Jinjian Zheng

The First Affiliated Hospital, Sun Yat-sen University

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Vijay Kumar

Johns Hopkins Medicine

Dayu Pan

First Affiliated Hospital of Jiangxi Medical College

Mei Wan

Johns Hopkins University

Junying Zheng

Johns Hopkins University

Xuequan Han

Johns Hopkins University

Xu Cao

Johns Hopkins University

Kheiria Gamal Benkato

Johns Hopkins Medicine

Junyong Kang

Xiamen University

Xiaoyi Gong

Merck & Co., Inc., Rahway, NJ, USA (United States)

Edward S. Yeung

Merck & Co., Inc., Rahway, NJ, USA (United States)

Cooperative Institutions

Sun Yat-sen University

Merck & Co., Inc., Rahway, NJ, USA (United States)

The First Affiliated Hospital, Sun Yat-sen University

Xiamen University

Chinese Academy of Sciences

University of Science and Technology of China

Xiamen University of Technology

Huazhong University of Science and Technology

Tsinghua University

Key Laboratory of Guangdong Province

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Current challenges and future prospects in chromatographic method development for pharmaceutical research

TrAC Trends in Analytical Chemistry (2017)

Frederick T. Mattrey Alexey A. Makarov Erik L. Regalado Frank Bernardoni Margaret Figus

Pharmaceutical Sciences

10.1016/j.trac.2017.07.021

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Citations (117)

Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions

JOR Spine (2025)

Wentian Li Ji Tu Jinjian Zheng Abhirup Das Yan Qi

Chronic low back pain (LBP) is a significant global health concern, often linked to vertebral bone marrow lesions (BML), particularly fatty replacement (FR). This study aims to explore the relationship between the gut microbiome, serum metabolome, and FR in chronic LBP patients. Serum metabolomic profiling and gut microbiome analysis were conducted in chronic LBP patients with and without FR (LBP + FR, n = 40; LBP, n = 40) and Healthy Controls (HC, n = 31). The study investigates alterations in branched-chain amino acids (BCAAs) levels and identifies key microbial species associated with BCAA metabolism. In vitro experiments elucidate the role of BCAAs in adipogenesis of bone marrow mesenchymal stem cells (BM-MSCs) via the SIRT4 pathway. Chronic LBP patients with FR exhibit depleted BCAA levels in their serum metabolome, along with alterations in the gut microbiome. Specific microbial species, including Ruminococcus gnavus, Roseburia hominis, and Lachnospiraceae bacterium 8 1 57FAA, are identified as influential in BCAA metabolism and BM-MSCs metabolism. In vitro experiments demonstrate the ability of BCAAs to induce BM-MSCs adipogenesis through SIRT4 pathway activation. This study sheds light on the intricate relationship between the disturbed gut ecosystem, serum metabolites, and FR in chronic LBP. Dysbiosis in the gut microbiome may contribute to altered BCAA degradation, subsequently promoting BM-MSCs adipogenesis and FR. Understanding these interactions provides insights for targeted therapeutic strategies to mitigate chronic LBP associated with FR by restoring gut microbial balance and modulating serum metabolite profiles.

Metabolome

Dysbiosis

10.1002/jsp2.70042

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ZnO/ZnSe Type II Core-Shell Nanowire Array Solar Cell

MRS Proceedings (2012)

Yufeng Zhang D. Li Zhiming Wu Jinjian Zheng Xianwu Lin

Hybrid solar cell

10.1557/opl.2012.436

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Reviewer #2 (Public Review): Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Dayu Pan Kheiria Gamal Benkato Xuequan Han Jinjian Zheng Vijay Kumar

Spinal pain affects individuals of all ages and is the most common musculoskeletal problem globally. Its clinical management remains a challenge as the underlying mechanisms leading to it are still unclear. Here, we report that significantly increased numbers of senescent osteoclasts (SnOCs) are observed in mouse models of spinal hypersensitivity, like lumbar spine instability (LSI) or aging, compared to controls. The larger population of SnOCs is associated with induced sensory nerve innervation, as well as the growth of H-type vessels, in the porous endplate. We show that deletion of senescent cells by administration of the senolytic drug Navitoclax (ABT263) results in significantly less spinal hypersensitivity, spinal degeneration, porosity of the endplate, sensory nerve innervation and H-type vessel growth in the endplate. We also show that there is significantly increased SnOC-mediated secretion of Netrin-1 and NGF, two well-established sensory nerve growth factors, compared to non-senescent OCs. These findings suggest that pharmacological elimination of SnOCs may be a potent therapy to treat spinal pain.

Senescence

10.7554/elife.92889.2.sa1

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Reviewer #1 (Public Review): Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Dayu Pan Kheiria Gamal Benkato Xuequan Han Jinjian Zheng Vijay Kumar

Senescence

10.7554/elife.92889.2.sa2

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Anomalous Radial Migration of Single DNA Molecules in Capillary Electrophoresis

Analytical Chemistry (2002)

Jinjian Zheng Edward S. Yeung

We report the unexpected radial migration of DNA molecules in capillary electrophoresis (CE) with applied Poiseuille flow. Such movement can contribute to anomalous migration times, peak dispersion, and size and shape selectivity in CE. When Poiseuille flow is applied from the cathode to the anode, DNA molecules move toward the center of the capillary, forming a narrow, highly concentrated zone. Conversely, when the flow is applied from the anode to the cathode, DNA molecules move toward the walls, leaving a DNA-depleted zone around the axis. We showed that the deformation and orientation of DNA molecules under Poiseuille flow was responsible for the radial migration. By analyzing the forces acting on the deformed and oriented DNA molecules, we derived an expression for the radial lift force, which explained our results very well under different conditions with Poiseuille flow only, electrophoresis only, and the combination of Poiseuille flow and electrophoresis. Factors governing the direction and velocity of radial migration were elucidated. Potential applications of this phenomenon include an alternative to sheath flow in flow cytometry, improving precision and reliability of single-molecule detection, reduction of wall adsorption, and size separation with a mechanism akin to field-flow fractionation. On the negative side, nonuniform electroosmotic flow along the capillary or microfluidic channel is common in CE, and radial migration of certain analytes cannot be neglected.

Hagen–Poiseuille equation

Electro-osmosis

10.1021/ac0257344

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Citations (69)

Thinking outside of the box: Designing a simple solution to quantitate a mutagenic impurity in a complex matrix

Laura Pfund Jinjian Zheng

Macromolecular Chemistry: The Second Century [Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing) [How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf) [Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

Matrix (chemical analysis)

Complex matrix

10.1021/scimeetings.0c03230

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Gallium nitride blue laser diodes with pulsed current operation exceeding 15 W in optical output power

Journal of Semiconductors (2024)

Shuiqing Li Qiangqiang Guo Hui Deng Zhibai Zhong Jinjian Zheng

Blue laser

Laser diode

10.1088/1674-4926/24080031

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Fabrication of High‐Voltage Flip Chip Deep Ultraviolet Light‐Emitting Diodes Using an Inclined Sidewalls Structure

physica status solidi (a) (2019)

Zhibai Zhong Xuanli Zheng Jinchai Li Jinjian Zheng Yashu Zang

Two types of high‐voltage flip chip deep ultraviolet light emitting diodes (HV‐FC DUV‐LEDs) are constructed with 2 × 2 and 3 × 3 cells, respectively, in which each single cell is fabricated with inclined sidewalls covered by SiO 2 /Al. The simulation results suggest that the structure with inclined sidewalls is much favorable to extract the transverse magnetic‐polarized lights. As a result, the light power as high as 145.7 mW is achieved in HV‐FC DUV‐LED constructed with 3 × 3 cells at 1000 mA.

Ultraviolet

Ultraviolet light

10.1002/pssa.201900059

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Acetylshikonin promoting PI3K/Akt pathway and inhibiting SOX4 expression to delay intervertebral disc degeneration and low back pain

Journal of Orthopaedic Research® (2023)

Yuming Huang Linchuan Lei Zhuoyang Zhao Zemin Li Hua Wang

This study investigated the molecular mechanism by which acetylshikonin inhibits SOX4 expression via the PI3K/Akt pathway to delay intervertebral disc degeneration (IVDD) and low back pain (LBP). Bulk RNA-seq, RT-qPCR, Western blot analysis, immunohistochemical staining, small interfering RNA (siSOX4), lentivirus (lentiv-SOX4

SOX4

10.1002/jor.25653

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