Jin Jiao

Shandong First Medical University

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Chengjie Duan

China General Nuclear Power Corporation (China)

Yang Xiang

East China University of Science and Technology

Shuo Xu

Tsinghua University

Xiaoqiang Li

Lanzhou University of Technology

Wenting Cheng

Sichuan University

Yan Chen

Qingdao Binhai University

Gangyin Luo

Suzhou Institute of Biomedical Engineering and Technology

Jianwei Jiao

Chinese Academy of Sciences

Yanheng Yao

Nanjing University

Xiaoyi Ma

Northwest A&F University

Cooperative Institutions

Nanjing University

Chinese Academy of Sciences

Shandong First Medical University

Shandong Tumor Hospital

Suzhou Institute of Biomedical Engineering and Technology

University of Science and Technology of China

Central South University

Yantai University

University of Chinese Academy of Sciences

Tsinghua University

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DNA-functionalized gold nanoparticles: Modification, characterization, and biomedical applications

Frontiers in Chemistry (2022)

Xiaoyi Ma Xiaoqiang Li Gangyin Luo Jin Jiao

With the development of technologies based on gold nanoparticles (AuNPs), bare AuNPs cannot meet the increasing requirements of biomedical applications. Modifications with different functional ligands are usually needed. DNA is not only the main genetic material, but also a good biological material, which has excellent biocompatibility, facile design, and accurate identification. DNA is a perfect ligand candidate for AuNPs, which can make up for the shortcoming of bare AuNPs. DNA-modified AuNPs (DNA-AuNPs) have exciting features and bright prospects in many fields, which have been intensively investigated in the past decade. In this review, we summarize the various approaches for the immobilization of DNA strands on the surface of AuNPs. Representative studies for biomedical applications based on DNA-AuNPs are also discussed. Finally, we present the challenges and future directions.

Biocompatibility

Characterization

Surface Modification

10.3389/fchem.2022.1095488

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Citations (22)

Assembly of DNA triangular pyramid frustum for ultrasensitive quantification of exosomal miRNA

Biosensors and Bioelectronics (2023)

Renpeng Xia Hua Chai Jin Jiao Peng Miao

Multiple displacement amplification

Pyramid (geometry)

10.1016/j.bios.2023.115297

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Citations (12)

Self-consuming DNA nanogear retrieval exosomes for grading analysis of gliomas

Chemical Engineering Journal (2024)

Shuo Xu Lie Li Noshin Afshan Gang Wang Miaoqing Zhao

Aptamer

Exosome

Grading (engineering)

10.1016/j.cej.2024.150143

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Highly Sensitive Aptasensor for Detecting Cancerous Exosomes Based on Clover-like Gold Nanoclusters

Analytical Chemistry (2022)

Wenting Cheng Chengjie Duan Yan Chen Dayong Li Zhiqiang Hou

Exosome-based liquid biopsy technologies play an increasingly prominent role in tumor diagnosis. However, the simple and sensitive method for counting exosomes still faces considerable challenges. In this work, the CD63 aptamer-modified DNA tetrahedrons on the gold electrode were used as recognition elements for the specific capture of exosomes. Partially complementary DNA probes act as bridges linking trapped exosomes and three AuNP-DNA signal probes. This clover-like structure can tackle the recognition and sensitivity issues arising from the undesired AuNP aggregation event. When cancerous exosomes are present in the system, the high accumulation of methylene blue molecules from DNA-AuNP nanocomposites on the surface of the electrode leads to an intense current signal. According to the results, the aptasensor responds to MCF-7 cell-derived exosomes in the concentration range from 1.0 × 103 to 1.0 × 108 particles·μL-1, with the detection limit of 158 particles·μL-1. Furthermore, the aptasensor has been extended to serum samples from breast cancer patients and exhibited excellent specificity. To sum it up, the aptasensor is sensitive, straightforward, less expensive, and fully capable of receiving widespread application in clinics for tumor monitoring.

Aptamer

Nanoclusters

Exosome

Liquid biopsy

Methylene blue

CD63

10.1021/acs.analchem.2c04280

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Citations (16)

Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA–RNA building blocks for the multi-analysis of miRNAs

Journal of Materials Chemistry B (2023)

Chengjie Duan Yan Chen Zhiqiang Hou Dayong Li Jin Jiao

Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA–RNA building blocks for the multi-analysis of miRNAs.

10.1039/d2tb02663e

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Citations (1)