Rhianna Bronson

University of Pittsburgh

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Deborah McMahon

University of Pittsburgh

Keira A. Cohen

Johns Hopkins University

Abigail L. Manson

Broad Institute

Arlene Bullotta

University of Pittsburgh

Robbie B. Mailliard

University of Pittsburgh

Jeffrey M. Bethony

George Washington University

Madhu Prabhakaran

National Institute of Allergy and Infectious Diseases

R M Ruprecht

Dana-Farber Cancer Institute

Lara Hoeweler

George Washington University

Ronald J. Bosch

Harvard University

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Harvard University

Johns Hopkins University

National Institute of Allergy and Infectious Diseases

National Institutes of Health

George Washington University

University of Pittsburgh

International AIDS Vaccine Initiative

University of Pittsburgh Medical Center

Johns Hopkins Medicine

Washington University Medical Center

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Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy

The Journal of Immunology (2024)

Renee R. Anderko Allison E. DePuyt Rhianna Bronson Arlene Bullotta Evgenia Aga

Abstract HIV-1 infection greatly alters the NK cell phenotypic and functional repertoire. This is highlighted by the expansion of a rare population of FcRγ– NK cells exhibiting characteristics of traditional immunologic memory in people with HIV (PWH). Although current antiretroviral therapy (ART) effectively controls HIV-1 viremia and disease progression, its impact on HIV-1–associated NK cell abnormalities remains unclear. To address this, we performed a longitudinal analysis detailing conventional and memory-like NK cell characteristics in n = 60 PWH during the first 4 y of ART. Throughout this regimen, a skewed repertoire of cytokine unresponsive FcRγ– memory-like NK cells persisted and accompanied an overall increase in NK surface expression of CD57 and KLRG1, suggestive of progression toward immune senescence. These traits were linked to elevated serum inflammatory biomarkers and increasing Ab titers to human CMV, with human CMV viremia detected in approximately one-third of PWH at years 1–4 of ART. Interestingly, 40% of PWH displayed atypical NK cell subsets, representing intermediate stages of NK-poiesis based on single-cell multiomic trajectory analysis. Our findings indicate that NK cell irregularities persist in PWH despite long-term ART, underscoring the need to better understand the causative mechanisms that prevent full restoration of immune health in PWH.

Viremia

10.4049/jimmunol.2300672

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Erratum: Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

Nature Medicine (1999)

Timothy W. Baba Vladimír Liška Anis H. Khimani Nancy B. Ray P.J. Dailey

Simian immunodeficiency virus

Simian

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10.1038/8859

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Whole Genome Analysis of Mycobacterium Abscessus Reveals Insights into Global Phylogeography and the Evolution of Drug Resistance

Keira A. Cohen Rhianna Bronson Abigail L. Manson Chhavi Gupta Asli Bahadirli-Talbott

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4490

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Ultrasound-guided lymph node fine-needle aspiration for evaluating post-vaccination germinal center responses in humans

STAR Protocols (2023)

Larissa Scholte David J. Leggat Kristen W. Cohen Lara Hoeweler Guacyara C Erwin

The lymph node (LN) is a critical biological site for immune maturation after vaccination as it includes several cell populations critical for priming the antibody response. Here, we present a protocol for sampling the LN and isolating cell populations to evaluate immunogens targeting germline cells. We describe steps for media and tube preparation and sample collection using an ultrasound-guided LN fine-needle aspiration procedure. This protocol is safe, quick, low-cost, and less invasive than excisional biopsy. For complete details on the use and execution of this protocol, please refer to Leggat et al. (2022).1

10.1016/j.xpro.2023.102576

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Citations (1)