The pathogenesis of abdominal symptoms in premature infants with hypothyroxinemia is not understood; therefore, we investigated changes in gut hormones before and after levothyroxine sodium (T4-Na) supplementation in preterm infants with abdominal symptoms and hypothyroxinemia.In eight preterm study subjects and 14 gestational age-matched controls, fasting serum concentration of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin and ghrelin was measured using a bead array system.Serum GLP-1, GIP and PYY in the subjects before T4-Na supplementation were lower than in controls at age 2 weeks. After improvement of abdominal symptoms and free thyroxine, serum levels of the three gut hormones in the subjects were increased and were not different from those in the control patients.In preterm infants with abdominal symptoms, serum GLP-1, GIP and PYY might be related to thyroid function.
Aim: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated.
We evaluated the neurologic outcomes of 107 infants with birth weights of less than 1,000g who had been admitted to our hospital from October 1981 to March 1986. Their outcomes were confirmed during a follow-up period of 20-39 years (mean: 75 years). The diagnoses were normal in 71, cerebral palsy in 13, mental retardation in 11, borderline intelligence in 11, and spinal palsy due to birth injury in 1. Only 3 infants with cerebral palsy had developed epilepsy. Among the infants with birth weights of less than 1,000g hospitalized in this tertiary care center, about one-third still had some major or minor neurologic abnormalities.
Abstract We studied the cytokine profile of two siblings with neonatal lupus erythematosus (NLE) born to a mother positive for serum anti‐Ro and ‐La antibodies, who did not receive any medication during the two pregnancies. The first sibling was found to have complete atrioventricular block in utero and became severely ill after birth. He fulfilled the diagnostic criteria for hemophagocytic lymphohistiocytosis on day 2. The second sibling did not have any fetal symptoms. He was generally stable after birth, but with typical skin rash. Laboratory data suggested that they both had hypercytokinemia during the neonatal period, requiring corticosteroid treatment. Interleukin (IL)‐6, interferon‐γ, IL‐8 and monocyte chemotactic protein‐1 were elevated in both cases, while IL‐12, IL‐13 and IL‐17 were elevated only in the second sibling. Comparison of the cytokine profiles suggests the potential roles of different cytokines in the onset and clinical manifestations of NLE.
