Isabella Theresa Felzer-Kim

Michigan State University

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i-10 index

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Co-Authors

Janet Hauck

Michigan State University

Ajit P. Joglekar

University of Michigan–Ann Arbor

Pavithra Aravamudhan

University of Pittsburgh

Zakia Alavi

Michigan State University

Chelsea Adkins

Michigan State University

William F. Harrington

Broad Institute

Mengyang Sun

Jacobi Medical Center

Lejla Cesko

Calvin University

Jesse Hendriksma

Calvin University

Jeremy Buhler

Washington University in St. Louis

Cooperative Institutions

Washington University in St. Louis

Albion College

University of Puerto Rico-Mayaguez

Calvin University

California State University, Stanislaus

Missouri Western State University

California Polytechnic State University

Duke University

McDaniel College

St. Edward's University

Author Statistics

Papers

Citation

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Early Movement Matters: Interplay of Physical Activity and Motor Skill Development in Infants With Down Syndrome

Adapted Physical Activity Quarterly (2020)

Janet Hauck Isabella Theresa Felzer-Kim Kathryn L. Gwizdala

This longitudinal study investigated monthly motor development and physical activity (PA) of infants with and without Down syndrome. Gross and fine motor skills (Bayley Scales of Infant Development-III) and PA (accelerometer) were assessed in 35 infants at eight time points during infancy. A multivariate mixed model identified time points when motor scores diverged between the groups. In infants with Down syndrome, bivariate correlations between monthly PA and motor changes were calculated, and multivariate analysis of variance probed the influence of early PA on motor-skill timing. Results indicate that differences in gross and fine motor skills first emerge at 2 and 4 months, respectively. In infants with Down syndrome, gross motor and PA changes between 4 and 6 months were positively correlated. Infants more active than the mean at 2 or 3 months achieved several prone and sitting skills earlier. These results highlight the adaptability of early infancy and the importance of early intervention.

Gross motor skill

Motor Behavior

Typically developing

Sitting

10.1123/apaq.2019-0012

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Citations (12)

How Much Instructional Time Is Necessary? Mid-intervention Results of Fundamental Movement Skills Training Within ABA Early Intervention Centers

Frontiers in Integrative Neuroscience (2020)

Isabella Theresa Felzer-Kim Janet Hauck

Background: The purpose of this study was to explore the question of the minimal amount of instructional time needed to still be effective by assessing the efficacy at mid-intervention of an early fundamental movement skill (FMS) intervention for preschoolers with Autism Spectrum Disorder (ASD). Method: Fourteen preschoolers participated in this randomized controlled trial daily over 10 weeks (10 h total at mid-intervention). A two-factor mixed MANOVA tested the significance of group*time interactions for two dependent variables: object control and locomotor raw scores on the Test of Gross Motor Development-III. Results: Group*time interactions approached significance with large effect sizes on the vector of both dependent variables and in a univariate fashion on object control scores, but not locomotor scores. Conclusions: These findings hold relevance for physical educators working with young children with ASD, indicating that 10 h of FMS instruction, at least in this form, is not adequate to improve FMS.

Univariate

Gross motor skill

10.3389/fnint.2020.00024

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Citations (10)

Assembling the Protein Architecture of the Budding Yeast Kinetochore-Microtubule Attachment using FRET

Current Biology (2014)

Pavithra Aravamudhan Isabella Theresa Felzer-Kim Kaushik Gurunathan Ajit P. Joglekar

10.1016/j.cub.2014.05.014

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Citations (67)

Implementing COVID-19 Mitigation in the Community Mental Health Setting: March 2020 and Lessons Learned

Community Mental Health Journal (2020)

Zakia Alavi Raza Haque Isabella Theresa Felzer-Kim Todd Lewicki Ali Abrar Al Haque

In March 2020, at the beginning of the COVID-19 pandemic, state-funded community mental health service programs (CMHSP) in Michigan, organized into 10 regions known as a "Prepaid Inpatient Health Plan" (PIHP), grappled with the task of developing a modified plan of operations, while complying with mitigation and social distancing guidelines. With the premise that psychiatric care is essential healthcare, a panel of physician and non-physician leaders representing Region 5, met and developed recommendations, and feedback iteratively, using an adaptive modified Delphi methodology. This facilitated the development of a service and patient prioritization document to triage and to deliver behavioral health services in 21 counties which comprised Region 5 PIHP. Our procedures were organized around the principles of mitigation and contingency management, like physical health service delivery paradigms. The purpose of this manuscript is to share region 5 PIHP's response; a process which has allowed continuity of care during these unprecedented times.

Contingency plan

Triage

Pandemic

Social distance

Delphi Method

10.1007/s10597-020-00677-6

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Citations (20)

Sleep duration associates with moderate-to-vigorous intensity physical activity and body fat in 1- to 3-year-old children

Infant Behavior and Development (2019)

Isabella Theresa Felzer-Kim Janet Hauck

Intensity

Sleep

10.1016/j.infbeh.2019.101392

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Citations (11)

When Stimulants “Fail” for Children With Attention-Deficit/Hyperactivity Disorder

Consultant (2020)

Zakia Alavi Isabella Theresa Felzer-Kim Heide Hullsiek Rollins

Attention deficit disorder

Attention deficits

10.25270/con.2020.07.00005

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Citations (0)

DrosophilaMuller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

G3 Genes Genomes Genetics (2015)

Wilson Leung C. Shaffer Laura K. Reed Sheryl T. Smith William D. Barshop

Abstract The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.

Euchromatin

Gene density

P element

10.1534/g3.114.015966

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Citations (94)

The Perspectives of Preservice Kinesiology Students Concerning Autism and Physical Activity: Differences by Adapted Physical Activity Exposure

Journal of Physical Activity and Health (2023)

Janet Hauck Isabella Theresa Felzer-Kim

This study investigated the effect of an adapted physical activity (APA) course on knowledge and perceptions of preservice trainees regarding physical activity (PA) and autism spectrum disorder in 3 areas: knowledge/perspectives, importance and ease of improving developmental domains, and importance and ease of improving motor skills.Four hundred upper-level undergraduate students were recruited to participate in this survey-based study (251 APA students and 149 non-APA students participated). Survey data were analyzed using multivariate analyses of variance.Participants estimated that the moderate to vigorous PA recommendations are 39.34 minutes per day, that 46.65% of moderate to vigorous PA occurs during school, and that 61.03% of children have motor difficulties. Participants perceived activities of daily living, sleep habits, and heart health as the easiest domains to improve, and problem behaviors, social skills, and self-esteem as the most difficult domains to improve. Knowledge/perspectives regarding autism spectrum disorder and PA were different by APA exposure (F12,324 = 3.11, P < .001). Differences included self-efficacy in providing PA advice, knowledge of PA guidelines, and willingness to provide motor assessment referrals. Students differed by APA exposure in the importance of developmental domains (F8,381 = 4.37, P < .001) but not ease of improving those domains.Results suggest that APA education and contact with children with disabilities improves self-efficacy, perspectives, and knowledge of PA and motor concerns in children with autism spectrum disorder.

Kinesiology

10.1123/jpah.2022-0027

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Citations (2)

Stu2 acts as a microtubule destabilizer in metaphase budding yeast spindles

Molecular Biology of the Cell (2017)

Lauren Humphrey Isabella Theresa Felzer-Kim Ajit P. Joglekar

The microtubule-associated protein Stu2 (XMAP215) has the remarkable ability to act either as a polymerase or as a destabilizer of the microtubule plus end. In budding yeast, it is required for the dynamicity of spindle microtubules and also for kinetochore force generation. To understand how Stu2 contributes to these distinct activities, we analyzed the contributions of its functional domains to its localization and function. We find that Stu2 colocalizes with kinetochores using its TOG domains, which bind GTP-tubulin, a coiled-coil homodimerization domain, and a domain that interacts with plus-end interacting proteins. Stu2 localization is also promoted by phosphorylation at a putative CDK1 phosphorylation site located within its microtubule-binding basic patch. Surprisingly, however, we find that kinetochore force generation is uncorrelated with the amount of kinetochore-colocalized Stu2. These and other data imply that Stu2 colocalizes with kinetochores by recognizing growing microtubule plus ends within yeast kinetochores. We propose that Stu2 destabilizes these plus ends to indirectly contribute to the "catch-bond" activity of the kinetochores.

Budding yeast

Astral microtubules

Spindle pole body

Budding

10.1091/mbc.e17-08-0494

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Citations (18)

Working With Children With Autism in General Physical Education: Useful Applied Behavior Analysis Concepts

Journal of Physical Education Recreation & Dance (2021)

Isabella Theresa Felzer-Kim Hannah Cruickshank Campbell Neha Vallabheneni Andrea M. Peterson Janet Hauck

This article addresses six concerns raised by physical education teachers regarding working with children with Autism Spectrum Disorder: 1. Creating Engaging Programs; 2. Distracting/Negative Peer Relationships; 3. Emotional Regulation Difficulty; 4. Communicating the Task; 5. Narrow Focus and Adherence to Routines and Structure; and 6.Need for Support. The ABA concepts of functional behavior assessment, antecedent intervention, reinforcement, peer interventions, task analysis, and prompting are explained in the general physical education context with concrete ideas for practicing teachers.

Applied behavior analysis

Physical Education

10.1080/07303084.2021.1977741

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Citations (0)