Marco Chahuàn

Sociedad de Biología de Chile

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Eduardo Giugno

University of Belgrano

Hugo Benítez

Hospital Regional de Antofagasta

Marta Adonis

University of Chile

Cláudia Soares

GlaxoSmithKline (Brazil)

K.P. Viana

GlaxoSmithKline (Brazil)

Pablo Avaria

University of Chile

Fabio Bolívar

Asociación Colombiana de Neumología y Cirugía de Tórax

Edith Vallejo-Perez

Universidad de Morelia

Hugo Neffen

Centro Científico Tecnológico - Santa Fe

M.Fernandez Campos

Hospital Barros Luco-Trudeau

Cooperative Institutions

University of Chile

Sociedad de Biología de Chile

GlaxoSmithKline (Brazil)

Pontificia Universidad Católica de Chile

Hospital San Borja Arriarán

Hospital Regional de Antofagasta

Universidad de Santiago de Chile

Instituto Nacional del Tórax

Fundación Chile

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

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Key factors associated with uncontrolled asthma – the Asthma Control in Latin America Study

Journal of Asthma (2019)

Hugo Neffen Marco Chahuàn Dante D Hernández Edith Vallejo-Perez Fabio Bolívar

Objective: This study aimed to estimate asthma control at specialist treatment centers in four Latin American countries and assess factors influencing poor asthma control.Methods: Patients aged ≥12 years with an asthma diagnosis and asthma medication prescription, followed at outpatient specialist centers in Argentina, Chile, Colombia, and Mexico, were included. The study received all applicable ethical approvals. The Asthma Control Test (ACT) was used to classify patients as having controlled (ACT 20-25) or uncontrolled (ACT ≤19) asthma. Frequency and statistical tests were used to assess the association between hospital admissions/exacerbations/emergency department (ED) visits and uncontrolled asthma; multivariate logistic regression was used to assess the association of uncontrolled asthma with clinical/demographic variables.Results: A total of 594 patients were included. Overall controlled-asthma prevalence was 43.4% (95% confidence interval [CI]: 39.0, 47.4). Patients with uncontrolled asthma were more likely to be women (adjusted odds ratio [aOR]: 1.85; p = 0.003), non-white (aOR: 2.14; p < 0.001), obese (aOR: 1.71; p = 0.036), to have a low monthly family income (aOR: 1.75; p = 0.004), to have severe asthma (aOR:1.59; p = 0.26), and, compared with patients with controlled asthma, to have a higher likelihood of asthma exacerbations (34.5% vs. 15.9%; p < 0.001), hospital admissions (6.9% vs. 3.1%; p = 0.042), and ED visits (34.5% vs. 15.9%; p < 0.001) due to asthma.Conclusions: Even in specialist ambulatory services, fewer than half of patients were classified as having controlled asthma. The proportion of uncontrolled patients varied according to clinical and demographic variables.

10.1080/02770903.2018.1553050

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Citations (31)

Uncontrolled Asthma in Specialized Centers in Latin America: Findings from the Asthma Control in Latin America (ASLA) Study

Journal of Allergy and Clinical Immunology (2017)

Hugo Neffen Edith Vallejo-Perez Marco Chahuàn Eduardo Giugno Dante Daniel Hernández-Colín

Univariate analysis

10.1016/j.jaci.2016.12.668

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Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population

Biological Research (2014)

Marta Adonis José Francisco Díaz Fernández Veronica R Miranda Marco Chahuàn Alcídes Zambrano

The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been reported to have the highest LC mortality rate in Chile and its inhabitants were exposed to arsenic in their drinking water in concentrations as high as 870 μg/L. Non-invasive techniques such as biomarkers (Automatic Quantitative Cytometry: AQC and DR70) and Auto Fluorescence Bronchoscopy (AFB) might be potentially useful as a supplementary diagnostic approach and early detection. Early detection is one of the most important factors to intervene and prevent cancer progression in LC. This is a work of an ongoing prospective bimodality cancer surveillance study in high risk LC volunteers. Enrolment was done in subjects from Antofagasta and Metropolitan regions. In addition, we enrolled subjects who were suspected of having lung cancer. AQC, DR70 and AFB were used as tools in the detection of pre-neoplastic (PNL) and neoplastic lesions (NL). Half of the samples, classified as suspicious by AFB, were confirmed as metaplasia or dysplasia by histopathology. For LC, DR70 showed a higher sensitivity (95.8%) and specificity (91.9%) than AQC. However, for PNL AQC showed a higher sensitivity (91.9%) than DR70 (27.3%), although both with low PPV values. As a pre screener, both biomarkers might be employed as complementary tools to detect LC, especially as serially combined tests, with a sensitivity of 60% and a PPV of 65.2%. Additionally, the use of parallel combined tests might support the detection of PNL (sensitivity 91.2%; PPV 49.1%). This work adds information on cellular and molecular biomarkers to complement imaging techniques for early detection of LC in Latin America that might contribute to formulate policies concerning screening of LC. Supported by INNOVA-CORFO, Chile.

Histopathology

10.1186/0717-6287-47-62

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Recomendaciones Rama de Dermatología Pediátrica, Sociedad Chilena de Pediatría. Pandemia COVID-19

Revista chilena de pediatría (2020)

Ma. Angélica Macias E.Estela Zapata G.Ma. Carolina González A.Héctor Fuenzalida Juan Honeyman

La actual pandemia por Covid-19 (SARS-CoV-2) corresponde a una zoonosis viral altamente contagiosa que ha requerido extremar las medidas de protección personal con el fin de disminuir la transmisión del virus, tanto en ambientes hospitalarios como fuera de ellos, siendo necesaria la adopción de estrictos métodos de aislamiento tanto de contacto como aerosoles. Esto ha requerido la adopción de múltiples equipos de protección personal, dentro de los que se encuentran la protección ocular, mascarillas, escudo de protección facial, gorros, guantes, etcétera. Lo anterior ha generado un aumento en el daño de la barrera cutánea y, por lo tanto, la aparición de diversas dermatosis dentro de las que se encuentran dermatitis de contacto irritativa o alérgica, reacciones acneiformes, agravamiento de dermatosis previas, entre otras, cobrando así vital importancia el cuidado y restablecimiento de la barrera cutánea con medidas esenciales como aplicación de productos humectantes o emolientes y el correcto uso de los equipos en mención. No obstante, no solo se generan dermatosis derivadas del uso de equipos de protección personal, sino que también, dentro del amplio espectro de manifestaciones dermatológicas que puede generar la enfermedad por Covid-19 propiamente tal, incluyendo compromiso cutáneo, piloso (efluvio telógeno) o ungueal (onicomadesis). Por otro lado pero no motivo de este artículo, el compromiso cutáneo puede corresponder a la primera expresión clínica de la enfermedad o ser un predictor de su evolución. Dentro de lo anterior encontramos la urticaria aguda, exantema maculo-papular, exantema varicela-like, erupción petequial, perniosis-like y lívedo reticularis como las principales formas de afección cutánea hasta el momento.

10.32641/rchped.v91i7.2485

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[Hepatopulmonary syndrome in decompensated cirrhotic patients].

PubMed (1995)

Juan Pablo Roblero Luca Corradi Marco Chahuàn H Iturriaga

Hypoxemia is common in cirrhotic patients and, when obvious pulmonary or cardiac causes are discarded, it is attributed to the so-called hepatopulmonary syndrome. The aim of this work was to assess the frequency of hypoxemia and orthodeoxia and its relationship with the degree of liver failure, in cirrhotic alcoholic patients. We studied 30 alcoholic cirrhotics. In all, arterial blood gases were measured in supine and standing positions, in 26 a chest X ray examination was done and in 20 a spirometry. Twelve patients had a subnormal PaO2 and this parameter fell more than 105 when assuming the standing position in one of these. The same reduction was observed in two subjects with normal supine PaO2. In the chest X ray examinations, pleural effusions were observed in five hypoxemic subjects and four with normal PaO2. Likewise minimal athelectasis was found in six and seven subjects and intestinal infiltrates in one of the two subjects. A significant association between hypoxemia and Pugh score was observed. Similarly, subjects with hypoxemia is frequent in alcoholic cirrhotic patients and, since it is not associated to obvious pulmonary causes, it may be attributed to the hepatopulmonary syndrome.

Hepatopulmonary syndrome

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Arterial blood

Arterial oxygen tension

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Relationship Between Toxicogenomic and Environment and Lung Cancer

InTech eBooks (2013)

Marta Adonis Marco Chahuàn Alcídes Zambrano Pablo Avaria James H. Diaz

10.5772/55663

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Citations (1)