Hyun-Guk An

Dongguk University

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Cheorl‐Ho Kim

Korea Forest Service

Sung‐Kwon Moon

Chung-Ang University

Jeong‐Heon Ko

Korea Research Institute of Bioscience and Biotechnology

Young‐Choon Lee

Dong-A University

Hyung‐Min Kim

Kyung Hee University

Byung‐Soo Koo

Dongguk University

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Korea Research Institute of Bioscience and Biotechnology

Dongguk University

Seoul National University

Sungkyunkwan University

Ministry of Science ICT and Future Planning

Korea Institute of Oriental Medicine

Korea Forest Service

Samsung (South Korea)

Agency for Defense Development

Samsung (India)

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Bombycis corpusExtract (BCE) Protects Hippocampal Neurons Against Excitatory Amino Acid-Induced Neurotoxicity

Immunopharmacology and Immunotoxicology (2003)

Byung‐Soo Koo Hyun-Guk An Sung‐Kwon Moon Young‐Choon Lee Hyung‐Min Kim

Bombycis corpus (BC) or Bombyx Batryticatus, a batryticated silkworm and white-stiff silkworm, is a drug consisting of the dried larva of silkworm, Mobyz mori L., dead and stiffened due to the infection of Beauveria (Bals.) Vuill. In a previous paper (Kim et al., Pharmacol. Res., 43, 12–16, 2001), BC was shown to protect amyloid-β-induced cytotoxicity. In the present study, we have found that BCE can prevent or reduce the neurotoxic actions in the hippocampus of the glutamate agonists N-methyl-D-aspartic acid (NMDA) in vitro or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainic acid in vitro. Pre-treatment with BCE (0, 1, 2, 5, and 10 μg/ml for 6–8 h) protected primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM/ml). BCE added either with NMDA (1 mM) or 1 h later had lesser, but still significant, protective actions. BCE also reduced NMDA-induced toxicity (1 mM). BCE (10 μg/ml) protected cultured neurons against the neurotoxic actions of either AMPA (25 μM) or kainic acid (1 mM) as well. Because the release of glutamate has been implicated in the neural damage after cerebral ischemia and other neural insults, these results suggest that BCE may contribute significantly to protect human brain to such damage.

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10.1081/iph-120020469

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