W Meier

Evangelisches Krankenhaus Düsseldorf

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Holger Hertzberg

Stadtkrankenhaus Schwabach

Thorsten Langer

University of Freiburg

Jörn D. Beck

Friedrich-Alexander-Universität Erlangen-Nürnberg

W. Huk

Friedrich-Alexander-Universität Erlangen-Nürnberg

Michael A. Überall

Leibniz Institute for Neurobiology

Michael A. Ueberall

Institute of Neurological Sciences

D. Wénzel

Michigan Medicine

Sven� Mahner

Ludwig-Maximilians-Universität München

K. Berger-Jones

Friedrich Schiller University Jena

U. Finsterer

Ludwig-Maximilians-Universität München

Cooperative Institutions

Klinik für Frauenheilkunde

Klinik und Poliklinik für Kinder- und Jugendmedizin

Arbeitsgemeinschaft Gynäkologische Onkologie Studiengruppe

Charité - Universitätsmedizin Berlin

Friedrich-Alexander-Universität Erlangen-Nürnberg

Heidelberg University

Olgahospital

Heinrich Heine University Düsseldorf

Ludwig-Maximilians-Universität München

Universitätsklinikum Erlangen

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Visual-Evoked Potentials in Long-Term Survivors of Acute Lymphoblastic Leukemia in Childhood

Neuropediatrics (1996)

Michael A. Überall H. Hertzberg W Meier Thorsten Langer Jörn‐Dirk Beck

Visual-evoked potentials (VEPs) were studied in 92 asymptomatic long-term survivors of acute lymphoblastic leukemia (ALL) in first complete remission 6-7 years after cessation of therapy in order to detect therapy-related disturbances in conduction velocity capacities within central nerve fibers. Subjects were grouped with respect to CNS prophylaxis: a) ith. MTX and 18 Gy cranial irradiation (group A, n = 58), b) ith. MTX and iv. MHD-MTX, no cranial irradiation (group B, n = 34). At follow-up VEPs were abnormal in 10 subjects (10.9 %) with comparable rates in both CNS prophylaxis groups (A: 7/58 [12.1 %], B: 3/34 [8.8 %]; p = 0.56). Participants with radiological signs of leukodystrophy (n = 14), all within the irradiated CNS prophylaxis group, showed significantly prolonged P100 latencies and had a 6.1-fold increased relative risk to develop VEP disturbances. No correlation could be established between VEP outcome and illness- or treatment-related parameters. VEP outcome was not correlated with age at diagnosis or gender. Thus, VEP recordings showed a close relationship with radiation-induced CNS white-matter disturbances. However, their value for clinical practice, routinely performed follow-up evaluations or standardized posttreatment surveillance studies is negligible.

10.1055/s-2007-973786

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Citations (16)

Lokaler Resektionsrand und Rezidivrisiko beim Plattenepithelkarzinom der Vulva – Ergebnisse einer Subgruppenanalyse der multizentrischen AGO CaRE-1 Studie

Geburtshilfe und Frauenheilkunde (2014)

Linn Woelber Jens Kosse C Heiss Petra Neuser Peer Hantschmann

Fragestellung: Diese Subgruppenanalyse der AGO-CaRE-1 Studie untersucht den Einfluss des pathologischen Resektionsrandes auf das Rezidivrisiko beim Vulvakarzinom. Hintergrund ist die Infragestellung des derzeitigen Standards von 8 mm durch kleinere Fallserien.

10.1055/s-0034-1388596

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Citations (0)

[Changes in plasma zinc under anesthesia and surgery (author's transl)].

PubMed (1981)

U. Finsterer S Kapser W Meier E Reiser-Zimre Edgar Fischer

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P300 Abnormalities in Long-Time Survivors of Acute Lymphoblastic Leukemia in Childhood - Side Effects of CNS Prophylaxis?

Neuropediatrics (1996)

Michael A. Überall Karin Haupt W Meier Holger Hertzberg James F. Beck

The incidence and the degree of P300 abnormalities in relation to psychometric findings was assessed in two groups of long-term survivors of acute lymphoblastic leukemia (ALL) in childhood. The study was performed as part of a follow-up trial, evaluating CNS late-effects after antileukemic therapy, 7.1 +/- 1.6 years after cessation of antileukemic therapy. Subject groups differed primarily in terms of antileukemic CNS prophylaxis: combined radio- and chemotherapy (n = 8) vs. chemotherapy alone (n = 5). Results were compared with those of a third group of healthy controls (n = 13) matched for age and gender. P300 recordings were obtained during a visual oddball-paradigm using checkerboard reversal stimuli of different pattern sizes as target and background events. Neurophysiological data were correlated with the results of a psychological test battery, which measured general intelligence, non-verbal visual memory functioning and concentration. ERP analysis showed a significant prolongation of the P300 latency in irradiated subjects when compared to healthy controls and non-irradiated long-term survivors. Topographical data comparisons revealed substantial P300 differences in both ALL long-term survivor groups when compared with healthy controls. This demonstrated significantly lower amplitudes over the left frontal derivations, associated with lowered concentration abilities, in the irradiated subject group. Higher amplitudes over the parieto-temporal derivations of the right hemisphere, associated with significantly impaired visual memory capabilities, were seen in both long-term survivor groups.

Childhood leukemia

10.1055/s-2007-973763

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Citations (19)

Die Nachsorge der von einer Krebserkrankung geheilten Kinder und jungen Erwachsenen. Erste Empfehlungen der Arbeitsgemeinschaft Spätfolgen

Klinische Pädiatrie (1995)

Jörn‐Dirk Beck Kurt Winkler D. Niethammer M. Brandis Holger Hertzberg

An increasing number of children suffering from cancer has been treated successfully during the last 25 years using therapy protocols of the Gesellschaft für Pädiatrische Onkologie und Hämatologie. The patients had to undergo an interdisciplinary treatment modality and a mostly intensive chemotherapy. Late effects could result from this approach for the now 20,000 survivors in the Federal Republik of Germany. The executive committee of the GPOH founded a working group for the detection of late effects stretching over all therapy studies. The first report of this group describes a spectrum of relevant late effects and proposes investigations for their detection.

10.1055/s-2008-1046537

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Citations (31)

[Behavior of prothrombin, proconvertin, proaccelerin, fibrinogen and heparin tolerance test in newborn and infants in first year of life].

PubMed (1957)

M. Vest W Meier

Afibrinogenemia

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Citations (4)

Disease Progression in female Patients with borderline ovarian Tumors: Results of the multicentric AGO ROBOT Study

Barbara Schmalfeldt Alexander Burges Felix Hilpert Alexander Reuß Tanja Fehm

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CNS late effects after ALL therapy in childhood. Part I: Neuroradiological findings in long-term survivors of childhood ALL—an evaluation of the interferences between morphology and neuropsychological performance

Medical and Pediatric Oncology (1997)

Holger Hertzberg W. Huk Michael A. Ueberall Thorsten Langer W Meier

The effect of cranial irradiation on possible therapy-induced morphological central nervous system (CNS) side effects of children cured from acute lymphoblastic leukemia (ALL) is controversially discussed. In a retrospective multicenter study, 118 former ALL patients in first continous remission were investigated using cranial computerised tomography (CCT) or magnetic resonance imaging (MRI) scans to evaluate CNS related impairments. Corresponding to the different kinds of CNS prophylaxis, the patient sample was divided: group A (n = 39) receiving intrathecal methotrexate (ITMTX) and systemical medium-high-dose methotrexate (SMHDMTX), group B (n = 41) cranial irradiated (in mean 16.8 Gy) and administering ITMTX and SMHDMTX, group C (n = 38) irradiated (in mean 17.1 Gy) and getting ITMTX. Pathologic scans showed atrophy, leukoencephalopathy, calcifications or grey matter changes. These findings were compared with the neuropsychological test results. Abnormal MRI or CCT scans were found in 61/118 patients (51.7%). Fifteen belonged to group A (38.5%), 23 to B (56.1%) and 23 to C (60.5%). Patients with definite CNS changes show reduced neuropsychological test results. The prevalence of brain alterations seems to appear twice increased after lengthening the post-therapeutic interval in irradiated patients as in nonirradiated patients. Irradiated patients with an age younger than 2 years at diagnosis may show a lower prevalence for developing CNS alterations. CNS alterations are not sex-related. Children treated with cranial irradiation in combination with SMHDMTX and/or ITMTX were at greater risk of developing morphological brain alterations than patients with chemotherapy alone. These alterations are partly correlated with reduced neuropsychological performances and seem to stay with a longer post-therapeutic interval. Med. Pediatr. Oncol. 28: 387–400, 1997. © 1997 Wiley-Liss, Inc.

Late childhood

10.1002/(sici)1096-911x(199706)28:6<387::aid-mpo1>3.0.co;2-c

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Citations (116)

Quantitative EEG in long-term survivors of acute lymphoblastic leukemia

Pediatric Neurology (1996)

Michael A. Ueberall Karin Haupt Holger Hertzberg Thorsten Langer W Meier

Acute lymphocytic leukemia

Spectral Analysis

10.1016/s0887-8994(96)00232-9

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Citations (10)