Manzer J. Durrani

Infusion (South Africa)

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Mansoor A. Khan

Quality Research

Michelle Y. Chow

University of Missouri–Kansas City

Andrew Qu

Tencent (China)

Indra K. Reddy

Texas A&M Health Science Center

Ramesh S. Kashi

Bristol-Myers Squibb (United States)

Sanjeev Kumar Gupta

GLA University

R. F. Whitaker

Steven H. Neau

Philadelphia University

Shailesh K. Singh

Indian Institute of Petroleum

Avraham Yacobi

Taro Pharmaceuticals (United States)

Cooperative Institutions

University of Utah

University of Louisiana at Monroe

University of Michigan–Ann Arbor

University of California, San Francisco

Baxter (United States)

University of Kansas

University at Buffalo, State University of New York

University of Missouri–Kansas City

Merck & Co., Inc., Rahway, NJ, USA (United States)

Pfizer (United States)

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Transparent Interconnection of Lots of Links (TRILL): Centralized Replication for Active-Active Broadcast, Unknown Unicast, and Multicast (BUM) Traffic

Wanming Hao Ye Li Manzer J. Durrani Sanjeev Kumar Gupta Andrew Qu

In Transparent Interconnection of Lots of Links (TRILL) active-active access, a Reverse Path Forwarding (RPF) check failure issue may occur when using the pseudo-nickname mechanism specified in RFC 7781. This document describes a solution to resolve this RPF check failure issue through centralized replication. All ingress Routing Bridges (RBridges) send Broadcast, Unknown Unicast, and Multicast (BUM) traffic to a centralized node with unicast TRILL encapsulation. When the centralized node receives the BUM traffic, it decapsulates the packets and forwards them to their destination RBridges using a distribution tree established per the TRILL base protocol (RFC 6325). To avoid RPF check failure on an RBridge sitting between the ingress RBridge and the centralized replication node, some change in the RPF calculation algorithm is required. RPF checks on each RBridge MUST be calculated as if the centralized node was the ingress RBridge, instead of being calculated using the actual ingress RBridge. This document updates RFC 6325.

Unicast

Replication

10.17487/rfc8361

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Citations (0)

Bioavailability of N-acetylprocainamide from mixed diet in rats.

PubMed (1981)

Kamath Bl Avraham Yacobi Gupta Sd Herman F. Stampfli Manzer J. Durrani

The purpose of this study was to determine the bioavailability of N-Acetylprocainamide (NAPA) from mixed diet in rats. Six groups of 8 male Charles River CD rats received NAPA-HCl as follows: Group I, an intravenous dose (mean 21 mg) of 14C-labelled drug. Group II, in a solution given by oral gavage with and without feed (50 mg) in a two-way crossover fashion. Groups III-VI, incorporated in diet (42-68 mg). Urine and feces were collected for 48 hours and assayed for NAPA and procainamide by a specific HPLC method. On the average, 73% of the drug was eliminated unchanged in urine. Only a small percentage (3-4%) of the intact drug was recovered in feces after intravenous or oral administration. There were no detectable levels of procainamide in urine and feces. The absolute bioavailability of NAPA from oral solution with and without feed was 87 and 90%, respectively, and from the mixed diet was 84-92%. There was no statistically significant difference between the bioavailability of NAPA from solution in fasted and fed rats or from NAPA-mixed diet, indicating that the absorption of the drug in rats was not affected by food. The relative bioavailability of the drug from mixed diet ranged from 94-103%.

NAPA

Crossover study

Procainamide

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Transparent Interconnection of Lots of Links (TRILL) Active-Active Edge Using Multiple MAC Attachments

Meixiang Zhang Radia Perlman Hongjun Zhai Manzer J. Durrani Sanjeev Kumar Gupta

TRILL (Transparent Interconnection of Lots of Links) active-active service provides end stations with flow-level load balance and resilience against link failures at the edge of TRILL campuses, as described in RFC 7379.This document specifies a method by which member RBridges (also referred to as Routing Bridges or TRILL switches) in an active-active edge RBridge group use their own nicknames as ingress RBridge nicknames to encapsulate frames from attached end systems.Thus, remote edge RBridges (who are not in the group) will see one host Media Access Control (MAC) address being associated with the multiple RBridges in the group.Such remote edge RBridges are required to maintain all those associations (i.e., MAC attachments) and to not flip-flop among them (as would occur prior to the implementation of this specification).The design goals of this specification are discussed herein.

10.17487/rfc7782

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Formulation and process considerations for beads containing Carbopol® 974P, NF resin made by extrusion-spheronization

International Journal of Pharmaceutics (2000)

Steven H. Neau Michelle Y. Chow Gregory A. Hileman Manzer J. Durrani Ferdous Gheyas

Chlorpheniramine Maleate

Bead

10.1016/s0378-5173(00)00372-0

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A Novel Wet Granulation Method for Carbopol® Resin. I. Extragranular Addition

Drug Development and Industrial Pharmacy (1997)

Manzer J. Durrani R. F. Whitaker P. A. Manji

Granulation

10.3109/03639049709146157

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Effect of metal cations on the conformation and inactivation of recombinant human factor VIII

Journal of Pharmaceutical Sciences (2004)

Tiffany Derrick Ramesh S. Kashi Manzer J. Durrani Ashish Jhingan C. Russell Middaugh

Conformational isomerism

10.1002/jps.20167

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Citations (37)

Pharmacokinetics of Procainamide and N-Acetylprocainamide in Rats

Journal of Pharmaceutical Sciences (1981)

Burde L. Kamathx Chii‐Ming Lai Surinder D. Gupta Manzer J. Durrani Avraham Yacobi

Procainamide

10.1002/jps.2600700319

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Citations (13)

Studies on Drug Release Kinetics from Carbomer Matrices

Drug Development and Industrial Pharmacy (1994)

Manzer J. Durrani A.H. Andrews R. F. Whitaker Sven Benner

The objective of this study is to gain a mechanistic understanding of drug release kinetics from directly compressed tablets containing Carbopol 934P and 974P resins. Carbopol resins belong to a family of carbomers which are synthetic, high molecular weight, non-linear polymers of acrylic acid, crosslinked with polyalkenyl polyether. They are currently being used as polymeric matrices for controlling drug release in pharmaceutical tablets. This investigation focuses on the influence of the type of drug and the pH of the dissolution media, along with other factors on the drug release kinetics from carbomer matrices. Directly compressed tablets were prepared using a Stokes single station laboratory press and blends of polymers and lactose with drugs like theophylline, norephedrine HCI, and chlorpheniramine maleate. In vitro. drug release studies from the tablets were performed according to USP method II. Drug release rates were obtained by plotting the fraction released versus time and data fitted to the equation:

Acrylic acid

Chlorpheniramine Maleate

Pharmaceutics

10.3109/03639049409042648

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Citations (30)

Transparent Interconnection of Lots of Links (TRILL) Distributed Layer 3 Gateway

Hao Wu Y. Li Andrew Qu Manzer J. Durrani P. Sivamurugan

The base TRILL (Transparent Interconnection of Lots of Links) protocol provides optimal pair-wise data frame forwarding for Layer 2 intra-subnet traffic but not for Layer 3 inter-subnet traffic.A centralized gateway solution is typically used for Layer 3 intersubnet traffic forwarding but has the following issues:1. Sub-optimum forwarding paths for inter-subnet traffic.2. A centralized gateway that may need to support a very large number of gateway interfaces in a Data Center, one per tenant per Data Label used by that tenant, to provide interconnect functionality for all the Layer 2 Virtual Networks in a TRILL campus. 3.A traffic bottleneck at the gateway.This document specifies an optional TRILL distributed gateway solution that resolves these centralized gateway issues.

Gateway (web page)

10.17487/rfc7956

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Prodrug-Based Transdermal Drug Delivery: a Physical Model Approach to Simultaneous Transport and Metabolism of Vidarabine-2',3'-Diacetate in Hairless Mouse Skin.

Deep Blue (University of Michigan) (1986)

Manzer J. Durrani

Hairless

Vidarabine

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