To evaluate the clinical results of locking proximal femur plate(LPFP), proximal femoral nail antirotation(PFNA) and bipolar hemiarthroplasty(BPH) in the treatment of femoral intertrochanteric fractures in elderly patients.Retrospective analysis of the 86 elderly patients with femoral intertrochanteric fractures during June 2011 and August 2016 were enrolled in this study. The patients were divided into 3 groups: 26 cases in LPFP group included 10 males and 16 females with an average age of (72.54±4.78) years old, 5 cases of type II of Evans, 12 cases of type III and 9 cases of type IV; 39 cases in PFNA group included 17 males and 22 females with an average age of 74.41±5.65, 11 cases of type II, 18 cases of type III and 10 cases of type IV; 21 cases in BPH group included 9 males and 12 females with an average age of 76.23±6.97, 1 case of type II, 10 cases of type III and 10 cases of type IV. The data of three groups were collected for statistical analysis on the following aspects: operation time, intraoperative blood loss, the length of hospital stay, postoperative complications and Harris score of the hip joint function.The wound healed well and no complication occurred. Eighty-four cases were follow-up, while 2 cases were lost, the follow-up rate was 97.6%. The patients were followed up for 22 to 41 months with an average of 26.3 months. For comparison of operation time and time of the hospital stay, BPH group was shorter than the LPFP and PFNA group(F=19.782, 21.981, P<0.05). For comparison of the intraoperative blood loss, the BPH group was less blood loss than the LPFP and PFNA group(F=12.976, P<0.05), while there was no significant means between the LPFP and PFNA group(t=10.879, P>0.05). For comparison of the postoperative complications, LPFP group was higher than BHP and PFNA group(F=30.976, P<0.05), while there was no significant means between LPFP and PFNA group(t=9.902, P>0.05). For comparison of the Harris score of the hip joint at 1 year after operation, BPH and PFNA group were both higher than LPFP group(F=19.692, P<0.05), while there was no significant means between BPH and PFNA group (t=4.971, P>0.05).For elder patient with femoral intertrochanteric fracture, BPH could be the best optional for the shorter operation time and less complications. And the PFNA also could be optional choice for the patients while the LPFP was forbidden for the elder patients.
Objective
To study the correlation of interleukin (IL)-1B three gene loci linkage disequilibrium and the susceptibility of osteoarthritis.
Methods
A case-control study that selecting 300 patients with osteoarthritis and 300 healthy control subjects in Qingdao region. The single nucleotide polymerphisms (SNPs) at positions -511C/T (rs16944), + 3954C/T (rs114363) and -31C/T (rs1143627) in the IL-1B gene promoter were analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and sequencing digestion results. Linkage disequilibrium of IL-1B three gene loci in osteoarthritis group and healthy group were analyzed using a linkage disequilibrium analysis software.
Results
Heterozygous -511CT, + 3954CT genotype were associated with the high risk incidence of osteoarthritis. There was linkage disequilibrium of IL-1B gene in patients with OA and healthy group between three loci. Linkage disequilibrium between rs1143627 and other two loci in healthy group was significantly different than that in OA group (P=0.016).
Conclusion
linkage disequilibrium of IL-1B gene rs1143627 locus is a risk factor in osteoarthritis.
Key words:
Interleukin-1B; Linkage disequilibrium; Osteoarthritis
Objective
To investigate the relationship between blood vessel invasion (BVI) and clinicopathologic features and prognosis in patients with gastric cancer, and analyze related factors affecting the prognosis of patients.
Methods
The clinicopathological data of 206 patients with gastric cancer who were admitted to the Nanjing Hospital Affiliated to Nanjing Medical University from January 2007 to December 2010 were retrospectively analyzed. The BVI of surgical tumor specimens in all patients was detected by immunohistochemical staininng. All the patients were followed up via outpatient examination and telephone interview up to March 2014. The count data were analyzed using the chi-square test. The survival curve was drawn by Kaplan-Meier method. The survival analysis and univariate analysis were done using the Log-rank test, and multivariate analysis was done using the COX regression model.
Results
The BVI rate of 206 patients was 27.67% (57/ 206). The BVI rate of tumor tissues, tumor differentiation, perineural invasion, T stage, N stage and TNM stage in all patients with gastric cancer were compared, showing significant differences (χ2 =14.396, 9.569, 15.579, 43.453, 30.732, P <0.05). After operation, 188 patients were followed up for 6.0-60.0 months (median, 34.0 months) , with the follow-up rate of 91.26% (188/ 206). Among 188 patients with follow-up, the median survival time and 5-year cumulative survival rate in patients with BVI and with negative BVI were 32.4 months and 19.6% , 40.7 months and 42.0% , respectively, with a significant difference in the survival of patients (χ2 =9.364, P <0.05). The results of univariate analysis showed that the diameter of tumor, tumor differentiation, perineural invasion, BVI, T stage, N stage and TNM stage were factors affecting the prognosis of patients with gastric cancer (χ2=9.241, 17.486, 11.243, 9.364, 27.666, 216.745, 49.887, P <0.05). The results of multivariate analysis showed that the diameter of tumor more than 5 cm, BVI, stage T4 , stage N3 and stage Ⅲ were independent risk factors affecting the prognosis of patients with gastric cancer (HR =0.502, 0.456, 0.052, 0.001, 0.735; 95% confidence interval: 0.334-0.754, 0.289-0.720, 0.004-0.664, 0.000-0.006, 0.159-3.398, P <0.05).
Conclusions
BVI in patients with gastric cancer is associated with the progression of tumors. The diameter of tumor more than 5cm, BVI, stage T4 , stage N3 and stage Ⅲ are independent risk factors affecting the prognosis of patients with gastric cancer, and BVI may be a predictor of poor prognosis of patients with gastric cancer.
Key words:
Gastric neoplasms; Blood vessel invasion; Prognosis
Postoperative fever (POF) is a common problem after total joint arthroplasty (TJA). The goal of this research is to analyze the characteristics and risk factors of fever following TJA.We retrospectively investigated 2482 patients who had primary total knee arthroplasty (TKA) or total hip arthroplasty (THA) surgery at our institution between January 2020 and December 2020. Those patients were divided into TKA group and THA group. The patients' axillary temperatures were measured. POF was defined as a body temperature greater than 38 °C. Then patients in the TKA and THA groups were respectively divided into afebrile group and febrile group based on their body temperatures. Temperature changing characteristics of the patients in the febrile group were analyzed and recorded. According to the number of patients in the febrile group, we randomly selected a corresponding number of patients from the afebrile group at a ratio of 1:2 to establish a control group. Gender, hypertension, diabetes, anesthesia, surgical time, and some laboratory data were analyzed between the febrile group and the afebrile group.Three percent of TKA patients (N = 45) had febrile, and in the febrile group of TKA group, 38% (N = 17) had fever and maximum body temperature on postoperative day 2(POD2). Six percent of THA patients (N = 46) had fever, and in the febrile group of THA group, 65% (N = 30) of the patients had fever and maximum body temperature on POD1. In TKA group, compared with afebrile group, febrile group has higher C-reactive protein (mg/L) (CRP) after surgery. In THA group, compared with the afebrile group, the patients in the febrile group had larger fall in hemoglobin (g/L), and higher C-reactive protein (mg/L) (CRP) after surgery, so there were statistically significant differences between the two groups (P < 0.05).The POF rate of TKA is 3%, and the first fever and maximum body temperature most commonly appear on the POD2. THA has a 6% POF rate, and the first fever and the maximum body temperature most commonly appear on the POD1. In both groups, high C-reactive protein is a risk factor for postoperative fever. In addition, the fall in hemoglobin is also related to postoperative fever in the THA group.
Abstract Background: Long non-coding RNAs (lncRNAs) have diverse roles in modulating gene expression on both transcriptional and translational aspects, whereas its role in the metastasis of osteosarcoma (OS) is unclear. Method: Expression and clinical data were downloaded from TARGET datasets. The OS metastasis model was established by seven lncRNAs screened by univariate cox regression, lasso regression and multivariate cox regression analysis. The area under receiver operating characteristic curve (AUC) values were used to evaluate the models. Results: The predictive ability of this model is extraordinary (1 year: AUC = 0.92, 95% Cl = 0.83–1.01; 3 years: AUC = 0.87, 95% Cl = 0.79–0.96; 5 years: AUC = 0.86, 95% Cl = 0.76–0.96). Patients in high group had poor survival compared to low group (p < 0.0001). “NOTCH_SIGNALING”, and “WNT_BETA_CATENIN_SIGNALING” were enriched via the GSEA analysis and dendritic cells resting were associated with the AL512422.1, AL357507.1 and AC006033.2 (p < 0.05). Conclusion: We constructed a novel model with high reliability and accuracy to predict the metastasis of OS patients based on seven prognosis-related lncRNAs.
Long non-coding RNAs (lncRNAs) have diverse roles in modulating gene expression on both transcriptional and translational levels, but their involvement in osteosarcoma (OS) metastasis remains unknown.Transcriptional and clinical data were downloaded from TARGET datasets. A total of seven lncRNAs screened by univariate cox regression, lasso regression, and multivariate cox regression analysis were used to establish the OS metastasis model. The area under the receiver operating characteristic curve (AUC) was used to evaluate the model.The established model showed exceptional predictive performance (1 year: AUC = 0.92, 95% Cl = 0.83-0.99; 3 years: AUC = 0.87, 95% Cl = 0.79-0.96; 5 years: AUC = 0.86, 95% Cl = 0.76-0.96). Patients in the high group had a poor survival outcome than those in the low group (p < 0.0001). GSEA analysis revealed that "NOTCH_SIGNALING" and "WNT_BETA_CATENIN_SIGNALING" were significantly enriched and that resting dendritic cells were associated with AL512422.1, AL357507.1, and AC006033.2 (p < 0.05).Based on seven prognosis-related lncRNAs, we constructed a novel model with high reliability and accuracy for predicting metastasis in OS patients.
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