L Gradowska

Medical University of Warsaw

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Lao M

Guangdong Medical College

Leszek Pączek

Institute of Biochemistry and Biophysics, Polish Academy of Sciences

D Rowińska

Medical University of Warsaw

Tadeusz Orłowski

Foundation for Polish Science

W Rowińskí

Medical University of Warsaw

Magdalena Durlik

Medical University of Warsaw

I Bartłomiejczyk

Medical University of Warsaw

J Juskowa

Medical University of Warsaw

Z Rancewicz

Medical University of Warsaw

J Wyzgał

Medical University of Warsaw

Cooperative Institutions

Medical University of Warsaw

Wojskowy Instytut Medyczny

Jagiellonian University

Medical University of Silesia

Postgraduate School of Molecular Medicine

Polish Academy of Sciences

SGH Warsaw School of Economics

Central Clinical Hospital

Children's Memorial Health Institute

Institute of Cardiology

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The control of phosphate excretion in uremia.

Journal of Clinical Investigation (1966)

Eduardo Slatopolsky L Gradowska Channivant Kashemsant Raymond M. Keltner Charisma Manley

Uremia

10.1172/jci105382

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Citations (109)

[Treatment of diabetes mellitus in patients after renal transplantation].

PubMed (2002)

J Wyzgał Leszek Pączek G Senatorski Tomasz Pilecki L Gradowska

Diabetes mellitus (DM) is the most common metabolic disease, an independent risk factor of coronary disease, and shortens lifetime in all populations of patients, including kidney transplant recipients. Patients after kidney transplantation are exceptionally predisposed to develop or to exacerbate the preexisting DM. Age, DM in family, CMV infections, genetic factor (HLA A26 and B27), immunosuppressive treatment with steroids or calcineurin inhibitors belong to the major risk factors of diabetes. We analyzed 1300 renal transplant recipients in our center. Out of them 153 suffered from DM. DM de novo revealed 80 pts. Mean age in type I pts was 44.88 years and in type II pts was 57.27 years. De novo diabetics were 56.41 years old in average. CMV infection, potentially pathogenic in development of DM de novo, coexisted in 7.5% of these cases as frequently as in whole TPN population. Most frequently detected HLA antigens were: A2, B8 and DR5. Use of cyclosporine and tacrolimus promoted incidence of DM. We conclude, that low percentage of de novo DM in patients after renal transplantation may result from flexibility in administration of immunosuppressive regimens. Cyclosporine and tacrolimus treatment was switched to sirolimus or mycophenolate mofetil when the glucose intolerance was detected to prevent development of DM.

Sirolimus

Immunosuppression

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Citations (1)

[Secondary retinal detachment in patients with chronic uremia].

PubMed (1983)

E Dróbecka-Brydakowa A Moszczyńska-Kowalska B Dyszyńska-Rościszewska D Rowińska L Gradowska

Uremia

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Intraglomerular protein accumulation in chronically rejected human kidney allografts.

PubMed (1996)

Leszek Pączek I Bartłomiejczyk L Gradowska Rowiński J Szmidt

Kidney Glomerulus

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Living donor renal transplantations in Poland.

PubMed (1996)

Lao M W Rowińskí J Szmidt J Wałaszewski S Frunze

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Cytomegalovirus antibodies in renal transplant recipients.

PubMed (1982)

Mateusz Jankowski Gut W E Nawrocka L Gradowska Z Roncewicz

The relationship between CMV infections and the development of various viral antibodies were studied in successively taken sera from 5 renal kidney recipients. In all of the cases tested the infections were connected with the development of antibodies to immediately early antigens and then specific IgM and antibodies to various CMV early antigens. The increase of antibodies measured by ELISA, CF and immunofluorescence for late CMV antigens were observed in samples taken from two patients. Based on serological findings the relation between CMV infections and quantity of blood received before transplantation was established.

Cytomegalovirus

Immunofluorescence

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Impairment of proteolytic activity in isolated glomeruli and tubules in experimental diabetic nephropathy.

PubMed (1996)

Leszek Pączek J. Soin I Bartłomiejczyk R Królak Lao M

Proteolysis

Proteolytic enzymes

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