laboratory investigations were performed from the laboratory of the same hospital. Investigator himself recorded all the information including name, age, gender, weight, LDL-C levels, Renal function test reports and CK-MB levels in a self-designed, self-administered proforma. Data were analyzed with statistical analysis program SPSS V 23. Results: Age range in this study was from 35 to 60 years with a mean age of 46.980 ± 6.31 years in group A vs 48.520 ± 5.61 years in group B. Mean LDL-C Levels were 149.460 ± 25.76 mg/dl in group A vs 146.960 ± 22.92 mg/dl in group B. Mean weight was 82.880 ± 9.17 kg in group A vs 88.660 ± 10.33kg in group B. Male gender was dominant in both group (70% and 72%). In group A, efficacy was seen in 40 (80%) patients as compared to 24 (48%) patients in group B (p<0.001). Conclusion: Rosuvastatin 5mg tablet was more effective than Simvastatin 20mg in reducing low-density lipoprotein cholesterol in newly diagnosed type 2 diabetes patients.

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Towards specie-specific ensemble vaccine candidates against mammarenaviruses using optimized structural vaccinology pipeline and molecular modelling approaches

Microbial Pathogenesis (2022)

Taimoor Ashraf Khan Arooj Muzaffar Rana Muhammad Shoaib Abbas Khan Yasir Waheed

Reverse vaccinology

10.1016/j.micpath.2022.105793

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A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from Mycobacterium tuberculosis

RSC Advances (2021)

Taimoor Ashraf Khan Abbas Khan Syed Shujait Ali Shahid Ali Dong‐Qing Wei

Tuberculosis is still one of the top 10 causes of death worldwide, particularly with the emergence of multidrug-resistant tuberculosis.

Pyrazinamide

Molecular mechanics

10.1039/d0ra09326b

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PREDICTING SEVERITY AND VISUAL OUTCOMES OF EYE TRAUMA FOLLOWING TREATEMENT, USING OCULAR TRAUMA SCALE

PAFMJ (2020)

Teyyeb Azeem Janjua Taimoor Ashraf Khan Abdullah Anis Raja Muhammad Abdullah Zahid

Objective: To predict the severity and visual outcomes following treatment in patients sustaining eye trauma using ocular trauma scale. Study Design: Retrospective case series. Place and Duration of Study: Armed Forces Institute of Ophthalmology Rawalpindi, from Jan 2015 to Jan 2017. Methodology: A total of 50 patients with eye trauma were included. Injuries were classified according to 'Birmingham Eye Trauma Terminology System‟. „Ocular trauma scale' was used to predict the visual outcome. We analyzed the data by using Statistical Package for Social Sciences version 22. Results: Patients‟ mean age was 30 ± 5.632 years. Forty-nine (98%) had open globe injury and 01 (2%) had closed globe injury. Primary & secondary repair was performed and pars plana vitrectomy in 28 (56%), patients was most commonly performed procedure. Based on best-corrected visual acuity vision of 4 (8%) patients significantly improved. Twenty (40%) were bilaterally blind while 16 (32%) were unilaterally blind in right eye and 10 (20%) were blind in left eye. Conclusion: Open globe injuries of grade IV and V on Ocular trauma scale were found to be severe with the worst visual and anatomical outcomes. Use of protective eye equipment in high-risk individuals including welders, and sportsmen etc would have an invaluable role in reducing the incidence of ocular trauma and its severity.

Eye injuries

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