Frank Gannon

QIMR Berghofer Medical Research Institute

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George Reid

Translational Genomics Research Institute

Francesco Casciello

QIMR Berghofer Medical Research Institute

Gilles Flouriot

Institut de Recherche en Santé, Environnement et Travail

Jason S. Lee

QIMR Berghofer Medical Research Institute

Gregory M. Kelly

University of Pennsylvania

Stefanie Denger

European Molecular Biology Laboratory

Steven A. Johnsen

Robert Bosch Hospital

Ingolf Bach

University of Massachusetts Chan Medical School

Thomas Rau

Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer

Klaus Pantel

Universität Hamburg

Cooperative Institutions

St. James's Hospital

317

University College Dublin

256

Trinity College Dublin

234

Ollscoil na Gaillimhe – University of Galway

174

Beaumont Hospital

159

Royal College of Surgeons in Ireland

158

St. Vincent's University Hospital

155

Mater Misericordiae University Hospital

128

St. Vincent's Hospital

126

St Vincent's Hospital

121

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The sequential pathology of pancreas disease in Atlantic salmon farms in Ireland

Journal of Fish Diseases (1992)

Thomas M. Murphy H. D. Rodger E. M. Drinan Frank Gannon Peter D. Kruse

Abstract A description is given of cardiac and skeletal myopathy in Atlantic salmon, Sahno salar L., during pancreas disease. Post‐smous in two farms were sampled weekly from April to Oetober. Panereas disease was diagnosed at 9 and 13 weeks after sea transfer on the two farms, respeetively. Myodegenerative lesions were observed in the hearts of fish with hoth normal and diseased panereas. The prevalenee of heart lesions was highest amongst fish affeetcd with panereas disease. Skeletal myopathy of red fibres was observed only in fish in the recovery and chronic phases of disease, whereas white fibre changes were observed in fish with normal pancreas and fish affeetcd with panereas disease.

10.1111/j.1365-2761.1992.tb01239.x

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Citations (58)

The discovery of functional genomics

EMBO Reports (2000)

Frank Gannon

Functional Genomics

10.1093/embo-reports/kvd104

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Citations (3)

Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

Cancer Research (2008)

Nancy Bretschneider Heike Brand Nicola Miller Aoïfe Lowery Michael J. Kerin

Abstract The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function as a breast cancer marker. In MCF7 cells, BASE is repressed by estrogen in an estrogen receptor α (ERα)-dependent manner. Promoter analysis of the BASE gene led to the identification of a 2-kb upstream enhancer that harbors binding sites for ERα and FoxA1. The recruitment of both ERα and FoxA1 to this region was shown by chromatin immunoprecipitation analysis. Furthermore, mutation studies and knockdown experiments show a clear separation between gene expression mediated by FoxA1 and ERα-dependent gene regulation. Additionally, we provide information on BASE expression in human breast tumor samples. [Cancer Res 2008;68(1):106–14]

FOXA1

Estrogen receptor alpha

Chromatin immunoprecipitation

Estrogen receptor beta

10.1158/0008-5472.can-07-5647

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Citations (27)

The identification of cDNA clones that include the 3′ end of mRNA

Gene Analysis Techniques (1989)

Tom Barry Marie Stack Andrew Morgan Frank Gannon

Identification

Southern blot

Northern blot

10.1016/0735-0651(89)90009-5

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Citations (2)

E2‐mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements

Molecular Oncology (2008)

Nancy Bretschneider Sara Kangaspeska Martin Seifert George Reid Frank Gannon

Estrogen receptor alpha

10.1016/j.molonc.2008.05.004

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Citations (44)

A role for HNF-3 in the regulation of the HNF-1 gene of the Atlantic salmon

Molecular Genetics and Genomics (2002)

C. Stenson-Cox Alan McNair Michael Curley Terry Smith Frank Gannon

Hepatocyte nuclear factors

5' flanking region

Transcription

10.1007/s00438-001-0602-0

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Citations (3)

DNA probe for Aeromonas salmonicida

Applied and Environmental Microbiology (1992)

Maura Hiney M. Dawson David M. Heery P.R. Smith Frank Gannon

A DNA fragment that is specific to Aeromonas salmonicida has been isolated from a genomic DNA library by differential hybridization. The specificity of this fragment as a DNA probe for A. salmonicida was shown by hybridization against reference strains and clinical isolates of A. salmonicida, related aeromonads, and species from several other bacterial genera. The sensitivity of detection by a polymerase chain reaction test, based on this fragment, was approximately two A. salmonicida cells.

Aeromonas salmonicida

Hybridization probe

genomic DNA

DNA–DNA hybridization

10.1128/aem.58.3.1039-1042.1992

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Citations (98)

Then and now

EMBO Reports (2004)

Frank Gannon

10.1038/sj.embor.7400214

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Citations (0)

Presence of an Extended Duplication in the Putative Low-Density-Lipoprotein Receptor-Binding Domain of Apolipoprotein B. Cloning and Characterization of the Domain in Salmon

European Journal of Biochemistry (1995)

Patrick J. Babin François Deryckère Frank Gannon

The sequence of the C-terminal 1058 amino acids of atlantic salmon (Salmo salar) apolipoprotein (apo) B was deduced from the nucleotide sequence of cloned cDNA. In comparison with chicken or mammals apoB-100, salmon apoB is C-terminally truncated and extended gaps are found. The two clusters of positively charged residues, previously identified as part of the putative low-density-lipoprotein (LDL) receptor-binding domain of apoB, are brought into close proximity in salmon apoB. This is achieved by the absence between the two clusters of the proline-rich area with the potential to form an amphipathic beta sheet, present in higher vertebrates. In addition, analysis of apoB amino acid sequences currently available in vertebrates revealed the presence of an extended internal duplication in the putative LDL receptor-binding domain. Thus, the two basic clusters would have been duplicated resulting in the presence, except for salmon apoB, of two homologous sites in the C-terminal part of the molecule. The results described here together with earlier biochemical and genetic evidence support the view that Arg3500, a residue mutated in familial defective apoB-100, could be included in a folded critical region of the putative LDL receptor-binding domain of human apoB-100. This region possibly brings the two sub-domains that arise from the duplication close to each other.

C-terminus

10.1111/j.1432-1033.1995.tb20532.x

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Citations (12)

Variations on complexity

EMBO Reports (2008)

Frank Gannon Nonia Pariente

10.1038/embor.2008.85

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Citations (1)