Basharat Ali

Khwaja Fareed University of Engineering and Information Technology

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Nusrat Shafiq

Government College Women University Faisalabad

A. Sultan Nasar

University of Madras

Shagufta Parveen

Government College Women University Faisalabad

Sathiyaraj Subramaniyan

KTH Royal Institute of Technology

Sara Musaddiq

The Women University Multan

Uzma Arshad

Government College Women University Faisalabad

Rajamani Raja

Presidency University

Shahbaz Atta Tung

Pir Mehr Ali Shah Arid Agriculture University

Kiran Mustafa

The Women University Multan

Maryam Rashid

Government College Women University Faisalabad

Cooperative Institutions

University of Agriculture Faisalabad

Government College Women University Faisalabad

University of the Punjab

Government College University, Faisalabad

Islamia University of Bahawalpur

University of Karachi

The Women University Multan

University of Faisalabad

International Center for Chemical and Biological Sciences

Ayub Agriculture Research Institute

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Thiazolidines; The Potential Antimicrobial Agents Against Methicillin-Resistant Strains of Staphylococcus aureus

FRONTIERS IN CHEMICAL SCIENCES (2020)

Mehwish Tanveer Hira Musaddiq Atia Iqbal Sarwat Saleem Sadia Iqbal

2-Substituted 1,3-Thiazolidine-4-Carboxylic Acids (1-11) were synthesized and screened for their anti-methicillin-resistant Staphylococcus aureus (MRSA) potential. The synthesized compounds were evaluated for their antibacterial activities against four MRSA strains MRSA I, VI, VII and VIII with accession numbers KU662352, KR862285, KR862291 and KU662354 respectively by well diffusion method. In addition, antibacterial evaluations were also performed for gram positive strain Bacillus subtilis and gram-negative strains klebsiella pneumoniae and pseudomonas aeruginosa using same method. Most of the synthesized thiazolidine-4-carboxylic acid derivatives exhibited better antibacterial activities against studied bacterial strains. Amongst the synthesized compounds, 8-10 were found to possess significant activity (Zone in mm) against methicillin-resistant Staphylococcus aureus in addition to the other studied bacterial strains.

Thiazolidine

10.52700/fcs.v1i1.3

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Radical dendrimers: Synthesis, anti-tumor activity and enhanced cytoprotective performance of TEMPO free radical functionalized polyurethane dendrimers

European Polymer Journal (2019)

Basharat Ali Bakthavatchalam Velavan Ganapasam Sudhandiran J. Sridevi A. Sultan Nasar

10.1016/j.eurpolymj.2019.109354

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Citations (31)

[Pulmonary tuberculosis secondary to fistulization of Pott's abscess. A case report].

PubMed (1990)

G Aurégan Basharat Ali S Chakib

Spondylodiscitis

Presentation (obstetrics)

Lung abscess

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Citations (2)

Insights into accumulation of active ingredients and rhizosphere microorganisms between Salvia miltiorrhiza and S. castanea

FEMS Microbiology Letters (2023)

Zishu Xu Hui Liu Najeeb Ullah Shahbaz Atta Tung Basharat Ali

Salvia miltiorrhiza is an important traditional herbal medicine, and its extracts could be used for treating cardiovascular disease. Although these medicinal compounds are functionally similar, their wild relative, S. castanea, produces significantly different concentrations of these compounds. The reason for their differences is still unknown. In a series of soil and plant-based analyses, we explored and compared the rhizosphere microbiome of S. miltiorrhiza and S. castanea. To further investigate the geographical distribution of S. castanea, MaxEnt models were used to predict the future suitable habitat areas of S. castanea in China. Results revealed the distributions and structure of the rhizosphere microbial community of S. miltiorrhiza and S. castanea at different times. In addition, differences in altitude and soil moisture resulting from changes in climate and geographical location are also critical environmental factors in the distribution of S. castanea. The findings of this study increase our understanding of plant adaptation to their geographical environment through secondary metabolites. It also highlights the complex interplay between rhizospheric factors and plant metabolism, which provides the theoretical basis for the cultivation of S. miltiorrhiza and the use of S. castanea resources.

Salvia miltiorrhiza

Salvia

10.1093/femsle/fnad102

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Citations (1)

Isolation of bioactive compounds from Rumex hastatus extract and their biological evaluation and docking study as potential anti‐oxidant and anti‐urease agents

Journal of Food Biochemistry (2020)

Nusrat Shafiq Sadia Noreen Naila Rafiq Basharat Ali Shagufta Parveen

Herein, the methanolic extract of Rumex hastatus was prepared and subjected to silica gel column chromatographic separation for purification. The chromatographic analysis yielded four bioactive compounds namely, 1,8-dihydroxy-3-methyl-anthraquinone (C1, chrysophanol), 3-methoxy-7-methyl-1,5-dihydroxy-anthraquinone (C2), 6-methyl-1,3,7-trihydroxy-anthraquinone (C3), and 4-hydroxycinnamic acid (C4). The structures of all the isolated bio-entities were elucidated by spectroscopic analysis (1D, 2D-NMR, and MS). The biological potentialities of bioactive compounds were evaluated by determining their antioxidant and anti-urease activities. The results revealed that compound 1 showed the highest nitrite radical scavenging activity (IC50 = 0.39 mM) followed by C2 and C4 (IC50 = 0.45) mM and C3 (IC50 = 0.47 mM). Similarly, the determined IC50 values for anti-urease activity were C2 (IC50 = 0.39 mM), C1 (IC50 = 0.40), C4 (IC50 = 0.41), and C3 (IC50 = 44). Molecular docking study revealed maximum interactions among the hydroxyl group of all compounds. In conclusion, Rumex hastatus extract could be a promising alternative to chemical additives in pharmaceutical industries due to its noteworthy biological activities. PRACTICAL APPLICATIONS: As we have shown in this study that Rumex hastatus is a prolific source of biologically active compounds with potent antioxidant and anti-urease activities, therefore, R. hastatus extract could be used as a promising alternative to chemical additives in pharmaceutical industries due to its unique compounds and noteworthy biological activities.

Docking (animal)

Isolation

Anti oxidant

10.1111/jfbc.13320

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Citations (12)

Salmonella typhi infection: a rare cause of endocarditis.

PubMed (2011)

Javaid Arif Khan Basharat Ali Tariq Masood Faisal Ahmed Jawaid Akbar Sial

A 21 years old male with a history of mitral valve repair for mitral regurgitation is discussed. He was presented with a history of fever and loose motions for one month and shortness of breath for 03 days. Chest radiograph and ECG was within normal limits. Total leukocyte count was elevated and antibodies to salmonella typhi were positive. Blood culture revealed Salmonella typhi growth. Echocardiography revealed small echogenic masses on mitral valve. He responded to treatment with ceftriaxone given for 4 weeks. This is a rare case where Somonella typhi was isolated from blood of a patient with echocardiographic evidence of documented mitral valve disease and endcarditis.

Chest radiograph

Blood Culture

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Nutritional and Mineral Composition Analysis of Desert Plants: A case study

Emirates Journal of Food and Agriculture (2022)

Javed Iqbal Aqeela Shaheen Muhammad Awais Ghan Qumer Iqbal Muhammad Azam

The wild arid and semi-arid plants of desert are used as food and medicine by the people of Desert. In this case study, selected plants were characterized physico-chemically for their nutritional and mineral importance by different analytical methods. Analysis showed that crude fibers and protein dominated in plant samples among all nutrients with an average concentration of 38% and 21% respectively. The edible parts of plants generally showed higher concentration of Ca and Mg as compared to Na and K. Calligonum polygonoides found comparatively rich in total sugars and ash contents. Similarly, crude fibers (45%), crude lipids (16%) and phosphorous (32 ppm) were observed higher in Leptadenia pyrotechnica. However, Prosopis cineraria contained higher contents of moisture and protein (24%) among other plants. The statistical presentation by discrimination analysis showed that arid plant found rich in most of the nutrients and minerals except phosphorous and proteins as compared to semi-arid plants with relatively higher moisture contents

Desert climate

Prosopis

10.9755/ejfa.2022.v34.i10.2926

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Citations (1)

Crystal structures of 4-chlorophenyl N -(3,5-dinitrophenyl)carbamate and phenyl N -(3,5-dinitrophenyl)carbamate

Rajamani Raja Sathiyaraj Subramaniyan Basharat Ali A. Sultan Nasar

Dinitrophenyl

Carbamate

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Optimization of Conditions for the Synthesis and Oxidation of 5,8-Dimethoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one into Novel 2-Methylisoquinoline-1,5,8(2H)-trione

Orbital - The Electronic Journal of Chemistry (2020)

Basharat Ali Faiz Ahmed Nusrat Shafiq Muhammad Nasrula

Due to stability issue of isoquinolone’s their N -methylation is a challenging task, achieved the synthesis of N -methylated 2-methylisoquinoline-1,5,8(2H)-trione using readily available precursor 2-(2,5-dimethoxyphenyl)ethanamine via multistep strategy, finally oxidation of 5,8-dimethoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one with ceric ammonium nitrate (CAN) lead to target isoquinolone in good yield, further oxidation conditions in final step were optimized using different catalyst ratio, reaction time and temperature conditions. DOI: http://dx.doi.org/10.17807/orbital.v12i1.143

Ceric ammonium nitrate

10.17807/orbital.v12i1.1432

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Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents.

PubMed (2019)

Urooj Nazim Mansoor Ahmed Basharat Ali Khalid Mohammed Khan Mohsin Ali

This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC50 esteems going from 5.1±1.3 - 78.8±4.6μM/mL. Compound 1 (IC50 =5.1±1.9μM) displayed potent result than standard ibuprofen (IC50 = 11.2±1.9 μM). In antiplatelet aggregation assay, five compounds 1, 5, 6, 8 and 11 were observed to be dynamic with IC50 esteems observed in the range of 38.34-255.7±4.1μM, wher eas, aspirin (IC50 = 30.3±2.6 μM) was used as standard. However, compound 11 was found to be good active for both anti-inflammatory and antiplatelet aggregation activities (IC50 = 13.9±4.9μg/mL) (IC50 = 38.60±3.1μM), respectively.

IC50

Ibuprofen

Semicarbazone

Hydrazone

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Citations (5)