Erika Saito

Asahikawa Medical University

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Naoyuki Hasebe

Asahikawa Medical University

Kazumi Akasaka

Asahikawa Medical University

Naoki Nakagawa

Asahikawa Medical University

Nobuyuki Sato

Aomori Prefectural Central Hospital

Tetsuro Kato

Chukyo Hospital

Tatsuru Okamura

Tokyo Metropolitan Komagome Hospital

Motoki Matsuki

Asahikawa Medical University

Steven R. Patierno

Duke University

Masahiko Shibuya

Furuno (Japan)

Ryuji Ieki

University of Tsukuba

Cooperative Institutions

Asahikawa Medical University

The University of Tokyo

Asahikawa Medical College Hospital

Asahikawa University

University of Tokyo Hospital

Kyoto University

Juntendo University

Children's Medical Center

University of Tsukuba

Tokyo Metropolitan Komagome Hospital

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A Long-term Survival Case of Small Cell Lung Cancer in an HIV-infected Patient

Japanese Journal of Clinical Oncology (2005)

Tetsuro Kato Ryuji Ieki Erika Saito Tomohiro Ota Kazumi Yuasa

We report a case of small cell lung cancer in a patient with human immunodeficiency virus (HIV) infection. The patient was a 51-year-old man diagnosed 8 years previously as seropositive for HIV, who was admitted to our hospital for re-evaluation of antiretroviral medications due to multidrug resistance. Chest radiograph revealed an abnormal hilar shadow subsequently confirmed to be small cell lung cancer. He received chemotherapy concurrently with highly active antiretroviral therapy (HAART), and lived for 14 months after the diagnosis. The prognosis of lung cancer in HIV-seropositive patients is very poor, and adverse effects of chemotherapy occur more frequently than in other patients. However, the simultaneous antiretroviral agents and combination chemotherapy was successful. Such treatment may be effective despite an otherwise poor prognosis, including HIV infection.

Chest radiograph

10.1093/jjco/hyi093

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Citations (9)

Aortic regurgitation caused by fibrous strand rupture in a fenestrated aortic valve

Journal of Echocardiography (2012)

Kazumi Akasaka Erika Saito Takaya Higuchi Takako Yanagiya Rie Nakamori

Commissure

Aortic Valve Insufficiency

10.1007/s12574-012-0148-7

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Citations (8)

Adult Accessory Mitral Valve with Septal Hypertrophy

Internal Medicine (2016)

Tatsuya Aonuma Naofumi Takehara Erika Saito Naoyuki Hasebe

10.2169/internalmedicine.55.6865

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Citations (1)

Investigation of atherosclerosis using carotid ultrasonography

Kazumi Akasaka Rie Takai Erika Saito Shuichi Kino Yoshihisa Ito

Carotid ultrasonography is useful for patients in the early stage of atherosclerosis or with manifest vascular disease. We can assess the intima-media thickness (IMT), stenosis, and also elasticity of the carotid artery noninvasively. IMT is well-known as a strong predictor of future vascular events and a surrogate marker of atherosclerosis. We examined 353 consecutive subjects (coronary artery disease: n=92, cerebral vascular disease: n=62, peripheral arterial disease: n=104), regarding whether the accumulation of vascular diseases affects the IMT. The maximum IMT of the common carotid artery expanded with increasing numbers of vascular diseases (no vascular disease, 1.10 +/- 0.51; one vascular disease, 1.38 +/- 0.63; two vascular diseases, 1.69 +/- 0.65; three vascular diseases, 2.01 +/- 0.67 mm; p < 0.01, no vs. one vascular disease, one vs. two vascular diseases). The accumulation of vascular diseases, independent of the types of vascular lesion, accelerated carotid atherosclerosis. The stiffness parameter beta of the carotid artery was related to the brachial-to-ankle pulse wave velocity(baPWV) (n=38, r = 0.81, p < 0.0001). Stiffness parameter beta (10.95 +/- 2.8) and baPWV (1,549 +/- 179 cm/s) in the metabolic syndrome (MetS) group (n=18) was higher than in the preliminary MetS (n=12, 8.82 +/- 1.69, 1417 +/- 148 cm/s) and control (n=8, 7.90 +/- 1.78, 1357 +/- 171 cm/s) groups. The mean IMT of the common carotid artery was not different between the MetS and preliminary MetS groups. Morphological and functional changes in atherosclerosis can be evaluated employing carotid ultrasonography.

Carotid ultrasonography

Intima-media thickness

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Extracellular ATP Stimulates Interleukin-Dependent Cultured Mast Cells and Eosinophils through Calcium Mobilization

International Archives of Allergy and Immunology (1991)

Hirohisa Saito Motohiro Ebisawa Donald C. Reason Kyotaro Ohno Kinji Kurihara

We examined the effect of ATP and related nucleotides on the changes in intracellular calcium ([Ca2+]i) in murine bone marrow-derived mast cells (BMMC) and human cord blood-derived eosinophils (EO) cultured in the presence of interleukins. ATP, ADP and AMP released a substantial amount of histamine and leukotriene C4 from BMMC, and EO showed locomotive activity in response to ATP, ADP and GTP. These reactions were accompanied with an increase in [Ca2+]i in BMMC and in EO. The rise in [Ca2+]i in BMMC induced by ATP or antigen at optimal concentrations was inclined to be persisting. On the other hand, these nucleotides induced a rapid and transient rise in [Ca2+]i in EO. Purified human peripheral EO also exhibited locomotive activity and an increase in [Ca2+]i in response to ATP. These results indicate that extracellular ATP activates interleukin-dependent cultured mast cells and EO through Ca2+ mobilization, and suggest that ATP, which is known to be released from activated platelets or autonomic nerves, may stimulate in vivo counterparts of these cultured inflammatory cells.

Leukotriene C4

Prostaglandin D2

Calcium in biology

10.1159/000235327

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Citations (23)

Severe mitral regurgitation in non-hypertrophic cardiomyopathy caused by systolic anterior motion of the mitral valve

Journal of Medical Ultrasonics (2024)

Tatsuya Aonuma Naoko Kawabata Ayumi Date Erika Saito Kazumi Akasaka

Functional mitral regurgitation

10.1007/s10396-024-01480-6

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Introduction for the Features

Igaku Toshokan (2008)

Asae Ito Erika Saito

り,

10.7142/igakutoshokan.55.130

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PS 05-37 MALNUTRITION, RENAL DYSFUNCTION, AND LEFT VENTRICULAR HYPERTROPHY SYNERGISTICALLY INCREASE THE LONG-TERM INCIDENCE OF CARDIOVASCULAR EVENTS

Journal of Hypertension (2016)

Keisuke Maruyama Naoki Nakagawa Erika Saito Motoki Matsuki Naofumi Takehara

Objective: This study investigated the impact of malnutrition, low estimated glomerular filtration rate (eGFR) and left ventricular hypertrophy (LVH) on cardiovascular events in a long-term observational study. Design and Method: Among 338 patients aged 40–80 years who underwent echocardiographic evaluation between 2003 and 2005, 161 patients followed up for >7 years were recruited. Echocardiographic LVH was defined as left ventricular mass index (LVMI) ≥ 125 g/m2 for men and ≥ 110 g/m2 for women. The geriatric nutritional risk index (GNRI) was used to assess the nutritional status of the patients and was calculated using the following formula: GNRI = (14.89 × serum albumin) + [41.7 × (body weight / body weight at BMI of 22)]. Malnutrition was defined as GNRI ≤ 96. Results: Mean age was 63.5 ± 9.2 years, mean eGFR: 72.9 ± 18.7 ml/min/1.73m2, mean GNRI: 100.4 ± 6.0 and mean LVMI: 114 ± 33 g/m2. The number of patients with eGFR <60 ml/min/1.73m2, GNRI ≤ 96 and LVH was 40 (25%), 32 (20%) and 59 (37%), respectively. During the follow-up period (median: 95 months), cardiovascular events were recorded in 15 patients (9%), including 7 acute coronary syndromes, 4 heart failures, 2 strokes, 1 aortic dissection and 1 aortic rupture. Kaplan-Meier curves showed a significantly higher incidence in patients with eGFR < 60 mL/min/1.73m2 (log rank P = 0.007), GNRI ≤ 96 (P = 0.003), or LVH (P = 0.010) (Figure 1). In Cox proportional hazards analysis, Age, eGFR, LVH, and GNRI were sifnificantly associated with cardiovascular events after adjusting for gender, hemoglobin level, and the prevalence of hypertension and diabetes (Table 1). Conclusions: Malnutrition, low eGFR, and LVH were independent determinants of cardiovascular events; they synergistically increased rates of these events in the long term. It is important to evaluate and manage the progression of LVH and improve nutritional status even in non-dialysis patients.

Body surface area

10.1097/01.hjh.0000500298.27122.c7

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Hyperventilation Syndrome in a Very Old Woman.

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics (1997)

S Teramoto Motoyuki Sugai Erika Saito Takeshi Matsuse Masato Eto

過換気症候群は, 発作的な過換気によって身体, 精神機能異常をきたす機能的疾患であるが, 老年者では比較的稀と報告されている. 我々は, 超高齢者に典型的な過換気症候群を認めたので, 文献的考察を加えて報告した. 症例は, 92歳女性で基礎疾患として高血圧, 緑内障があり, 血圧上昇, 嘔気, 上腹部不快感, 前胸部不快感, 頻呼吸で救急外来を受診した. 収縮期血圧236mmHgであったため, Nifedipine 10mgを舌下して採血などの検査を進めていたところ, 両手のしびれ, 意味不明の大声を発し, 興奮状態となり, 点滴針をはずそうとするため, 鎮静目的に Hydroxyzing 25mgを投与した. この間, 呼吸数が36 (回/分) 前後と多かったため, 過換気症候群を疑い, 動脈血ガス分析を行い, pH 7.590, PO2 95.1mmHg, PCO2 24.1mmHgであったため, 紙袋再呼吸を行った結果, 症状は次第に回復し, 40分後には血液ガスもpH 7.469, PCO2 36.1mmHgへと改善した. その後の検索の結果, 痴呆はなく, 明らかな脳幹の病変もなく, 脳波上も異常はなかった. 過換気テストでは, 今回外来時にみられたような症状は再現されなかったが, その他の検査所見と臨床所見から, 明らかな器質的な病変がないにもかかわらず, 過換気による著しい二酸化炭素分圧の低下とともに多彩な症状を示す典型的な急性の過換気症候群と考えられた.本症例については誘因, 原因について必ずしも明らかにできなかったが, 90歳を超える超高齢者においても典型的な過換気症候群を認めることがあることから, 老年者の意識障害の鑑別疾患として, 稀ではあるが過換気症候群も念頭に置くべきと考えられた.

Tachypnea

Hypocapnia

Hyperventilation syndrome

10.3143/geriatrics.34.226

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Initiatives of a collaborative audit of medical records with the division of hospital safety management and the medical record center

Takashi Hatsuyama Go Katsuya Ayaka Sasaki Runa Yokoyama Erika Saito

Medical record

Center (category theory)

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