SPECIFIC AIMSWe have devised an in vivo experimental model to investigate the role of the human papilloma virus (HPV) type 16 E6 and E7 oncoproteins in the development of radiation resistance in advanced cervical carcinoma. HPV negative human C33A cervical carcinoma cells were transfected with E6 and E7 cDNAs and the transfectants subcutaneously (s.c.) transplanted into scid mice. Tumor growth and radiation resistance under normal and hypoxic conditions were assessed in male and female recipients. Patterns of gene expression were investigated in radiation-resistant vs. radiation-sensitive tumors.PRINCIPAL FINDINGS1. Constitutive expression of the E6 protein promotes rapid tumor developmentE6-expressing tumors reproducibly developed more quickly than E7 tumors, which in turn developed more quickly than vector-only control tumors (Fig. 1a⤻ ), although no difference in growth rate was observed in vitro between E6, E7, or control cell lines. Once established, however, tumor growth rates were similar. There wa...

Radiation Resistance

10.1096/fj.00-0728fje

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Citations (62)

Angiogenic markers predict kidney injury and obstetric complications in women with preeclampsia and pregnancy‐related acute kidney injury

Therapeutic Apheresis and Dialysis (2021)

Rasha Samir Shemies Tamer Zaki Gaber Azza Baiomy Doaa A. Aladle Alaa Mosbah

Pregnancy-related acute kidney injury (PRAKI) particularly on top of preeclampsia (PE) represents a major cause of maternal and fetal morbidity and mortality. Reliable diagnostic tools are needed to further evaluate the diagnosis and prognosis of PRAKI. Our objective was to study the diagnostic and prognostic value of angiogenic markers (e.g., stromal cell-derived factor 1 (SDF-1), vascular endothelial growth factor (VEGF), alarmins as uric acid) in women with PE and PRAKI. This prospective study included three groups; PRAKI, PE patients, and healthy controls that were compared regarding serum levels of the studied markers correlated to renal, maternal, and fetal outcomes. SDF-1, VEGF, and uric acid levels were significantly different between the three included groups and predicted PRAKI diagnosis. Patients with hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome exhibited the highest titers of SDF-1 and VEGF. A positive correlation was found between SDF-1 and renal recovery. Conclusively, serum assays of SDF-1, VEGF, and uric acid may add a diagnostic value in PRAKI and PE.

HELLP syndrome

10.1111/1744-9987.13633

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Multilocular intrauterine cystic mass, atypical presentation of endometrial stromal sarcoma: a case report

Archives of Gynecology and Obstetrics (2007)

Reda Ali El‐Said Abdel‐Hady Mostafa El-Zayat

Presentation (obstetrics)

Endometrial stromal sarcoma

Neoplasm

10.1007/s00404-007-0454-x

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Hematological profile and transfusion requirement during hysteroscopic myomectomy: A comparative study between oxytocin and tranexamic acid infusion

Egyptian Journal of Anaesthesia (2012)

Sherif Abdo Mousa Amr M. Yassen Hala Salah Alhadary Ehab Sadek El‐Said Abdel‐Hady

BackgroundOxytocin is uterotonic drug reducing uterine blood loss. Tranexamic acid reduce blood loss in various settings. Data on their efficacy are limited in gynecological hysteroscopy. This study was conducted to compare the effect of oxytocin versus tranexamic acid on hematological profile and transfusion requirement during hysteroscopic myomectomy (HM).MethodsFifty women scheduled for HM were randomly assigned into two groups. Ttranexamic acid (TXA) or oxytocin (OXY). TXA was injected with 15 mg kg−1 of tranexamic acid, followed by infusion of 10 mg kg−1 h−1. In OXY, 10 Unites of oxytocin were added to 500 mL saline (400 mU/min) during surgery. Spinal anesthesia was induced for all patients. Hemodynamics, hematological data, number of transfusions, serum sodium and central venous pressure were measured.ResultsTXA showed significant decrease of heart rate 30 and 45 min and 1 and 2 h when compared with OXY. Post operative Hb and Hct showed significant decrease (p < 0.001) in TXA compared with OXY. CVP in TXA displayed significant increase (p < 0.001) 15 min after spinal blockade and 30 min, 45 min, 1 h and 2 h. Serum sodium showed significant decrease in TXA (p < 0.001) compared with OXY nearly throughout study period.ConclusionUse of oxytocin during HM was accompanied with stable hemodynamics, hematological profile and less transfusion requirement compared with the use of tranexamic acid.

Uterotonic

10.1016/j.egja.2011.12.003

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Why do mothers die in Dakahlia, Egypt?

Journal of Obstetrics and Gynaecology Research (2007)

El‐Said Abdel‐Hady Abdel‐Maguid Mashaly Lotfy S. Sherief Mostafa M. Hassan Alaa Al‐Gohary

Abstract Aim: To investigate the causes of maternal mortality in the Dakahlia Governorate in Egypt. Methods: A confidential enquiry for each case of maternal mortality during the years 2004–2005 was carried out. Results: One hundred and seventy‐nine maternal deaths were reported, giving a maternal mortality rate (MMR) of 71.3/100 000 live births. 140 (78.2%) women died due to direct obstetric causes, 24 (13.4%) due to indirect causes and 15 (8.4%) due to accidental or unexplained causes. 44 (24.6%) women died during or following delivery by cesarean section and 91 (50.8%) during labor or within 24 h following delivery. Complications during cesarean delivery, postpartum hemorrhage and hypertensive disorders were the leading causes of maternal mortality. Death due to substandard care was encountered in 85% of cases. Obstetricians were responsible for 51% of causes of avoidable maternal death. Conclusion: Maternal mortality in Dakahlia, although declining, is still relatively high. To further reduce maternal mortality, deliveries should be conducted at well‐equipped hospitals.

Accidental

Maternal death

Maternal mortality rate

Maternal morbidity

10.1111/j.1447-0756.2007.00525.x

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Prognostic factors of germ cell and sex cord-stromal ovarian tumors in pediatric age: 5 years experience.

PubMed (2013)

Rasha El‐Ashry Reda Hemida Hosam Goda El‐Said Abdel‐Hady

Ovarian tumors in the pediatric age group are not infrequent. Germ-cell tumors are the commonest ovarian neoplasm in the first two decades of life. Sex cord-stromal tumors are the most common ovarian tumors to cause precocious puberty in girls.This retrospective study included all managed cases of malignant germ-cell and sex cord-stromal tumors in the pediatric age (less than 18 years). The medical records of the admitted cases from first of January, 2008 to 31 December, 2012 were reviewed and the following information was collected: patient age, clinical presentation, surgical stage, tumor histology, therapy, clinical course, and outcome. Serum alpha-fetoprotien on admission was studied.The study included 42 pediatric cases of germ-cell and granulosa cell tumors of the ovary. Mean age of the cases was 11.26 years (range: 7-15 years). Abdominal pain was the commonest presentation. Twenty-two cases (52.4%) were diagnosed as stage I disease. Twenty-eight cases (66.7%) were exposed to fertility sparing surgery. Age of the patient and site of tumor were significantly correlated to the survival (p value: 0.04 & 0.09 respectively). The correlations of stage of the disease, use of pre-operative chemotherapy, and type of surgical interference were highly significant (P value: 0.007, 0.001, and 0.001 respectively). Tumor size and histologic types were not significantly correlated to survival (P value: 0.19 & 0.67 respectively).The cumulative survival rate was 76.2%. The correlations of stage of the disease, use of pre-operative chemotherapy, and type of surgical interference were highly significant. Tumor size and histologic types were not significantly correlated to survival. Initial level of alpha-fetoprotein was not significantly correlated to survival or recurrence.

Endodermal sinus tumor

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Maternal and perinatal outcome of pregnancies complicated by cardiac disease

International Journal of Gynecology & Obstetrics (2005)

El‐Said Abdel‐Hady Maged Elshamy Arwa El-Rifai Hosam Goda Ahmed Abdelsamad

Perinatal mortality

10.1016/j.ijgo.2005.03.008

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Citations (48)

Acute kidney injury during pregnancy and puerperium: an Egyptian hospital-based study