Ana Carolina Medeiros

Universidade de São Paulo

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Priscila Medeiros

Universidade de São Paulo

Renato Leonardo de Freitas

Universidade de São Paulo

Norberto Cysne Coimbra

Universidade de São Paulo

José Aparecido Da Silva

Universidade de São Paulo

Sylmara Esther Negrini-Ferrari

Hospital de Sant Pau

Mariana Oliveira-Silva

Universidade de Ribeirão Preto

Glauce Regina Pigatto

Universidade de São Paulo

Josie Resende Torres da Silva

Universidade Federal de Alfenas

Jade Pisssamiglio Cysne Coimbra

Pontifícia Universidade Católica de Campinas

Carlos Roberto Ribeiro de Carvalho

Universidade de São Paulo

Cooperative Institutions

Universidade de São Paulo

Universidade de Ribeirão Preto

Instituto de Neurociências e Comportamento

Hospital Universitário da Universidade de São Paulo

Universidade Estadual Paulista (Unesp)

Universidade Federal de Pernambuco

Universidade Brasil

Universidade Federal de Alfenas

Clinics Hospital of Ribeirão Preto

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

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Physical, Emotional, and Social Pain During COVID-19 Pandemic-Related Social Isolation

Trends in Psychology (2022)

Priscila Medeiros Ana Carolina Medeiros Jade Pisssamiglio Cysne Coimbra Lucas Emmanuel Pedro de Paiva Teixeira Carlos José Salgado-Rohner

Social Isolation

Isolation

Social distance

Disconnection

Distancing

Pandemic

10.1007/s43076-022-00149-8

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Citations (3)

The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

World Journal of Neuroscience (2019)

Priscila Medeiros Sylmara Esther Negrini-Ferrari Ana Carolina Medeiros Laís Ferreira Josie Resende Torres da Silva

Background: The primary motor cortex (M1) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. Furthermore, that neurological procedure may also cause antinociception in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding in patients with neuropathic pain, then, we evaluated if an adapted model of neuropathy induced by chronic constriction injury (CCI) of the ischiadicus nervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain. In addition, we also investigated the effect of the electrical stimulation of the M1 on chronic neuropathic pain condition in laboratory animals. Methods: Male Wistar rats were used. An adapted model of peripheral mononeuropathy induced by CCI was carried out by placing a single loose ligature around the right sciatic nerve. The acetone test was used to evaluate the cold allodynia in CCI or Sham (without ligature) rats. The MCS (M1) was performed at low-frequency (20 μA, 100 Hz) during 15 s by deep brain stimulation (DBS-Thomas Recording device) 21 days after CCI or Sham procedures. The cold allodynia was measured before and immediately after the neurostimulation of M1 in the following time-window: 0, 15 and 30 min after MCS. Results: Cold allodynia threshold increased in animals with chronic neuropathic pain submitted to the acetone test 21 days after the CCI surgery. The M1-stimulation by DBS procedure decreased the cold allodynia immediately and until 30 min after M1-stimulation in rats with chronic neuropathic pain. Conclusion: The current proposal for a CCI model by a single loose ligature of the sciatic nerve can be employed as an experimental model of chronic neuropathic pain in rats submitted to peripheral nervous system injury. The M1-stimulation produced antinociception in rats with chronic neuropathic pain. Thus, we reinforced that the MCS decreases cold allodynia in laboratory animals submitted to persistent sciatic nerve constriction and can be a more reasonable procedure for the treatment of chronic intractable neuropathic pain.

Allodynia

10.4236/wjns.2019.93009

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Citations (8)

Enriched environment prevents hypernociception and depression-like behavior in a psychiatric disorder and neuropathic pain comorbidity experimental condition

Physiology & Behavior (2024)

Priscila Medeiros Ana Carolina Medeiros Renato Leonardo de Freitas Glauce Regina Pigatto Alline C. Campos

Depression

Psychiatric comorbidity

10.1016/j.physbeh.2024.114795

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Citations (0)

Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex-hippocampal connections

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2024)

Ana Carolina Medeiros Priscila Medeiros Glauce Regina Pigatto Sabatino Maione Norberto Cysne Coimbra

Neocortex

Disconnection

10.1016/j.pnpbp.2024.111039

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Citations (5)

Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury

Brazilian Journal of Medical and Biological Research (2020)

Priscila Medeiros Ieda Regina dos Santos Ana Carolina Medeiros José Aparecido Da Silva S. H. Ferreira

The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons. The aim of this work was to clarify the role played by cyclooxygenase (COX) in the lesioned peripheral nerve in the development and maintenance of NP by evaluating at which moment the non-steroidal anti-inflammatory drug indomethacin, a non-selective COX inhibitor, attenuated mechanical allodynia after placing one loose ligature around the nervus ischiadicus, an adaptation of Bennett and Xie's model in rodents. NP was induced in male Wistar rats by subjecting them to chronic constriction injury (CCI) of the nervus ischiadicus, placing one loose ligature around the peripheral nerve, and a sham surgery (without CCI) was used as control. Indomethacin (2 mg/kg) or vehicle was intraperitoneally and acutely administered in each group of rats and at different time windows (1, 2, 4, 7, 14, 21, and 28 days) after the CCI or sham surgical procedures, followed by von Frey's test for 30 min. The data showed that indomethacin decreased the mechanical allodynia threshold of rats on the first, second, and fourth days after CCI (P<0.05). These findings suggested that inflammatory mechanisms are involved in the induction of NP and that COX-1 and COX-2 are involved in the induction but not in the maintenance of NP.

Allodynia

Peripheral nerve injury

Neurochemical

Nerve Injury

Ligature

10.1590/1414-431x20209255

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Citations (9)

Infralimbic medial prefrontal cortex alters electroacupuncture effect in animals with neuropathic chronic pain

Behavioural Brain Research (2022)

Laís Ferreira Laura Pereira Generoso Ana Carolina Medeiros Priscila Medeiros Renato Leonardo de Freitas

Neurostimulation