Giuseppe Ghizzoni

IRCCS Ospedale San Raffaele

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i-10 index

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C Rusconi

University of Brescia

Pompilio Faggiano

Fondazione Poliambulanza Istituto Ospedaliero

C Oneglia

Azienda Ospedaliera Fatebenefratelli e Oftalmico

Alberico Sorgato

Fondazione Poliambulanza Istituto Ospedaliero

T. Sabatini

Gruppo di Ricerca Geriatrica

Tony Sabatini

Fondazione Poliambulanza Istituto Ospedaliero

Armando Gardini

IRCCS Policlinico San Donato

U Simoncelli

Fondazione Poliambulanza Istituto Ospedaliero

C. Rusconi

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Ciro Vella

Istituti di Ricovero e Cura a Carattere Scientifico

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

Vita-Salute San Raffaele University

IRCCS Ospedale San Raffaele

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

Ospedale Valduce

Ospedale Sant'Orsola di Brescia

San Raffaele University of Rome

University of Brescia

Azienda Ospedaliera Fatebenefratelli e Oftalmico

Kansai Medical University

Author Statistics

Papers

Citation

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i-10 index

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[Effectiveness and tolerability of simvastatin in patients with moderate-to-severe hypercholesterolemia. Results of a 12-month study].

PubMed (1993)

Giuseppe Ghizzoni Christopher Rusconi Pompilio Faggiano T. Sabatini C Oneglia

Several epidemiological and clinical studies have underlined the close relationship between hypercholesterolemia and risk of coronary heart disease suggesting the opportunity of treating hypercholesterolemic patients according to their associated risk factors. Simvastatin, a drug for the treatment of hypercholesterolemia, is a competitive inhibitor of 3-Hydroxy-Methyl-Glutaryl-CoA reductase, the rate limiting enzyme in cholesterol biosynthesis. In the present study we have assessed the efficacy, safety and tolerability of simvastatin (10-20 mg) administered once daily for a period of 12 months to 50 patients with coronary heart disease (CHD) or at high risk for CHD according to the National Cholesterol Education Program. All patients underwent complete physical examination and laboratory safety tests (including blood cell count, liver function tests, creatine kinase and lipid profile) at baseline and every 6 weeks during treatment. Simvastatin was highly effective in reducing total and LDL cholesterol (-25% and -35% respectively). No significant effect on HDL cholesterol or triglycerides was obtained. Two patients were excluded after 6 weeks of treatment because of a serum creatine kinase increase (more than twice normal values). This was the only drug related side effect. In conclusion our data show that: a) simvastatin treatment is well accepted and compliance is good; b) the effect of simvastatin is evident after the first 6 weeks of treatment and is maintained during the whole treatment time; c) simvastatin is highly effective in lowering total and LDL cholesterol. When considering a patient who has had an atherosclerotic event the best deterrent to the occurrence of a subsequent event (secondary prevention) could be reduction of serum total and LDL cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)

Tolerability

Creatine kinase

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Citations (1)

Congestive heart failure due to rapid right ventricular obliteration by metastatic malignant melanoma.

PubMed (1996)

C. Rusconi P Faggiano Giuseppe Ghizzoni Alberico Sorgato Gaetano Minzioni

We describe a 47-year-old man with a history of malignant melanoma, starting with a resection from his left thigh and followed, 4 years later, by a metastatic melanoma in the right ventricle. Within a few days, hemodynamic compromise occurred combined with evidence of an impressive intracavitary growth of the tumor causing obstruction of the right ventricular inflow and outflow tract. Echocardiography was valuable in the assessment of neoplastic cardiac involvement and was useful in detecting rapid right ventricular cavity obliteration by the expansion of the metastatic mass.

Ventricular outflow tract

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Citations (6)

8.1 ECHO-Doppler study of interatrial conduction times with interatrial septum pacing

EP Europace (2003)

Armando Gardini C Oneglia G Benedini Giuseppe Ghizzoni C Rusconi

Background: atrial fibrillation (AF) is the most common arrhythmia in clinical practice.Drug therapy has only a limited effect on suppression of AF.Preventive Pacing Algorithms and Antitachy Pacing strategies (ATP) are increasingly used in patients with sinus node disease and paroxysmal atrial arrhythmias.Methods: in 40 patients with sick sinus syndrome and a class I/II indication for pacemaker implantation and documented paroxysmal or persistent atrial arrhythmias a Medtronic AT-500 pacemaker was implanted.Patients at stable antiarrhythmic medication and with documented AF/AT in the pacemaker memory 6-8 weeks after hospital discharge were eligible for the study.Pacemakers were programmed in DDDR-mode with all preventive algorithms and ATP off.After 3 months all preventive algorithms and ATP-therapies were activated for another 3 months period.Results: activating the preventive pacing algorithms resulted in a decrease of the median AF-burden by 33%.ATP was successful in 53% of 12776 treated episodes.Conclusion: AF-burden can be reduced by preventive pacing algorithms in patients with sick sinus syndrome and paroxysmal atrial arrhythmias.ATP therapies are effective in terminating atrial tachyarrhythmias.

Interatrial septum

10.1016/eupace/4.supplement_1.a13-b

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Citations (0)

Announcement

Cardiology (1995)

Pompilio Faggiano C. Rusconi Tony Sabatini Giuseppe Ghizzoni Alberico Sorgato

10.1159/000176866

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Citations (0)

Left Ventricular Remodeling in Valvular Aortic Stenosis

CHEST Journal (1994)

Pompilio Faggiano Cesare Rnsconi Giuseppe Ghizzoni

Pressure overload

Concentric hypertrophy

Volume overload

Ventricular remodeling

Pathophysiology

Ventricular hypertrophy

10.1378/chest.105.4.1273

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Citations (7)

I nitrati nello scompenso cardiaco: Effetti emodinamici e implicazioni cliniche

Cardiology (1994)

Pompilio Faggiano C Rusconi Giuseppe Ghizzoni

It is a common opinion that nitrate therapy may have a harmful effect on cardiac output in patients with congestive heart failure when left ventricular filling pressure is markedly reduced. In this study, we evaluated, using hemodynamic monitoring with Swan-Ganz catheterization, the effects on cardiac output and filling pressures of high-dose intravenous nitroglycerin in 8 patients with dilated cardiomyopathy and severe heart failure. At maximal doses of nitroglycerin utilized (350 +/- 220 micrograms/m, range 100-800), a significant reduction in right atrial pressure (from 4 +/- 3.5 to -1 +/- 4 mm Hg, p < 0.001) and pulmonary capillary wedge pressure (from 16 +/- 5 to 7 +/- 3 mm Hg, p < 0.001) was observed. Furthermore, we found neither a significant reduction in systemic vascular resistances (from 1,500 +/- 329 to 1,320 +/- 330 dynes/s/cm-5) nor changes in heart rate or blood pressure. Finally, stroke volume and cardiac index increased slightly although not significantly (from 62 +/- 18 to 70 +/- 16 ml and from 2.3 +/- 0.45 to 2.65 +/- 0.4 l/m/m2). The preservation of stroke volume despite a marked reduction in left ventricular filling pressure can be explained by a reduction in pericardial constraint and of mitral regurgitation induced by nitroglycerin. The clinical implications of these hemodynamic results are discussed with emphasis on the short- and long-term use of nitrates in congestive heart failure.

Pulmonary wedge pressure

Cardiac index

Dilated Cardiomyopathy

10.1159/000176445

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Citations (2)

Prevalence of isolated left ventricular diastolic dysfunction in hypertension as assessed by combined transmitral and pulmonary vein flow Doppler study

The American Journal of Cardiology (2001)

C Rusconi Tony Sabatini Pompilio Faggiano Giuseppe Ghizzoni C Oneglia

10.1016/s0002-9149(00)01378-3

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Citations (33)

Elenco soggetti

Cardiology (1994)

Ermanno Eleuteri C Montemartini Giuśeppe Specchia A Cecchi C. Cinelli

10.1159/000176448

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Citations (2)

[Mitral valve prolapse and sports activity].

PubMed (1988)

C Rusconi P Faggiano Giorgio Orlando Giuseppe Ghizzoni

Mitral valve prolapse

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Citations (0)

Pulmonary Function Tests in Patients with Congestive Heart Failure: Effects of Medical Therapy

Cardiology (1993)

Pompilio Faggiano Carlo Lombardi Alberico Sorgato Giuseppe Ghizzoni C Spedini

In a group of 13 patients with severe heart failure, both forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) significantly improved after intensive medical therapy (FVC: from 77 ± 17 to 92 ± 20%, p < 0.001; FEV1: from 65 ± 15 to 81 ± 15%, p < 0.001) in the absence of change in M-mode echo cardiac dimension and left ventricular systolic function; on the other hand, a change of indices of left ventricular filling by Doppler transmitral flow was documented (E/A ratio: from 3.6 ± 1.2 to 1.65 ± 1.5, p < 0.01; early filling deceleration time: from 94 ± 39 to 178 ± 78 ms, p < 0.01), indicating a reduction of pulmonary capillary pressure; this probably positively affected pulmonary interstitial edema and bronchial wall congestion, thus enhancing pulmonary function.

Vital capacity

Ventricular filling

Pulmonary wedge pressure

10.1159/000175944

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Citations (41)