Jianhui Zhen

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Gang Liang

Beijing Academy of Agricultural and Forestry Sciences

Ligang Pan

Beijing Academy of Agricultural and Forestry Sciences

Wenwen Gong

Beijing Academy of Agricultural and Forestry Sciences

Wenshen Jia

Beijing Academy of Agricultural and Forestry Sciences

Pengyuan Sun

Beijing Academy of Agricultural and Forestry Sciences

Bingru Li

Sun Yat-sen University

Ruichun Chen

Hebei Food Inspection and Research Institute

Yufei Gao

Dalian University of Technology

Zhaohai Zeng

Xihua University

Zhiyong Zhang

Beijing University of Agriculture

Cooperative Institutions

Beijing Academy of Agricultural and Forestry Sciences

Beijing Research Center for Agricultural and Standards and Testing

Beijing Municipal Ecological and Environmental Monitoring Center

Ministry of Agriculture and Rural Affairs

Texas A&M University

Beijing Normal University

Beijing University of Agriculture

Entry Exit Inspection and Quarantine Bureau

Hebei Food Inspection and Research Institute

Shanghai Jiao Tong University

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Aptamer Sensors for the Detection of Antibiotic Residues— A Mini-Review

Toxics (2023)

Gang Liang Le Song Yufei Gao Kailong Wu Rui Guo

Food security is a global issue, since it is closely related to human health. Antibiotics play a significant role in animal husbandry owing to their desirable broad-spectrum antibacterial activity. However, irrational use of antibiotics has caused serious environmental pollution and food safety problems; thus, the on-site detection of antibiotics is in high demand in environmental analysis and food safety assessment. Aptamer-based sensors are simple to use, accurate, inexpensive, selective, and are suitable for detecting antibiotics for environmental and food safety analysis. This review summarizes the recent advances in aptamer-based electrochemical, fluorescent, and colorimetric sensors for antibiotics detection. The review focuses on the detection principles of different aptamer sensors and recent achievements in developing electrochemical, fluorescent, and colorimetric aptamer sensors. The advantages and disadvantages of different sensors, current challenges, and future trends of aptamer-based sensors are also discussed.

Aptamer

10.3390/toxics11060513

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Citations (13)

pH-controlled UV−Vis sensing strategy for indirect, rapid detection of paraoxon based on molecular form conversion

Sensors and Actuators B Chemical (2021)

Bingru Li Pengyuan Sun Jianhui Zhen Wenwen Gong Zhiyong Zhang

Paraoxon

Linear range

10.1016/j.snb.2021.130715

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Citations (11)

An enzyme-free, ultrasensitive strategy for simultaneous screening of the p-nitrophenyl substituent organophosphorus pesticides

Food Chemistry (2022)

Pengyuan Sun Bingru Li Jianhui Zhen Zhaohai Zeng Wenshen Jia

Paraoxon

Parathion

Parathion methyl

Hydrolase

10.1016/j.foodchem.2022.135218

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Citations (5)

Development of the screen-printed electrodes: A mini review on the application for pesticide detection

Environmental Technology & Innovation (2022)

Gang Liang Zhaoying He Jianhui Zhen Hao Tian Lianfeng Ai

The periodically excessive use of pesticides in agricultural production has caused eco-toxicity and environmental pollution issues. Developing analytical methods for pesticides that respond to the growing need to perform rapid, in situ analysis showed the bio-sensing technique as a complementary tool of classical chromatographic methods for in situ measurements and screening. Compared with the traditional solid-state electrode, the screen-printed electrode (SPE) owns the merits of low cost, easier integration, versatility, portability, smaller sizes and mass-produce, and it has been widely applied for pesticides detection. Herein, the first section of this review briefly introduces the definition of the screen-printing technique (SPT) and the preparation procedure, printing materials and advantages of the SPE, discusses the most important physical and chemical methods for SPE activation. It then summarizes the current utilization of SPE, focus on various available bioreceptors and nanomaterials modified SPE sensors and biosensors, as a novel approach for detection of the pesticides (including organophosphorus pesticides (OPs), carbamate pesticides (CPs), and herbicide pesticides (HPs)). Furthermore, it also covers the sensing principles of the SPE-based sensors along with their analytical performance, advantages and shortcomings. Finally, the current challenges and future directions for the SPE and the SPE-based electrochemical sensors for pollutants are outlined.

Software portability

10.1016/j.eti.2022.102922

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Citations (39)

Label-free hairpin-like aptamer and EIS-based practical, biostable sensor for acetamiprid detection

PLoS ONE (2020)

Jianhui Zhen Gang Liang Ruichun Chen Wenshen Jia

Acetamiprid (ACE) is a kind of broad-spectrum pesticide that has potential health risk to human beings. Aptamers (Ap-DNA (1)) have a great potential as analytical tools for pesticide detection. In this work, a label-free electrochemical sensing assay for ACE determination is presented by electrochemical impedance spectroscopy (EIS). And the specific binding model between ACE and Ap-DNA (1) was further investigated for the first time. Circular dichroism (CD) spectroscopy and EIS demonstrated that the single strand AP-DNA (1) first formed a loosely secondary structure in Tris-HClO 4 (20 mM, pH = 7.4), and then transformed into a more stable hairpin-like structure when incubated in binding buffer (B-buffer). The formed stem-loop bulge provides the specific capturing sites for ACE, forming ACE/AP-DNA (1) complex, and induced the R CT (charge transfer resistance) increase between the solution-based redox probe [Fe(CN) 6 ] 3−/4− and the electrode surface. The change of Δ R CT (charge transfer resistance change, Δ R CT = R CT(after) - R CT(before) ) is positively related to the ACE level. As a result, the AP-DNA (1) biosensor showed a high sensitivity with the ACE concentration range spanning from 5 nM to 200 mM and a detection limit of 1 nM. The impedimetric AP-DNA (1) sensor also showed good selectivity to ACE over other selected pesticides and exhbited excellent performance in environmental water and orange juice samples analysis, with spiked recoveries in the range of 85.8% to 93.4% in lake water and 83.7% to 89.4% in orange juice. With good performance characteristics of practicality, sensitivity and selectivity, the AP-DNA (1) sensor holds a promising application for the on-site ACE detection.

Aptamer

10.1371/journal.pone.0244297

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Citations (21)

Application and evaluation of molecular docking for aptamer and small molecular interaction - A case study with tetracycline antibiotics

Talanta (2023)

Gang Liang Zhaohai Zeng Yufei Gao Tao Xie Jianhui Zhen

Aptamer

Docking (animal)

Molecular Recognition

10.1016/j.talanta.2023.124942

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Citations (15)