Background: Helicobacter pylori infection is recognized as an important player in the development of chronic gastritis, peptic ulcers, and gastric carcinoma. The aim of this study was to evaluate the association between H. pylori infection and clinical symptoms in patients referred to a referral academic hospital (Shahid Beheshti hospital). Methods: A total of 303 patients with dyspeptic symptoms underwent endoscopy in the academic hospital. Clinical data were collected for each patient and gastrointestinal symptoms were evaluated by using the Gastrointestinal Symptom Rating Scale Questionnaire. During endoscopy two biopsy specimens were taken from the antrum for histological evaluation. Results: Among the 303 patients, 263 (86.8%) were found to be positive for H. pylori, of whom 43% were male and 57% female. The prevalence of H. pylori infection in patients with anorexia, nausea, heart burn and belching was 98 (32.3%), 89 (29.4%), 132 (43.6%) and 171(56.4%), respectively. Likewise, we found 112 patients with abrupt pain and 46 with pain by consumption of tea were H. pylori-positive. Also 98 (32.3%) patients with a positive family history of gastroduodenal diseases had H. pylori infection. Among them, 20 of 41 patients with a family history of gastric cancers and 50 from 73 with a family history of gastroduodenal ulcers were infected by H. pylori. Conclusion: There was an increased risk of H. pylori infection in 60-69 aged patients (OR = 0.27, 95%CI, 0.086-0.87) compared to young people with aged 20-29. H. pylori was not associated with, marital status, education and ethnic group of the patients (P > 0.05). We found no significant difference in the prevalence of H. pylori infection according to ethnicity (P > 0.05). Also we did not observe any relationship between H. pylori infection and family history. It was observed that some symptoms such as belching, patients with abrupt pain and pain with consumption of tea was significantly associated with H. pylori infection, whereas there was no difference between consumption of other foods and other clinical symptoms. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive
This study was designed to evaluate the frequency of antibody against these viruses in individuals attending the endoscopy ward of Taleghani hospital Tehran, Iran.Blood-borne viruses such as hepatitis B and hepatitis C virus and HTLV-1 virus are among the world's public health problems. Hepatitis viruses cause liver problems and HTLV-1 infection can lead to adult T-Cell lymphoma (ATL).Blood samples of 219 individuals attending the endoscopy ward of Taleghani hospital between years 2009-2011 were collected. A questionnaire containing demographic data was completed for each subject. Blood samples were tested for antibody against HTLV-1, HCV and HBc by ELISA (Dia.pro Italy). In case of positive results for anti-HBc, samples were also tested for HBs Ag antigen.Ninety two subjects were male and 127 were female. Mean age of the population was 39.87 ± 16.47. None of the subjects had anti-HCV antibody, while 4 of them had anti-HTLV-1 antibody and 26 anti-HBc antibody; which only two of these individuals had HBs Antibody.The results of this study show that frequency of anti-HCV and anti-HTLV-1 antibodies are very low, while the frequency of anti-HBc was higher in the population. Since HTLV-1 is the causative agent of a type of blood cancer, it seems that screening of donated bloods in this region should be considered.
eradication rate has been shown following different triple therapies. The present study has for the first time assessed and compared the efficacy of the two 14day PPI-based triple therapies with and without a fluoroquinolone among an Iranian population. Two hundred and seventy patients with peptic ulcer and positive
In this study, we determined the relationship between the serum level of IL-23 and the severity of ulcerative colitis (UC) among our population.A recent major breakthrough for describing the pathogenesis of intestinal tissue injury in inflammatory bowel disease (IBD) is the pathway related to interleukin-23 (IL-23).We performed a prospective case-control study on a total of 85 new patients with ulcerative colitis, recruited from a general referral hospital. Forty ethnically matched healthy controls were also enrolled among hospital staffs and analyzed. Serum IL-23 level was quantified using an electrochemiluminescence immunoassay (ECLIA) method with an immunoassay analyzer.The mean serum IL-23 level in the group with ulcerative colitis was significantly higher than the healthy individuals (347.5±130.8 pg/ml versus 233.5±86.3 pg/ml; p< 0.001). There was a positive correlation between the serum level of IL-23 and disease duration (r = 0.27, p = 0.04). Also, a direct relationship was found between the serum level of IL-23 and the severity of disease (mean IL-23 in mild UC = 296.2±51.2 pg/ml; in moderate UC= 356.1±142.9 pg/ml; and in severe UC= 399.3±163.8 pg/ml, p = 0.04).Serum level of IL-23 is directly correlated with the duration and severity of ulcerative colitis.
The use of vitamin C as a supplement with the common regimen for eradication of Helicobacter pylori infection is the subject of ongoing controversy. We conducted a prospective controlled study with the aim of testing whether the vitamin C supplement to the therapy includes lower dosage of clarithromycin could have an acceptable influence on Helicobacter pylori eradication in comparison with routine anti-Helicobacter pylori regimen.Two hundred and fourteen consecutive patients with the verification of Helicobacter pylori infection via positive Rapid Urease Test (RUT) and histology results were included and divided into two therapy groups: 1) a group without vitamin C (n = 100) that were administered 20 mg omeprazol, 1 g amoxicillin, and 500 mg clarithromycin twice daily for 2 weeks and 2) a triple-plus-vitamin C group (n = 114) that was administered 20 mg omeprazol, 1 g amoxicillin, 250 mg clarithromycin plus 250 mg vitamin C twice daily for 2 weeks. Four weeks after the completion of therapy, each patient was scheduled for urea breath test to assess the success of Helicobacter pylori eradication.Similar eradication of Helicobacter pylori was found between the triple-only group with 500 mg of clarithromycin and the triple with 250 mg of clarithromycin-plus vitamin C group (89% versus 86.8%, P = 0.623).Adding vitamin C might reduce the needed dosage of clarithromycin for eradication of Helicobacter pylori.
Pancreatitis remains the most common complication of endoscopic retrograde cholangiopancreatography (ERCP), resulting in substantial morbidity and occasional mortality. There are notable controversies and conflicting reports about risk factors of post-ERCP pancreatitis (PEP).To evaluate the potential risk factors for PEP at a referral tertiary center, as a sample of the Iranian population.Baseline characteristics and clinical as well as paraclinical information of 780 patients undergoing diagnostic and therapeutic ERCP at Taleghani hospital in Tehran between 2008 and 2012 were reviewed. Data were collected prior to the ERCP, at the time of the procedure, and 24-72 hours after discharge. PEP was diagnosed according to consensus criteria.Of the 780 patients who underwent diagnostic ERCP, pancreatitis developed in 26 patients (3.3%). In the multivariable risk model, significant risk factors with adjusted odds ratios (ORs) were age <65 years (OR = 10.647, P = 0.023) and erythrocyte sedimentation rate (ESR) >30 (OR = 6.414, P < 0.001). Female gender, history of recurrent pancreatitis, pre-ERCP hyperamylasemia, and difficult or failed cannulation could not predict PEP. There was no significant difference in the rate of PEP in wire-guided cannulation versus biliary cannulation using a sphincterotome and contrast injection as the conventional method.Performing ERCP may be safer in the elderly. Patients with high ESR may be at greater risk of PEP, which warrants close observation of these patients for signs of pancreatitis after ERCP.
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