Marzena Gutowicz

University of Zielona Góra

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Anna Barańczyk‐Kuźma

Medical University of Warsaw

Justyna Pyrzanowska

Medical University of Warsaw

Ewa Widy‐Tyszkiewicz

Medical University of Warsaw

Agnieszka Siwińska-Ziółkowska

Medical University of Warsaw

Małgorzata Chołojczyk

Medical University of Warsaw

Maria Pokorska-Lis

Medical University of Warsaw

Beata Kaźmierczak

Pomeranian Medical University

Piotr Janik

Medical University of Warsaw

B Sadurska

Medical University of Warsaw

Agnieszka Zembroń-Ƚacny

University of Zielona Góra

Cooperative Institutions

Medical University of Warsaw

University of Zielona Góra

Academic Center of Medicine

Wojskowy Instytut Medyczny

Laboratoire de Biochimie

The Maria Sklodowska-Curie National Research Institute of Oncology

University of Warsaw

University School of Physical Education in Kraków

San Antonio College

University of Coimbra

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Wpływ wieku i suplementacji kurkuminą na skuteczność mechanizmów detoksykacyjnych w tkankach szczura

Medycyna Weterynaryjna (2011)

Marzena Gutowicz A. Augustyn J. Pyrzanowska E. Widy-Tyszkiewicz A. Baranczyk-Kuzma

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Antioxidant status human brain intoxicated by heroin and psychotropic drugs

Acta Biochimica Polonica (2003)

Marzena Gutowicz Maria Pokorska-Lis S. Szymczakowski Anna Barańczyk‐Kuźma

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Antioxidant and detoxycative mechanisms in central nervous system

Postępy Higieny i Medycyny Doświadczalnej (2020)

Marzena Gutowicz

Since the brain contains a large amount of polyunsaturated fatty acids, consumes up to 20% of oxygen used by the whole body and exhibits low antioxidants activity, it seems to be especially vulnerable to oxidative stress. The most important antioxidant enzymes are superoxide dismutase (SOD), which catalyze the dismutation of superoxide anion to hydrogen peroxide, catalase (CAT), which converts toxic hydrogen peroxide to water and oxygen, and glutathione peroxidase (Se-GSHPx), which reduces hydrogen peroxide and organic peroxides with glutathione as the cofactor. Among other detoxifying enzymes, the most significant is glutathione transferase (GST), which shows detoksyvarious catalytic activities allowing for removal of xenobiotics, reducing organic peroxides and oxidized cell components. One of the most important brain nonenzymatic antioxidants is reduced glutathione (GSH), which (individually or in cooperation with peroxidases) participates in the reduction of free radicals, repair of oxidative damage and the regeneration of other antioxidants, such as ascorbate or tocopherol. Glutathione as a cosubstrate of glutathione transferase scavenges toxic electrophilic compounds. Although the etiology of the major neurodegenerative diseases are unknown, numerous data suggest that reactive oxygen species play an important role. Even a small change in the level of antioxidants can leads to the many disorders in the CNS.

Glutathione reductase

GPX4

10.5604/01.3001.0013.8548

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Antioxidant status in different regions of heroin addicts’ brain

Environmental Toxicology and Pharmacology (2005)

Marzena Gutowicz B Sadurska Małgorzata Chołojczyk Maria Pokorska-Lis Agnieszka Siwińska-Ziółkowska

Malondialdehyde

10.1016/j.etap.2005.07.014

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Intracellular transport proteins: classification, structure and function of kinesins

Postępy Higieny i Medycyny Doświadczalnej (2011)

Agnieszka Chudy Beata Gajewska Marzena Gutowicz Anna Barańczyk‐Kuźma

Correct cell functioning, division and morphogenesis rely on efficient intracellular transport. Apart from dyneins and myosins, kinesins are the main proteins responsible for intracellular movement. Kinesins are a large, diverse group of motor proteins, which based on phylogenetic similarity were classified into fourteen families. Among these families, due to the location of their motor domains, three groups have been characterized: N-, C- and M-kinesin. As molecular motors, kinesins transport various molecules and vesicles mainly towards the microtubule plus end (from the cell body) participating in anterograde transport, although there are also kinesins involved in retrograde transport (C-kinesins). Kinesins are also involved in spindle formation, chromosome segregation, and spermatogenesis. Because of their great importance for the correct functioning of cells, mutations in kinesin coding genes may lead to such neurodegenerative diseases as dominant hereditary spastic paraplegia or Charcot-Marie-Tooth disease.

Kinesin

Molecular motor

10.5604/17322693.959271

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P1.003 Glutamic acid to gamma-aminobutyric acid level proportion in Tourette syndrome patients is higher than in controls

Parkinsonism & Related Disorders (2009)

Piotr Janik Anna Kalbarczyk Marzena Gutowicz Anna Barańczyk‐Kuźma

Glutamic acid

Aminobutyric acid

Gamma-Aminobutyric Acid

10.1016/s1353-8020(09)70125-7

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The influence of reactive oxygen species on the central nervous system

Postępy Higieny i Medycyny Doświadczalnej (2011)

Marzena Gutowicz

Oxidative stress can be defined as a rise of oxidative potential or decrease of antioxidant status. Oxidative stress is caused by reactive oxygen species (ROS) which are produced by one-electron reduction of oxygen in the electron transport chain, as well as many other reactions. Effects of ROS can result in cellular membrane damage, structural and functional changes in enzymatic and non-enzymatic proteins, and damage to the DNA structure. Excessive generation of free radicals, decrease of enzymatic antioxidant activity, and/or reducing agents are considered as the main causes of oxidative stress. Since the brain contains a large amount of polyunsaturated fatty acids, consumes up to 20% of oxygen used by the whole body, and shows low antioxidant activity, it seems to be especially vulnerable to oxidative stress. Numerous data show the significant role of oxidative stress in pathogenesis of many neurodegenerative diseases.

10.5604/17322693.933486

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Influence of long-term administration of Curcuma longa extract on explorative activity in aged rats

Journal of Pre-Clinical and Clinical Research (2010)

Justyna Pyrzanowska Agnieszka Piechal Kamilla Blecharz‐Klin Marzena Gutowicz Anna Barańczyk‐Kuźma

The effects of long-term administration of a standardised extract of Curcuma longa on the explorative activity in aged 24-month-old male Wistar rats were estimated in a hole-board test. The animals received the extract orally for two months in rodent chow at doses of 10 and 50 mg/kg/day. The correlations between concentration of some neurotransmitters and amino acids in selected brain regions, as well as the level of corticosterone in plasma (described previously), and the parameters of exploration were calculated. The antioxidant processes (GSH, GST, CAT and MDA levels) in heart and skeletal muscles were also investigated. The results suggested that the explorative activity of plant extract-treated rats was enhanced; however, no correlations between brain neurotransmitter concentration or plasma corticosterone level and the parameters of explorative activity were observed. In biochemical investigation, chronic C. longa extract administration influenced antioxidant processes (CAT, GST and MDA levels) in skeletal muscles of aged rats, but not in the heart muscle.

Corticosterone

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Wplyw narkotykow i etanolu na sprzeganie z glutationem w korze mozgowej czlowieka

Marzena Gutowicz Agnieszka Siwińska-Ziółkowska Anna Barańczyk‐Kuźma

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The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

Nutrients (2021)

Edyta Wawrzyniak-Gramacka Natalia Hertmanowska Anna Tylutka Barbara Morawin Eryk Wacka

One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI n = 33) or high-grade inflammation (HGI n = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.

Subclinical infection

10.3390/nu13113696

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