K Nakamura

Hyogo Prefectural Cancer Center

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Kikuo Mori

The Japanese Society of Intensive Care Medicine

Masahiro Ochiai

Niigata University

H. Yamaguchi

Southern Tohoku General Hospital

Hiroki Imazu

Nagoya University

Yoshihisa Marugami

Fujita Health University

Hiroshi Fukui

University Hospital Kyoto Prefectural University of Medicine

Kazufumi Arai

Tottori University Hospital

Toshihiko Tanaka

Yamaguchi University

Tatsuya Kanuma

Hyogo Prefectural Cancer Center

Katsuhiko Kamei

Chiba University Hospital

Cooperative Institutions

Fujita Health University

The University of Tokyo

Fujita Health University Hospital

Gunma University

Hyogo Prefectural Cancer Center

Osaka University

University of Tsukuba

Niigata University

Kindai University

Nagoya University

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CLONAL PROLIFERATION OF AH66 RAT HEPATOMA-CELLS IN RESPECT OF AFP PRODUCTION AS DETERMINED BY AN IMMUNOHISTOCHEMICAL TECHNIQUE

Hiroki Hirai K Nakamura Yasukatsu Tsukada Bischof Wkd

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Growing process to carcinoma of linitis plastica type of the stomach from cancer development

K Nakamura Yoshiaki Kato Toshiaki Misono Hiroshi Sugano Noriyoshi Sugiyama

Linitis plastica

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Citations (8)

Des-gamma-carboxy prothrombin (PIVKA-II) and alpha-fetoprotein-producing IIc-type early gastric cancer.

PubMed (1992)

Masatoshi Kudo Yoshikazu Takamine K Nakamura H. Shirane Hiroyuki Uchida

We describe the case of a 56-yr-old man with primary gastric adenocarcinoma, who had an extremely high plasma level of des-gamma-carboxy prothrombin (2.45 AU/ml) and of serum alpha-fetoprotein (2810 ng/ml). Histopathologically, the gastric cancer was a IIc type of early cancer which consisted of a combination of a poorly differentiated adenocarcinoma and a well-differentiated tubular adenocarcinoma. The association of a hepatic tumor including hepatocellular carcinoma or liver metastasis was ruled out by ultrasonography, computed tomography, radiocolloid liver scan, magnetic resonance imaging, and angiography. Foci strongly resembling hepatocellular carcinoma (hepatoid differentiation) were noted in the gastric tumor. Localization of des-gamma-carboxy prothrombin and alpha-fetoprotein within the tumor cells, especially within the hepatoid differentiated foci, was demonstrated by the immunohistochemical staining of tissue obtained at biopsy and the resected specimen. This case seems to be the first case reported in which des-gamma-carboxy prothrombin was produced by the gastric cancer. This finding supports the theory of hepatoid differentiation of a gastric cancer.

Alpha-fetoprotein

Liver Cancer

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[Preoperative estimation of lymph node metastases in esophageal cancer--correlation between numbers of desmosomes and the lymph node metastases].

PubMed (1987)

Toru Koyama Masamichi Matsumori H Yoshihara A Sasada K Nakamura

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[A case of superficial squamous cell carcinoma of the esophagus showing multicentric development].

PubMed (1989)

Yukiya Saitoh Shoichi Koyama Sai S Tadashi Ebihara Yoshiaki Takase

A 43-year-old male was admitted to the hospital with a complaint of mild dysphagia. A barium esophagogram showed an annular narrowing in the lower esophagus. Further, an endoscopic examination revealed erosive mucosa of the esophagus about 35 cm anal to the incisor. Lugol staining also revealed a geographical unstained lesion. The histologic diagnosis of a biopsy specimen indicated a squamous cell carcinoma and a total resection of the esophagus was performed. The operated material macroscopically showed a tumor of a superficially mixed type (IIa + IIc + IIb). The resected specimen histologically consisted of 18 squamous carcinomas that were separated with the normal squamous epithelium from each other. The major part of these lesions were limited to the epithelium, and only a few specimens microscopically showed an invasion of cancer nests in the propria mucosae. Great permeation of cancer cells into lymph vessels and the metastasis of one regional lymph node also were noted. Taken together, these findings indicated that the squamous cell carcinomas of this case seemed to have multicentrically developed from the normal esophageal mucosa.

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A STUDY OF DNA PLOIDY PATTERN, PROLIFERAION INDEX AND PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN PRIMARY AND METASTATIC TUMORS IN ADVANCED GASTRIC CARCINOMA

The journal of the Japanese Practical Surgeon Society (1993)

Hiroki Imazu Takahiko Funabiki Masahiro Ochiai Yoshihisa Marugami K Nakamura

Fifth-five materials including primary lesions and lymph node metastasis from 15 cases of advanced gastric carcinoma were evaluated for DNA ploidy patterns, proliferation index (PI), proliferating cell nuclear antigen (PCNA). 1) DNA aneuploidy pattern was found in 43 out of 55 materials (78%). 2) Heterogeneity on DNA histogram was observed in 8 cases (53%). 3) PCNA staining was positive in 53 materials (96%). 4) DNA ploidy pattern was revealed to correlate significantly to PI (p<0.05) and PCNA positive rate (p<0.005). 5) PI was revealed to correlate significantly (p<0.05, rS=0.345) to PCNA positive rate. 6) Fixation time did not effect in PCNA staining rate at least within 2 weeks. 7) No correlation of DNA ploidy pattern, PI, or PCNA positive rate to n-number (metastasis to distant lymph node) could be detected. From these findings, no correlation between probable distant lymph node metastasis and the degree of malignanicy and proliferating activity due to these parameters were able to be proved. For this, possible participation of heterogeneity can be inferred.

Nuclear DNA

10.3919/ringe1963.54.2962

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Glucose Metabolism in Renal Stone Patients

Urologia Internationalis (1993)

Masanori Iguchi Tohru Umekawa Chisato Takamura Itsuroh Sugihara K Nakamura

The calciuric response and the changes of plasma glucose and insulin produced by a 75-gram oral glucose tolerance test were determined in 27 male patients with idiopathic calcium renal stones (6 with dietary hypercalciuria, 5 with nondietary hypercalciuria and 16 with normocalciuria) and 22 healthy male subjects. The subjects were classified as obese (≧ 120% ideal weight) and nonobese. The incidence of an abnormal response to glucose loading was similar in the stone patients and the healthy subjects. In addition, the plasma glucose and insulin levels after oral glucose load did not differ between the stone patients and control subjects and were affected by the individual degree of obesity. Urinary calcium excretion increased significantly after glucose ingestion in both the stone patients and the control subjects. Urinary calcium excretion was greater in the stone patients than in the control subjects due to the presence of patients with nondietary hypercalciuria, and the increment in urinary calcium excretion in the dietary hypercalciuric and normocalciuric stone patients was indistinguishable from that in the control subjects. The degree of obesity did not affect the increment in urinary calcium excretion. These results suggest that overconsumption of refined carbohydrates such as sugar-sweetened soft drinks, soda and cakes may be a risk factor for stone formation, especially in the patients with nondietary hypercalciuria.

Urinary calcium

10.1159/000282542

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Citations (20)

[Primary adenocarcinoma of the esophagus arising from heterotopic gastric glands].

PubMed (1970)

G Sakamoto K Nakamura Koichi Saito Mutsuya Sato Toshio Sugahara

Primary (astronomy)

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Jejunal Interposition as a Reconstruction for Radical Distal Gastrectomy.

The Japanese Journal of Gastroenterological Surgery (1993)

Takahiko Funabiki Masahiro Ochiai Hiroshi Amano H. Yamaguchi Yoshihisa Marugami

郭清度および再建術式と術後quality of lifeとの関連を検討した.幽門側胃癌で,(1) 噴門全周を含むR3あるいはこれに準ずる郭清+胃亜全摘+空腸間置をA群,(2) 同様な郭清, 切除+Billroth-I法をB群,(3) 非郭清あるいはR1郭清+普通切除+Billroth-I法をC群とし3者間で比較検討した.術後の内視鏡検査における残胃内胆汁逆流および残胃炎所見はA群ではいずれも認めず, B群ではそれぞれ52.6% (10/19), 57.9% (11/19), C群では33.3% (5/15), 46.7% (7/15) でありA群とB, C群とで差を認めた.逆流性食道炎所見はA, C群では1例もなくB群で21.1% (4/19) と高かった.計測上のHis角はA, B, C群でそれぞれ97°, 133°, 105°でA群で狭かった.シンチグラムでのRIの残胃内逆流はA群8.3% (1/12), B群40.0% (4/10) とA群が少なく, またLES圧はA群13.5cmH2O, B群11.8cmH2OとA群でやや高かった.体重減少率, 食道炎症状, ダンピング症候群の発生率はいずれもB群において最も高かった.

Billroth I

10.5833/jjgs.26.26

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Enhancement of mast cell proliferation by conditioned medium of mouse skin SCC cell line on normal skin fibroblasts

Journal of Dermatological Science (1990)

Toshihiko Tanaka K Nakamura Shoso Yamamoto

10.1016/0923-1811(90)90613-i

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