Magdalena Figlerowicz

Poznan University of Medical Sciences

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Katarzyna Mazur‐Melewska

Poznan University of Medical Sciences

Anna Mania

Poznan University of Medical Sciences

Wojciech Służewski

Poznan University of Medical Sciences

P. Kemnitz

Poznan University of Medical Sciences

Katarzyna Jończyk‐Potoczna

Poznan University of Medical Sciences

Paweł Małecki

Poznan University of Medical Sciences

Arleta Kowala‐Piaskowska

Poznan University of Medical Sciences

Iwona Mozer‐Lisewska

Poznan University of Medical Sciences

Ernest Kuchar

Medical University of Warsaw

Leszek Szenborn

Wroclaw Medical University

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Poznan University of Medical Sciences

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Medical University of Warsaw

Institute of Bioorganic Chemistry, Polish Academy of Sciences

Polish Academy of Sciences

Wroclaw Medical University

Nicolaus Copernicus University

Medical University of Białystok

Medical University of Silesia

Medical University of Lodz

Central Clinical Hospital

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A plant‐derived edible vaccine against hepatitis B virus

The FASEB Journal (1999)

Józef Kapusta A. Modelska Magdalena Figlerowicz Tomasz Pniewski Marie-Claude Letellier

The infectious hepatitis B virus represents 42 nm spherical double-shelled particles. However, analysis of blood from hepatitis B virus carriers revealed the presence of smaller 22 nm particles consisting of a viral envelope surface protein. These particles are highly immunogenic and have been used in the design of hepatitis B virus vaccine produced in yeast. Upon expression in yeast, these proteins form virus-like particles that are used for parenteral immunization. Therefore, the DNA fragment encoding hepatitis B virus surface antigen was introduced into Agrobacterium tumerifacience LBA4404 and used to obtain transgenic lupin (Lupinus luteus L.) and lettuce (Lactuca sativa L.) cv. Burpee Bibb expressing envelope surface protein. Mice that were fed the transgenic lupin tissue developed significant levels of hepatitis B virus-specific antibodies. Human volunteers, fed with transgenic lettuce plants expressing hepatitis B virus surface antigen, developed specific serum-IgG response to plant produced protein.—Kapusta, J., Modelska, A., Figlerowicz, M., Pniewski, T., Letellier, M., Lisowa, O., Yusibov, V., Koprowski, H., Plucienniczak, A., Legocki, A. B. A plant-derived edible vaccine against hepatitis B virus. FASEB J. 13, 1796–1799 (1999)

Hepatitis B vaccine

10.1096/fasebj.13.13.1796

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Citations (381)

Pediatric CIDP: Diagnosis and Management. A Single-Center Experience

Frontiers in Neurology (2021)

Małgorzata Łukawska Anna Potulska‐Chromik Marta Lipowska Dorota Hoffman-Zacharska Beata Olchowik

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare acquired polyneuropathy that especially among youngest children should be differentiated with hereditary neuropathies. Even though upon diagnosis treatment options are similar in children and adults, diagnostic challenges are faced in the pediatric population. Methods: We conducted a retrospective analysis of clinical symptoms, nerve conduction study results, modes of treatment, and final outcome in 37 children aged 3.5–17 years with a final diagnosis of CIDP (18 girls, 19 boys). We established three groups of patients based on age at onset of CIDP: 0–4, 4–13, and 13–18 years. Follow-up ranged from 10 to 222 months. Results: In our analysis, 19/37 patients (51.4%) had an atypical presentation: distal variant of CIDP in 12/37 patients (32.4%) and pure motor variant of CIDP in 5/37 patients (13.5%), and one patient had a pure sensory variant (1/37, 2.7%). Furthermore, 3/37 patients (8.1%) had additional concurring symptoms, including involuntary movements of face muscles (1/37, 2.7%) or hand tremor (2/37, 5.4%). During the follow-up, 23/37 patients (62.2%) received intravenous immunoglobulin (IVIg); 22/37 patients (59.5%) received steroids, 6/37 patients (16.2%) received IVIg and steroids, and 12/37 patients (32.4%) received immunosuppressive drugs, mostly azathioprine, but also methotrexate and rituximab. One patient was treated with plasmapheresis. Complete remission was achieved in 19/37 patients (51.4%) with CIDP in its typical form. Remission with residual symptoms or minimal deficit was observed in 4/37 patients (10.8%), whereas 14/37 patients (37.8%) remain on treatment with gradual improvement. Conclusion: Childhood CIDP may occur in its typical form, but even ~50% of children can present as an atypical variant including distal, pure motor, or pure sensory. Most children have a good prognosis; however, many of them may require long-term treatment. This highlights the importance of an early diagnosis and treatment for childhood CIDP.

Plasmapheresis

Single Center

10.3389/fneur.2021.667378

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Citations (17)

Replikacja HCMV w surowicy krwi i moczu dzieci z cytomegalią wrodzoną

Pediatria Polska (2011)

Magdalena Figlerowicz Anna Mania Katarzyna Mazur‐Melewska P. Kemnitz Marlena Malarowska

10.1016/s0031-3939(11)70002-6

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Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children

Life (2023)

Agnieszka Myszkowska-Torz Magdalena Frydrychowicz Mateusz Tomaszewski Magdalena Figlerowicz Anna Mania

Neuroborreliosis is a form of Lyme Borreliosis (LB) that affects various structures of the central and peripheral nervous system. Although most cases of LB can be cured with a course of antibiotics, some children can present prolonged symptoms, which may constitute post-treatment Lyme disease syndrome (PTLDS). The aim of our analysis was the long-term observation of children with NB and the determination of their risk of PTLDS. The clinical observation was supplemented by a laboratory study based on the assessment of the dynamics of anti-VlsE (variable major protein-like sequence, expressed) IgG antibodies in children with NB after antibiotic therapy. The prospective survey based on 40 children presented 1-2 forms of NB. The control group consisted of 36 patients with analogical symptoms for whom LB was excluded. Our long-term observation showed a low risk of developing long-term complications in children who received antibiotic therapy in accordance with the recommendations. The concentration of anti-VlsE IgG demonstrates a statistical significance for differences between the control and the study groups for each measurement period. Higher values of anti-VlsE IgG were observed in the study group, and the concentration decreased from the first measurement period to the next. The article emphasizes the importance of the long-term follow-up of children with neuroborreliosis.

Neuroborreliosis

Lyme Neuroborreliosis

10.3390/life13040900

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First case of convalescent plasma transfusion in a child with COVID-19-associated severe aplastic anemia

Transfusion and Apheresis Science (2020)

Magdalena Figlerowicz Anna Mania Karol Lubarski Zuzanna Lewandowska Wojciech Służewski

Aplastic anemia

Convalescent plasma

Girl

10.1016/j.transci.2020.102866

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Citations (52)

Corrigendum: Pediatric CIDP: Diagnosis and Management. A Single-Center Experience

Frontiers in Neurology (2022)

Małgorzata Łukawska Anna Potulska‐Chromik Marta Lipowska Dorota Hoffman-Zacharska Beata Olchowik

[This corrects the article DOI: 10.3389/fneur.2021.667378.].

Center (category theory)

10.3389/fneur.2021.784144

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Factors influencing clinical course and histological findings in children with chronic hepatitis B

European Journal of Gastroenterology & Hepatology (2009)

Iwona Mozer‐Lisewska Anna Mania Wojciech Służewski P. Kemnitz Joanna Prusinowska

Although the clinical course of chronic hepatitis B (CHB) is relatively mild in a majority of children, a certain proportion of patients develops chronic liver disease that finally results in serious liver injury. Reports regarding clinical outcome of infection are scarce.The aim of this study was to assess inflammatory activity, fibrosis, and their correlation to clinical data in children with CHB before antiviral treatment.The study included 200 children, aged 1.5-18 years (mean 7.49+/-4.01 years), with CHB hospitalized before liver biopsy between 1992 and 2003. History and clinical data were analyzed. Histopathological assessment was based on the modified Knodell system. Statistical analysis was performed, and results with P<0.05 were considered significant.Necroinflammatory activity was found to be mild in 115 children and moderate in 44. Ninety-three children had minimal fibrosis (S1), 62 children - S2, and the remaining 8 - S3-S4. Alanine aminotransferase (ALT) activity was proportional to staging (Kruskall-Wallis test H=10.84, P=0.028) and was significantly higher in the children with staging >or=S2, P=0.0008. Spontaneous hepatitis B early antigen seroconversion occurred in 30/200 children (15%) and was related to the shorter length of infection, P=0.008.Intensity of liver injury in children with CHB varies from minimal to marked necroinflammatory activity and fibrosis varies from none to advanced. Progression of liver fibrosis seems to be proportional to the age at infection. ALT activity appears to be higher in the children with significant (S2-S4) fibrosis. Spontaneous hepatitis B early antigen seroconversion is apparently related to the shorter length of infection and higher ALT activity.

Seroconversion

Hepatitis B

Liver disease

10.1097/meg.0b013e328317f1fe

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Citations (2)

Cat-scratch disease: a wide spectrum of clinical pictures

Advances in Dermatology and Allergology (2015)

Katarzyna Mazur‐Melewska Anna Mania P. Kemnitz Magdalena Figlerowicz Wojciech Służewski

The aim of this review is to present an emerging zoonotic disease caused by Bartonella henselae. The wide spectrum of diseases connected with these bacteria varies from asymptomatic cases, to skin inflammation, fever of unknown origin, lymphadenopathy, eye disorders, encephalitis and endocarditis. The reservoirs of B. henselae are domestic animals like cats, guinea pigs, rabbits and occasionally dogs. Diagnosis is most often based on a history of exposure to cats and a serologic test with high titres of the immunoglobulin G antibody to B. henselae. Most cases of cat-scratch disease are self-limited and do not require antibiotic treatment. If an antibiotic is chosen, however, azithromycin has been shown to speed recovery.

Cat-scratch disease

Scratch

Broad spectrum

10.5114/pdia.2014.44014

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Citations (89)

Assessment of basic immunological parameters in children with seizure disorders during acute infection

Pediatria i Medycyna Rodzinna (2023)

Grażyna Bugaj Anna Mania Agnieszka Górna Karol Lubarski Katarzyna Mazur‐Melewska

Introduction and objective: The objective of the study was to assess basic immunological parameters in children presenting with seizure disorders during acute infection. Materials and methods: The study was conducted from 19 January 2017 to 5 December 2020 at the Department of Infectious Diseases and Child Neurology in Poznań, and involved 121 patients aged 5–188 months: 64 with febrile seizures and 11 with generalised epilepsy. The control group comprised 46 patients with delayed psychomotor and intellectual development, pervasive developmental disorders, and neurodeficits. A complete blood count with differential white cell count, inflammatory markers, immunoglobulin classes (IgG, IgA, IgM), and the aetiology of infection were analysed using standard laboratory methods in all the cases. Results: Lower IgG was found in the febrile seizures group, and lower IgA was observed in the simple febrile seizure group compared to the patients after epileptic seizures. Patients with first-time simple febrile seizures showed lower IgG levels than the control group. Patients with generalised epilepsy and human herpesvirus 6 (HHV-6) showed lower IgG than the non-infected subjects. Patients with first-time complex febrile seizures had the lowest lymphocyte count compared to the control group. The lowest neutrophil count and total leukocyte count were found in HHV-6-infected patients with simple febrile seizures compared to the non-infected patients. Conclusions: Monitoring basic haematological parameters and immunoglobulin levels is an effective strategy in the diagnosis of seizure disorders in children. Screening tests provide an initial quantitative assessment of humoral and cellular responses, as well as impaired phagocytosis.

Febrile seizure

Etiology

White blood cell

10.15557/pimr.2023.0036

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Citations (1)

Clinical pathology of larval toxocariasis

Advances in Parasitology/Advances in parasitology (2020)

Katarzyna Mazur‐Melewska Anna Mania Wojciech Służewski Magdalena Figlerowicz

Zoonosis

Toxocara cati

10.1016/bs.apar.2020.01.004

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Citations (20)